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Protein

Tyrosine-protein kinase

Gene

Abl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:Abl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87859 Abl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiQ3SYK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026842
ExpressionAtlasiQ3SYK5 baseline and differential
GenevisibleiQ3SYK5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3SYK5 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ3SYK5
SMRiQ3SYK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 140SH3InterPro annotationAdd BLAST61
Domaini146 – 236SH2InterPro annotationAdd BLAST91
Domaini261 – 512Protein kinaseInterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
HOGENOMiHOG000231988
HOVERGENiHBG004162
OMAiGAFRESG
OrthoDBiEOG091G0D46
PhylomeDBiQ3SYK5

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.101 hit
InterProiView protein in InterPro
IPR033221 ABL1
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF88 PTHR24418:SF88, 1 hit
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SYK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR
60 70 80 90 100
PVASDFEPQG LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS
110 120 130 140 150
ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV PSNYITPVNS LEKHSWYHGP
160 170 180 190 200
VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV YHYRINTASD
210 220 230 240 250
GKLYVSSESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN KPTIYGVSPN
260 270 280 290 300
YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE
310 320 330 340 350
EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN
360 370 380 390 400
RQEVSAVVLL YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD
410 420 430 440 450
FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD VWAFGVLLWE
460 470 480 490 500
IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS
510 520 530 540 550
DRPSFAEIHQ AFETMFQESS ISDEVEKELG KRGTRGGAGS MLQAPELPTK
560 570 580 590 600
TRTCRRAAEQ KDAPDTPELL HTKGLGESDA LDSEPAVSPL LPRKERGPPD
610 620 630 640 650
GSLNEDERLL PRDRKTNLFS ALIKKKKKMA PTPPKRSSSF REMDGQPDRR
660 670 680 690 700
GASEDDSREL CNGPPALTSD AAEPTKSPKA SNGAGVPNGA FREPGNSGFR
710 720 730 740 750
SPHMWKKSST LTGSRLAAAE EESGMSSSKR FLRSCSASCM PHGARDTEWR
760 770 780 790 800
SVTLPRDLPS AGKQFDSSTF GGHKSEKPAL PRKRTSESRS EQVAKSTAMP
810 820 830 840 850
PPRLVKKNEE AAEEGFKDTE SSPGSSPPSL TPKLLRRQVT ASPSSGLSHK
860 870 880 890 900
EEATKGSASG MGTPATAEPA PPSNKVGLSK ASSEEMRVRR HKHSSESPGR
910 920 930 940 950
DKGRLAKLKP APPPPPACTG KAGKPAQSPS QEAGEAGGPT KTKCTSLAMD
960 970 980 990 1000
AVNTDPTKAG PPGEGLRKPV PPSVPKPQST AKPPGTPTSP VSTPSTAPAP
1010 1020 1030 1040 1050
SPLAGDQQPS SAAFIPLIST RVSLRKTRQP PERIASGTIT KGVVLDSTEA
1060 1070 1080 1090 1100
LCLAISRNSE QMASHSAVLE AGKNLYTFCV SYVDSIQQMR NKFAFREAIN
1110 1120 1130 1140
KLESNLRELQ ICPATASSGP AATQDFSKLL SSVKEISDIV RR
Length:1,142
Mass (Da):124,769
Last modified:October 11, 2005 - v1
Checksum:i7A9DB9E772EAF05F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103770 mRNA Translation: AAI03771.1
RefSeqiNP_001106174.1, NM_001112703.2
UniGeneiMm.1318

Genome annotation databases

GeneIDi11350
UCSCiuc008jeb.3 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3SYK5_MOUSE
AccessioniPrimary (citable) accession number: Q3SYK5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)