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Protein

Tyrosine-protein kinase

Gene

Abl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:Abl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87859. Abl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiQ3SYK5.
PaxDbiQ3SYK5.
PRIDEiQ3SYK5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026842.
ExpressionAtlasiQ3SYK5. baseline and differential.
GenevisibleiQ3SYK5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3SYK5. 1 interaction.
STRINGi10090.ENSMUSP00000075167.

Structurei

3D structure databases

ProteinModelPortaliQ3SYK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 14061SH3InterPro annotationAdd
BLAST
Domaini146 – 23691SH2InterPro annotationAdd
BLAST
Domaini261 – 512252Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231988.
HOVERGENiHBG004162.
OMAiGAFRESG.
OrthoDBiEOG091G0D46.
PhylomeDBiQ3SYK5.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR033221. ABL1.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF88. PTHR24418:SF88. 1 hit.
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SYK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR
60 70 80 90 100
PVASDFEPQG LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS
110 120 130 140 150
ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV PSNYITPVNS LEKHSWYHGP
160 170 180 190 200
VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV YHYRINTASD
210 220 230 240 250
GKLYVSSESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN KPTIYGVSPN
260 270 280 290 300
YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE
310 320 330 340 350
EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN
360 370 380 390 400
RQEVSAVVLL YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD
410 420 430 440 450
FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD VWAFGVLLWE
460 470 480 490 500
IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS
510 520 530 540 550
DRPSFAEIHQ AFETMFQESS ISDEVEKELG KRGTRGGAGS MLQAPELPTK
560 570 580 590 600
TRTCRRAAEQ KDAPDTPELL HTKGLGESDA LDSEPAVSPL LPRKERGPPD
610 620 630 640 650
GSLNEDERLL PRDRKTNLFS ALIKKKKKMA PTPPKRSSSF REMDGQPDRR
660 670 680 690 700
GASEDDSREL CNGPPALTSD AAEPTKSPKA SNGAGVPNGA FREPGNSGFR
710 720 730 740 750
SPHMWKKSST LTGSRLAAAE EESGMSSSKR FLRSCSASCM PHGARDTEWR
760 770 780 790 800
SVTLPRDLPS AGKQFDSSTF GGHKSEKPAL PRKRTSESRS EQVAKSTAMP
810 820 830 840 850
PPRLVKKNEE AAEEGFKDTE SSPGSSPPSL TPKLLRRQVT ASPSSGLSHK
860 870 880 890 900
EEATKGSASG MGTPATAEPA PPSNKVGLSK ASSEEMRVRR HKHSSESPGR
910 920 930 940 950
DKGRLAKLKP APPPPPACTG KAGKPAQSPS QEAGEAGGPT KTKCTSLAMD
960 970 980 990 1000
AVNTDPTKAG PPGEGLRKPV PPSVPKPQST AKPPGTPTSP VSTPSTAPAP
1010 1020 1030 1040 1050
SPLAGDQQPS SAAFIPLIST RVSLRKTRQP PERIASGTIT KGVVLDSTEA
1060 1070 1080 1090 1100
LCLAISRNSE QMASHSAVLE AGKNLYTFCV SYVDSIQQMR NKFAFREAIN
1110 1120 1130 1140
KLESNLRELQ ICPATASSGP AATQDFSKLL SSVKEISDIV RR
Length:1,142
Mass (Da):124,769
Last modified:October 11, 2005 - v1
Checksum:i7A9DB9E772EAF05F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103770 mRNA. Translation: AAI03771.1.
RefSeqiNP_001106174.1. NM_001112703.2.
UniGeneiMm.1318.

Genome annotation databases

GeneIDi11350.
UCSCiuc008jeb.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103770 mRNA. Translation: AAI03771.1.
RefSeqiNP_001106174.1. NM_001112703.2.
UniGeneiMm.1318.

3D structure databases

ProteinModelPortaliQ3SYK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3SYK5. 1 interaction.
STRINGi10090.ENSMUSP00000075167.

Proteomic databases

MaxQBiQ3SYK5.
PaxDbiQ3SYK5.
PRIDEiQ3SYK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11350.
UCSCiuc008jeb.3. mouse.

Organism-specific databases

CTDi25.
MGIiMGI:87859. Abl1.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231988.
HOVERGENiHBG004162.
OMAiGAFRESG.
OrthoDBiEOG091G0D46.
PhylomeDBiQ3SYK5.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026842.
ExpressionAtlasiQ3SYK5. baseline and differential.
GenevisibleiQ3SYK5. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR033221. ABL1.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF88. PTHR24418:SF88. 1 hit.
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3SYK5_MOUSE
AccessioniPrimary (citable) accession number: Q3SYK5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.