Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin-associated protein 19-7

Gene

KRTAP19-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-7
Gene namesi
Name:KRTAP19-7
Synonyms:KAP19.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18942. KRTAP19-7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868084.

Polymorphism and mutation databases

BioMutaiKRTAP19-7.
DMDMi88909173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239091 – 63Keratin-associated protein 19-7Add BLAST63

Proteomic databases

PaxDbiQ3SYF9.
PeptideAtlasiQ3SYF9.
PRIDEiQ3SYF9.

PTM databases

iPTMnetiQ3SYF9.
PhosphoSitePlusiQ3SYF9.

Expressioni

Gene expression databases

BgeeiENSG00000244362.
CleanExiHS_KRTAP19-7.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130657. 5 interactors.
IntActiQ3SYF9. 13 interactors.
STRINGi9606.ENSP00000334696.

Structurei

3D structure databases

ProteinModelPortaliQ3SYF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KC9C. Eukaryota.
ENOG4110P76. LUCA.
GeneTreeiENSGT00730000112756.
InParanoidiQ3SYF9.

Family and domain databases

InterProiView protein in InterPro
IPR021743. KRTAP_type6/8/16/19/20/21.
PfamiView protein in Pfam
PF11759. KRTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SYF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSGSYYGG LGYGCGGFGG LGYGYSCGCG SFRRLGYGCG YGGYRYSCCH
60
PSCYGGYWSS GFY
Length:63
Mass (Da):6,644
Last modified:October 11, 2005 - v1
Checksum:iAC24810FC35B6F09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096949 mRNA. Translation: BAE46364.1.
BC103836 mRNA. Translation: AAI03837.1.
BC103837 mRNA. Translation: AAI03838.1.
BC103838 mRNA. Translation: AAI03839.1.
CCDSiCCDS13599.1.
RefSeqiNP_853645.1. NM_181614.1.
UniGeneiHs.553696.

Genome annotation databases

EnsembliENST00000334849; ENSP00000334696; ENSG00000244362.
GeneIDi337974.
KEGGihsa:337974.
UCSCiuc011adb.3. human.

Similar proteinsi

Entry informationi

Entry nameiKR197_HUMAN
AccessioniPrimary (citable) accession number: Q3SYF9
Secondary accession number(s): Q08EP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families