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Protein

Keratin-associated protein 19-7

Gene

KRTAP19-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-7
Gene namesi
Name:KRTAP19-7
Synonyms:KAP19.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000244362.2
HGNCiHGNC:18942 KRTAP19-7
neXtProtiNX_Q3SYF9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868084

Polymorphism and mutation databases

BioMutaiKRTAP19-7
DMDMi88909173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239091 – 63Keratin-associated protein 19-7Add BLAST63

Proteomic databases

PaxDbiQ3SYF9
PeptideAtlasiQ3SYF9
PRIDEiQ3SYF9

PTM databases

iPTMnetiQ3SYF9
PhosphoSitePlusiQ3SYF9

Expressioni

Gene expression databases

BgeeiENSG00000244362
CleanExiHS_KRTAP19-7

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130657, 5 interactors
IntActiQ3SYF9, 13 interactors
STRINGi9606.ENSP00000334696

Structurei

3D structure databases

ProteinModelPortaliQ3SYF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KC9C Eukaryota
ENOG4110P76 LUCA
GeneTreeiENSGT00910000145934
InParanoidiQ3SYF9

Family and domain databases

InterProiView protein in InterPro
IPR021743 KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759 KRTAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SYF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSGSYYGG LGYGCGGFGG LGYGYSCGCG SFRRLGYGCG YGGYRYSCCH
60
PSCYGGYWSS GFY
Length:63
Mass (Da):6,644
Last modified:October 11, 2005 - v1
Checksum:iAC24810FC35B6F09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096949 mRNA Translation: BAE46364.1
BC103836 mRNA Translation: AAI03837.1
BC103837 mRNA Translation: AAI03838.1
BC103838 mRNA Translation: AAI03839.1
CCDSiCCDS13599.1
RefSeqiNP_853645.1, NM_181614.1
UniGeneiHs.553696

Genome annotation databases

EnsembliENST00000334849; ENSP00000334696; ENSG00000244362
GeneIDi337974
KEGGihsa:337974
UCSCiuc011adb.3 human

Similar proteinsi

Entry informationi

Entry nameiKR197_HUMAN
AccessioniPrimary (citable) accession number: Q3SYF9
Secondary accession number(s): Q08EP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 11, 2005
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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