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Protein

Keratin-associated protein 19-7

Gene

KRTAP19-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-7
Gene namesi
Name:KRTAP19-7
Synonyms:KAP19.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18942. KRTAP19-7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868084.

Polymorphism and mutation databases

BioMutaiKRTAP19-7.
DMDMi88909173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6363Keratin-associated protein 19-7PRO_0000223909Add
BLAST

Proteomic databases

PaxDbiQ3SYF9.
PRIDEiQ3SYF9.

PTM databases

iPTMnetiQ3SYF9.

Expressioni

Gene expression databases

CleanExiHS_KRTAP19-7.
ExpressionAtlasiQ3SYF9. differential.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAMK2BQ135543EBI-10241353,EBI-1058722
DAB1O755533EBI-10241353,EBI-7875264
RBPMSQ930623EBI-10241353,EBI-740322
RHOXF2Q9BQY43EBI-10241353,EBI-372094
VAC14Q08AM63EBI-10241353,EBI-2107455

Protein-protein interaction databases

BioGridi130657. 5 interactions.
IntActiQ3SYF9. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3SYF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KC9C. Eukaryota.
ENOG4110P76. LUCA.
GeneTreeiENSGT00730000112756.
InParanoidiQ3SYF9.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SYF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSGSYYGG LGYGCGGFGG LGYGYSCGCG SFRRLGYGCG YGGYRYSCCH
60
PSCYGGYWSS GFY
Length:63
Mass (Da):6,644
Last modified:October 11, 2005 - v1
Checksum:iAC24810FC35B6F09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096949 mRNA. Translation: BAE46364.1.
BC103836 mRNA. Translation: AAI03837.1.
BC103837 mRNA. Translation: AAI03838.1.
BC103838 mRNA. Translation: AAI03839.1.
CCDSiCCDS13599.1.
RefSeqiNP_853645.1. NM_181614.1.
UniGeneiHs.553696.

Genome annotation databases

EnsembliENST00000334849; ENSP00000334696; ENSG00000244362.
GeneIDi337974.
KEGGihsa:337974.
UCSCiuc011adb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096949 mRNA. Translation: BAE46364.1.
BC103836 mRNA. Translation: AAI03837.1.
BC103837 mRNA. Translation: AAI03838.1.
BC103838 mRNA. Translation: AAI03839.1.
CCDSiCCDS13599.1.
RefSeqiNP_853645.1. NM_181614.1.
UniGeneiHs.553696.

3D structure databases

ProteinModelPortaliQ3SYF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130657. 5 interactions.
IntActiQ3SYF9. 5 interactions.

PTM databases

iPTMnetiQ3SYF9.

Polymorphism and mutation databases

BioMutaiKRTAP19-7.
DMDMi88909173.

Proteomic databases

PaxDbiQ3SYF9.
PRIDEiQ3SYF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334849; ENSP00000334696; ENSG00000244362.
GeneIDi337974.
KEGGihsa:337974.
UCSCiuc011adb.3. human.

Organism-specific databases

CTDi337974.
GeneCardsiKRTAP19-7.
HGNCiHGNC:18942. KRTAP19-7.
neXtProtiNX_Q3SYF9.
PharmGKBiPA134868084.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC9C. Eukaryota.
ENOG4110P76. LUCA.
GeneTreeiENSGT00730000112756.
InParanoidiQ3SYF9.

Miscellaneous databases

GenomeRNAii337974.
PROiQ3SYF9.

Gene expression databases

CleanExiHS_KRTAP19-7.
ExpressionAtlasiQ3SYF9. differential.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair root.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKR197_HUMAN
AccessioniPrimary (citable) accession number: Q3SYF9
Secondary accession number(s): Q08EP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.