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Q3SYC2

- MOGT2_HUMAN

UniProt

Q3SYC2 - MOGT2_HUMAN

Protein

2-acylglycerol O-acyltransferase 2

Gene

MOGAT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.1 Publication

    Catalytic activityi

    Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.

    Enzyme regulationi

    Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.By similarity

    Kineticsi

    1. KM=45 µM for sn-1-monooleoylglycerol1 Publication

    Pathwayi

    GO - Molecular functioni

    1. 2-acylglycerol O-acyltransferase activity Source: UniProtKB-EC
    2. acetyltransferase activity Source: Ensembl

    GO - Biological processi

    1. diacylglycerol biosynthetic process Source: Ensembl
    2. glycerol metabolic process Source: UniProtKB-KW
    3. intestinal absorption Source: Ensembl
    4. triglyceride biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00282.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-acylglycerol O-acyltransferase 2 (EC:2.3.1.22)
    Alternative name(s):
    Acyl-CoA:monoacylglycerol acyltransferase 2
    Short name:
    MGAT2
    Short name:
    hMGAT2
    Diacylglycerol O-acyltransferase candidate 5
    Short name:
    hDC5
    Diacylglycerol acyltransferase 2-like protein 5
    Monoacylglycerol O-acyltransferase 2
    Gene namesi
    Name:MOGAT2
    Synonyms:DC5, DGAT2L5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23248. MOGAT2.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134936582.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3343342-acylglycerol O-acyltransferase 2PRO_0000249062Add
    BLAST

    Proteomic databases

    PaxDbiQ3SYC2.
    PRIDEiQ3SYC2.

    Expressioni

    Tissue specificityi

    Highly expressed in liver, small intestine, colon, stomach and kidney.2 Publications

    Gene expression databases

    BgeeiQ3SYC2.
    CleanExiHS_MOGAT2.
    GenevestigatoriQ3SYC2.

    Organism-specific databases

    HPAiHPA028834.

    Interactioni

    Protein-protein interaction databases

    BioGridi123154. 3 interactions.
    STRINGi9606.ENSP00000198801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SYC2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 3715HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG258143.
    HOGENOMiHOG000179738.
    HOVERGENiHBG065791.
    InParanoidiQ3SYC2.
    KOiK14457.
    OMAiCKLFEEH.
    OrthoDBiEOG7KH9KB.
    PhylomeDBiQ3SYC2.
    TreeFamiTF314707.

    Family and domain databases

    InterProiIPR007130. DAGAT.
    [Graphical view]
    PANTHERiPTHR12317. PTHR12317. 1 hit.
    PfamiPF03982. DAGAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3SYC2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVEFAPLFMP WERRLQTLAV LQFVFSFLAL AEICTVGFIA LLFTRFWLLT    50
    VLYAAWWYLD RDKPRQGGRH IQAIRCWTIW KYMKDYFPIS LVKTAELDPS 100
    RNYIAGFHPH GVLAVGAFAN LCTESTGFSS IFPGIRPHLM MLTLWFRAPF 150
    FRDYIMSAGL VTSEKESAAH ILNRKGGGNL LGIIVGGAQE ALDARPGSFT 200
    LLLRNRKGFV RLALTHGAPL VPIFSFGEND LFDQIPNSSG SWLRYIQNRL 250
    QKIMGISLPL FHGRGVFQYS FGLIPYRRPI TTVVGKPIEV QKTLHPSEEE 300
    VNQLHQRYIK ELCNLFEAHK LKFNIPADQH LEFC 334
    Length:334
    Mass (Da):38,196
    Last modified:September 5, 2006 - v2
    Checksum:i57C4A964BAFA76BD
    GO
    Isoform 2 (identifier: Q3SYC2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:252
    Mass (Da):28,283
    Checksum:i902B6B67B2E8CC02
    GO
    Isoform 3 (identifier: Q3SYC2-3) [UniParc]FASTAAdd to Basket

    Also known as: MGAT2V, Trunc

    The sequence of this isoform differs from the canonical sequence as follows:
         218-284: APLVPIFSFG...PYRRPITTVV → YQASGKSTLG...PQRRLSDLRN
         285-334: Missing.

    Show »
    Length:284
    Mass (Da):32,298
    Checksum:iE56F74332AF8D2DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421L → P in BAB15436. (PubMed:14702039)Curated
    Sequence conflicti267 – 2671F → L in BAC87534. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91M → V.1 Publication
    Corresponds to variant rs554202 [ dbSNP | Ensembl ].
    VAR_027390
    Natural varianti196 – 1961P → H.
    Corresponds to variant rs34582952 [ dbSNP | Ensembl ].
    VAR_048857
    Natural varianti313 – 3131C → Y.
    Corresponds to variant rs12281468 [ dbSNP | Ensembl ].
    VAR_027391

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform 2. 1 PublicationVSP_020358Add
    BLAST
    Alternative sequencei218 – 28467APLVP…ITTVV → YQASGKSTLGSVGNWQGFYF GGKMAETNADSILVEIFSPF TIKIIFWCLMPKYLEKFPQR RLSDLRN in isoform 3. 1 PublicationVSP_020359Add
    BLAST
    Alternative sequencei285 – 33450Missing in isoform 3. 1 PublicationVSP_020360Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157608 mRNA. Translation: AAO23672.1.
    AK026297 mRNA. Translation: BAB15436.1.
    AK128620 mRNA. Translation: BAC87534.1.
    AK291998 mRNA. Translation: BAF84687.1.
    CH471076 Genomic DNA. Translation: EAW74983.1.
    BC103876 mRNA. Translation: AAI03877.1.
    BC103877 mRNA. Translation: AAI03878.1.
    BC103878 mRNA. Translation: AAI03879.1.
    CCDSiCCDS8240.1. [Q3SYC2-1]
    RefSeqiNP_079374.2. NM_025098.2. [Q3SYC2-1]
    UniGeneiHs.288568.

    Genome annotation databases

    EnsembliENST00000198801; ENSP00000198801; ENSG00000166391. [Q3SYC2-1]
    ENST00000525093; ENSP00000436537; ENSG00000166391. [Q3SYC2-3]
    ENST00000526712; ENSP00000436283; ENSG00000166391. [Q3SYC2-2]
    GeneIDi80168.
    KEGGihsa:80168.
    UCSCiuc001oww.1. human. [Q3SYC2-3]
    uc010rru.2. human. [Q3SYC2-1]

    Polymorphism databases

    DMDMi114150036.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157608 mRNA. Translation: AAO23672.1 .
    AK026297 mRNA. Translation: BAB15436.1 .
    AK128620 mRNA. Translation: BAC87534.1 .
    AK291998 mRNA. Translation: BAF84687.1 .
    CH471076 Genomic DNA. Translation: EAW74983.1 .
    BC103876 mRNA. Translation: AAI03877.1 .
    BC103877 mRNA. Translation: AAI03878.1 .
    BC103878 mRNA. Translation: AAI03879.1 .
    CCDSi CCDS8240.1. [Q3SYC2-1 ]
    RefSeqi NP_079374.2. NM_025098.2. [Q3SYC2-1 ]
    UniGenei Hs.288568.

    3D structure databases

    ProteinModelPortali Q3SYC2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123154. 3 interactions.
    STRINGi 9606.ENSP00000198801.

    Chemistry

    ChEMBLi CHEMBL2439944.

    Polymorphism databases

    DMDMi 114150036.

    Proteomic databases

    PaxDbi Q3SYC2.
    PRIDEi Q3SYC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000198801 ; ENSP00000198801 ; ENSG00000166391 . [Q3SYC2-1 ]
    ENST00000525093 ; ENSP00000436537 ; ENSG00000166391 . [Q3SYC2-3 ]
    ENST00000526712 ; ENSP00000436283 ; ENSG00000166391 . [Q3SYC2-2 ]
    GeneIDi 80168.
    KEGGi hsa:80168.
    UCSCi uc001oww.1. human. [Q3SYC2-3 ]
    uc010rru.2. human. [Q3SYC2-1 ]

    Organism-specific databases

    CTDi 80168.
    GeneCardsi GC11P075428.
    HGNCi HGNC:23248. MOGAT2.
    HPAi HPA028834.
    MIMi 610270. gene.
    neXtProti NX_Q3SYC2.
    PharmGKBi PA134936582.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258143.
    HOGENOMi HOG000179738.
    HOVERGENi HBG065791.
    InParanoidi Q3SYC2.
    KOi K14457.
    OMAi CKLFEEH.
    OrthoDBi EOG7KH9KB.
    PhylomeDBi Q3SYC2.
    TreeFami TF314707.

    Enzyme and pathway databases

    UniPathwayi UPA00282 .

    Miscellaneous databases

    GeneWikii MOGAT2.
    GenomeRNAii 80168.
    NextBioi 70479.
    PROi Q3SYC2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3SYC2.
    CleanExi HS_MOGAT2.
    Genevestigatori Q3SYC2.

    Family and domain databases

    InterProi IPR007130. DAGAT.
    [Graphical view ]
    PANTHERi PTHR12317. PTHR12317. 1 hit.
    Pfami PF03982. DAGAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine."
      Yen C.-L.E., Farese R.V. Jr.
      J. Biol. Chem. 278:18532-18537(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Tissue: Intestine.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Small intestine and Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT VAL-9.
    5. "Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity."
      Lockwood J.F., Cao J., Burn P., Shi Y.
      Am. J. Physiol. 285:E927-E937(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiMOGT2_HUMAN
    AccessioniPrimary (citable) accession number: Q3SYC2
    Secondary accession number(s): A8K7I3
    , Q3SYC1, Q6ZQZ2, Q86UH6, Q9H630
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3