ID   FX4L6_HUMAN             Reviewed;         417 AA.
AC   Q3SYB3; B2RPC4; Q4V336;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   13-OCT-2009, entry version 41.
DE   RecName: Full=Forkhead box protein D4-like 6;
DE            Short=FOXD4-like 6;
GN   Name=FOXD4L6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- MISCELLANEOUS: 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4,
CC       FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of
CC       the 9q12 chromosome region. They are very similar and it is
CC       therefore difficult to provide a clear and unambiguous protein
CC       sequence. Our sequences are in agreement with HGNC nomenclature.
CC   -!- SIMILARITY: Contains 1 fork-head DNA-binding domain.
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DR   EMBL; BX255923; CAI94919.1; -; Genomic_DNA.
DR   EMBL; BC103887; AAI03888.1; -; mRNA.
DR   EMBL; BC137365; AAI37366.1; -; mRNA.
DR   EMBL; BC137366; AAI37367.1; -; mRNA.
DR   IPI; IPI00654829; -.
DR   RefSeq; NP_001078945.1; -.
DR   UniGene; Hs.652377; -.
DR   SMR; Q3SYB3; 108-203.
DR   PRIDE; Q3SYB3; -.
DR   Ensembl; ENST00000377473; ENSP00000366693; ENSG00000204793; Homo sapiens.
DR   Ensembl; ENST00000437343; ENSP00000393152; ENSG00000204793; Homo sapiens.
DR   GeneID; 653404; -.
DR   KEGG; hsa:653404; -.
DR   UCSC; uc004afi.2; human.
DR   CTD; 653404; -.
DR   GeneCards; GC09M068489; -.
DR   HGNC; HGNC:31986; FOXD4L6.
DR   HPA; HPA012836; -.
DR   HOGENOM; Q3SYB3; -.
DR   HOVERGEN; Q3SYB3; -.
DR   NextBio; 123194; -.
DR   CleanEx; HS_FOXD4L6; -.
DR   Genevestigator; Q3SYB3; -.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001766; TF_fork_head.
DR   InterPro; IPR018122; TF_fork_head_CS.
DR   InterPro; IPR011991; Wing_hlx_DNA_bd.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   PANTHER; PTHR11829; Fork_box_protein; 1.
DR   Pfam; PF00250; Fork_head; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   ProDom; PD000425; TF_Fork_head; 1.
DR   SMART; SM00339; FH; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    417       Forkhead box protein D4-like 6.
FT                                /FTId=PRO_0000301979.
FT   DNA_BIND    108    202       Fork-head.
FT   COMPBIAS    211    267       Pro-rich.
FT   CONFLICT    416    416       P -> R (in Ref. 2; CAI94919).
SQ   SEQUENCE   417 AA;  45787 MW;  0A21FCC4EC1D66CE CRC64;
     MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ
     VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
     ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
     YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
     APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
     PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
     ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC
//