ID   FX4L6_HUMAN             Reviewed;         417 AA.
AC   Q3SYB3; B2RPC4; Q4V336;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   27-MAR-2024, entry version 148.
DE   RecName: Full=Forkhead box protein D4-like 6;
DE            Short=FOXD4-like 6;
GN   Name=FOXD4L6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q3SYB3; P02649: APOE; NbExp=3; IntAct=EBI-6425864, EBI-1222467;
CC       Q3SYB3; P78540: ARG2; NbExp=3; IntAct=EBI-6425864, EBI-9056613;
CC       Q3SYB3; P54252: ATXN3; NbExp=3; IntAct=EBI-6425864, EBI-946046;
CC       Q3SYB3; P99999: CYCS; NbExp=3; IntAct=EBI-6425864, EBI-446479;
CC       Q3SYB3; Q9NX09: DDIT4; NbExp=3; IntAct=EBI-6425864, EBI-715104;
CC       Q3SYB3; P26378-2: ELAVL4; NbExp=3; IntAct=EBI-6425864, EBI-21603100;
CC       Q3SYB3; P42858: HTT; NbExp=6; IntAct=EBI-6425864, EBI-466029;
CC       Q3SYB3; P05107: ITGB2; NbExp=3; IntAct=EBI-6425864, EBI-300173;
CC       Q3SYB3; P13473-2: LAMP2; NbExp=3; IntAct=EBI-6425864, EBI-21591415;
CC       Q3SYB3; Q5T3J3: LRIF1; NbExp=3; IntAct=EBI-6425864, EBI-473196;
CC       Q3SYB3; Q99750: MDFI; NbExp=6; IntAct=EBI-6425864, EBI-724076;
CC       Q3SYB3; Q92597: NDRG1; NbExp=3; IntAct=EBI-6425864, EBI-716486;
CC       Q3SYB3; P00747: PLG; NbExp=3; IntAct=EBI-6425864, EBI-999394;
CC       Q3SYB3; P49810: PSEN2; NbExp=3; IntAct=EBI-6425864, EBI-2010251;
CC       Q3SYB3; Q6NZ63: STEAP1B; NbExp=3; IntAct=EBI-6425864, EBI-12952093;
CC       Q3SYB3; P31948: STIP1; NbExp=3; IntAct=EBI-6425864, EBI-1054052;
CC       Q3SYB3; Q92956: TNFRSF14; NbExp=3; IntAct=EBI-6425864, EBI-1056653;
CC       Q3SYB3; Q96BH6; NbExp=3; IntAct=EBI-6425864, EBI-25872486;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX255923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC103887; AAI03888.1; -; mRNA.
DR   EMBL; BC137365; AAI37366.1; -; mRNA.
DR   EMBL; BC137366; AAI37367.1; -; mRNA.
DR   CCDS; CCDS43826.1; -.
DR   RefSeq; NP_001078945.1; NM_001085476.1.
DR   AlphaFoldDB; Q3SYB3; -.
DR   SMR; Q3SYB3; -.
DR   BioGRID; 575756; 50.
DR   IntAct; Q3SYB3; 41.
DR   STRING; 9606.ENSP00000484875; -.
DR   iPTMnet; Q3SYB3; -.
DR   PhosphoSitePlus; Q3SYB3; -.
DR   BioMuta; FOXD4L6; -.
DR   DMDM; 166214939; -.
DR   MassIVE; Q3SYB3; -.
DR   PaxDb; 9606-ENSP00000484875; -.
DR   PeptideAtlas; Q3SYB3; -.
DR   Antibodypedia; 73303; 18 antibodies from 11 providers.
DR   DNASU; 653404; -.
DR   Ensembl; ENST00000622588.2; ENSP00000484875.1; ENSG00000273514.2.
DR   GeneID; 653404; -.
DR   KEGG; hsa:653404; -.
DR   MANE-Select; ENST00000622588.2; ENSP00000484875.1; NM_001085476.4; NP_001078945.1.
DR   UCSC; uc004afi.3; human.
DR   AGR; HGNC:31986; -.
DR   CTD; 653404; -.
DR   GeneCards; FOXD4L6; -.
DR   HGNC; HGNC:31986; FOXD4L6.
DR   HPA; ENSG00000273514; Tissue enhanced (brain).
DR   neXtProt; NX_Q3SYB3; -.
DR   OpenTargets; ENSG00000273514; -.
DR   PharmGKB; PA162388805; -.
DR   VEuPathDB; HostDB:ENSG00000273514; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000163353; -.
DR   HOGENOM; CLU_040357_3_1_1; -.
DR   InParanoid; Q3SYB3; -.
DR   OMA; FKRHHPP; -.
DR   OrthoDB; 5385885at2759; -.
DR   PhylomeDB; Q3SYB3; -.
DR   TreeFam; TF316127; -.
DR   PathwayCommons; Q3SYB3; -.
DR   SignaLink; Q3SYB3; -.
DR   BioGRID-ORCS; 653404; 201 hits in 631 CRISPR screens.
DR   GenomeRNAi; 653404; -.
DR   Pharos; Q3SYB3; Tdark.
DR   PRO; PR:Q3SYB3; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q3SYB3; Protein.
DR   Bgee; ENSG00000273514; Expressed in right uterine tube and 31 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd20048; FH_FOXD4-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR   PANTHER; PTHR11829:SF350; FORKHEAD BOX PROTEIN D4-LIKE 3-RELATED; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..417
FT                   /note="Forkhead box protein D4-like 6"
FT                   /id="PRO_0000301979"
FT   DNA_BIND        108..202
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..47
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  45787 MW;  0A21FCC4EC1D66CE CRC64;
     MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ
     VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
     ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
     YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
     APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
     PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
     ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC
//