ID   FX4L6_HUMAN             Reviewed;         417 AA.
AC   Q3SYB3; B2RPC4; Q4V336;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   14-DEC-2011, entry version 64.
DE   RecName: Full=Forkhead box protein D4-like 6;
DE            Short=FOXD4-like 6;
GN   Name=FOXD4L6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- MISCELLANEOUS: 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4,
CC       FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of
CC       the 9q12 chromosome region. They are very similar and it is
CC       therefore difficult to provide a clear and unambiguous protein
CC       sequence. Our sequences are in agreement with HGNC nomenclature.
CC   -!- SIMILARITY: Contains 1 fork-head DNA-binding domain.
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DR   EMBL; BX255923; CAI94919.1; -; Genomic_DNA.
DR   EMBL; BC103887; AAI03888.1; -; mRNA.
DR   EMBL; BC137365; AAI37366.1; -; mRNA.
DR   EMBL; BC137366; AAI37367.1; -; mRNA.
DR   IPI; IPI00654829; -.
DR   RefSeq; NP_001078945.1; NM_001085476.1.
DR   UniGene; Hs.652377; -.
DR   HSSP; Q01167; 2C6Y.
DR   ProteinModelPortal; Q3SYB3; -.
DR   SMR; Q3SYB3; 108-203.
DR   STRING; Q3SYB3; -.
DR   DMDM; 166214939; -.
DR   PRIDE; Q3SYB3; -.
DR   Ensembl; ENST00000377473; ENSP00000366693; ENSG00000204793.
DR   GeneID; 653404; -.
DR   KEGG; hsa:653404; -.
DR   UCSC; uc004afi.2; human.
DR   CTD; 653404; -.
DR   GeneCards; GC09M069199; -.
DR   HGNC; HGNC:31986; FOXD4L6.
DR   HPA; HPA012836; -.
DR   neXtProt; NX_Q3SYB3; -.
DR   PharmGKB; PA162388805; -.
DR   eggNOG; maNOG22278; -.
DR   HOGENOM; HBG125780; -.
DR   HOVERGEN; HBG051641; -.
DR   InParanoid; Q3SYB3; -.
DR   OrthoDB; EOG4JM7Q5; -.
DR   PhylomeDB; Q3SYB3; -.
DR   NextBio; 123194; -.
DR   CleanEx; HS_FOXD4L6; -.
DR   Genevestigator; Q3SYB3; -.
DR   GO; GO:0005667; C:transcription factor complex; IBA:RefGenome.
DR   GO; GO:0008301; F:DNA binding, bending; IBA:RefGenome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
DR   GO; GO:0010843; ?:promoter binding; IBA:RefGenome.
DR   GO; GO:0003705; F:sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; IBA:RefGenome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003704; ?:specific RNA polymerase II transcription factor activity; IBA:RefGenome.
DR   GO; GO:0016566; ?:specific transcriptional repressor activity; IBA:RefGenome.
DR   GO; GO:0016563; ?:transcription activator activity; IBA:RefGenome.
DR   GO; GO:0008134; F:transcription factor binding; IBA:RefGenome.
DR   GO; GO:0048846; P:axon extension involved in axon guidance; IBA:RefGenome.
DR   GO; GO:0051216; P:cartilage development; IBA:RefGenome.
DR   GO; GO:0060678; P:dichotomous subdivision of terminal units involved in ureteric bud branching; IBA:RefGenome.
DR   GO; GO:0009790; P:embryo development; IBA:RefGenome.
DR   GO; GO:0048484; P:enteric nervous system development; IBA:RefGenome.
DR   GO; GO:0050935; P:iridophore differentiation; IBA:RefGenome.
DR   GO; GO:0048937; P:lateral line nerve glial cell development; IBA:RefGenome.
DR   GO; GO:0030318; P:melanocyte differentiation; IBA:RefGenome.
DR   GO; GO:0001755; P:neural crest cell migration; IBA:RefGenome.
DR   GO; GO:0007389; P:pattern specification process; IBA:RefGenome.
DR   GO; GO:0007422; P:peripheral nervous system development; IBA:RefGenome.
DR   GO; GO:0030513; P:positive regulation of BMP signaling pathway; IBA:RefGenome.
DR   GO; GO:0090184; P:positive regulation of kidney development; IBA:RefGenome.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
DR   GO; GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
DR   GO; GO:0048485; P:sympathetic nervous system development; IBA:RefGenome.
DR   InterPro; IPR001766; TF_fork_head.
DR   InterPro; IPR018122; TF_fork_head_CS.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   KO; K09397; -.
DR   Pfam; PF00250; Fork_head; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    417       Forkhead box protein D4-like 6.
FT                                /FTId=PRO_0000301979.
FT   DNA_BIND    108    202       Fork-head.
FT   COMPBIAS    211    267       Pro-rich.
FT   CONFLICT    416    416       P -> R (in Ref. 2; CAI94919).
SQ   SEQUENCE   417 AA;  45787 MW;  0A21FCC4EC1D66CE CRC64;
     MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ
     VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
     ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
     YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
     APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
     PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
     ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC
//