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Q3SYB3

- FX4L6_HUMAN

UniProt

Q3SYB3 - FX4L6_HUMAN

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Protein
Forkhead box protein D4-like 6
Gene
FOXD4L6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 20295Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome

GO - Biological processi

  1. axon extension involved in axon guidance Source: RefGenome
  2. branching involved in ureteric bud morphogenesis Source: RefGenome
  3. cartilage development Source: RefGenome
  4. enteric nervous system development Source: RefGenome
  5. iridophore differentiation Source: RefGenome
  6. kidney development Source: RefGenome
  7. lateral line nerve glial cell development Source: RefGenome
  8. melanocyte differentiation Source: RefGenome
  9. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  10. neural crest cell migration Source: RefGenome
  11. pattern specification process Source: RefGenome
  12. peripheral nervous system development Source: RefGenome
  13. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  14. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  15. sympathetic nervous system development Source: RefGenome
  16. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 6
Short name:
FOXD4-like 6
Gene namesi
Name:FOXD4L6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:31986. FOXD4L6.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Forkhead box protein D4-like 6
PRO_0000301979Add
BLAST

Proteomic databases

PRIDEiQ3SYB3.

Expressioni

Gene expression databases

CleanExiHS_FOXD4L6.
GenevestigatoriQ3SYB3.

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

BioGridi575756. 1 interaction.
IntActiQ3SYB3. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3SYB3.
SMRiQ3SYB3. Positions 108-203.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 26757Pro-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ3SYB3.
KOiK09397.
OMAiLRACCTI.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ3SYB3.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SYB3-1 [UniParc]FASTAAdd to Basket

« Hide

MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF    50
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS 100
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP 150
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR 200
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY 250
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS 300
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG 350
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL 400
PPRARCWAGT CRPRRPC 417
Length:417
Mass (Da):45,787
Last modified:January 15, 2008 - v2
Checksum:i0A21FCC4EC1D66CE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti416 – 4161P → R in CAI94919. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX255923 Genomic DNA. Translation: CAI94919.1.
BC103887 mRNA. Translation: AAI03888.1.
BC137365 mRNA. Translation: AAI37366.1.
BC137366 mRNA. Translation: AAI37367.1.
CCDSiCCDS43826.1.
RefSeqiNP_001078945.1. NM_001085476.1.
UniGeneiHs.652377.

Genome annotation databases

EnsembliENST00000377473; ENSP00000366693; ENSG00000204793.
GeneIDi653404.
KEGGihsa:653404.
UCSCiuc004afi.2. human.

Polymorphism databases

DMDMi166214939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX255923 Genomic DNA. Translation: CAI94919.1 .
BC103887 mRNA. Translation: AAI03888.1 .
BC137365 mRNA. Translation: AAI37366.1 .
BC137366 mRNA. Translation: AAI37367.1 .
CCDSi CCDS43826.1.
RefSeqi NP_001078945.1. NM_001085476.1.
UniGenei Hs.652377.

3D structure databases

ProteinModelPortali Q3SYB3.
SMRi Q3SYB3. Positions 108-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 575756. 1 interaction.
IntActi Q3SYB3. 2 interactions.

Polymorphism databases

DMDMi 166214939.

Proteomic databases

PRIDEi Q3SYB3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377473 ; ENSP00000366693 ; ENSG00000204793 .
GeneIDi 653404.
KEGGi hsa:653404.
UCSCi uc004afi.2. human.

Organism-specific databases

CTDi 653404.
GeneCardsi GC09M069199.
HGNCi HGNC:31986. FOXD4L6.
HPAi HPA012836.
neXtProti NX_Q3SYB3.
PharmGKBi PA162388805.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000231285.
HOVERGENi HBG051641.
InParanoidi Q3SYB3.
KOi K09397.
OMAi LRACCTI.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q3SYB3.
TreeFami TF316127.

Miscellaneous databases

GenomeRNAii 653404.
NextBioi 123194.
PROi Q3SYB3.

Gene expression databases

CleanExi HS_FOXD4L6.
Genevestigatori Q3SYB3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiFX4L6_HUMAN
AccessioniPrimary (citable) accession number: Q3SYB3
Secondary accession number(s): B2RPC4, Q4V336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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