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Protein

Forkhead box protein D4-like 6

Gene

FOXD4L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 202Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 6
Short name:
FOXD4-like 6
Gene namesi
Name:FOXD4L6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000273514.1.
HGNCiHGNC:31986. FOXD4L6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000273514.
PharmGKBiPA162388805.

Polymorphism and mutation databases

BioMutaiFOXD4L6.
DMDMi166214939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019791 – 417Forkhead box protein D4-like 6Add BLAST417

Proteomic databases

PaxDbiQ3SYB3.
PeptideAtlasiQ3SYB3.
PRIDEiQ3SYB3.

PTM databases

iPTMnetiQ3SYB3.
PhosphoSitePlusiQ3SYB3.

Expressioni

Gene expression databases

BgeeiENSG00000273514.
CleanExiHS_FOXD4L6.

Organism-specific databases

HPAiHPA012836.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997505EBI-6425864,EBI-724076

Protein-protein interaction databases

BioGridi575756. 20 interactors.
IntActiQ3SYB3. 11 interactors.
STRINGi9606.ENSP00000366693.

Structurei

3D structure databases

ProteinModelPortaliQ3SYB3.
SMRiQ3SYB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 267Pro-richAdd BLAST57

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ3SYB3.
KOiK09397.
OMAiRPCALLH.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ3SYB3.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SYB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL
410
PPRARCWAGT CRPRRPC
Length:417
Mass (Da):45,787
Last modified:January 15, 2008 - v2
Checksum:i0A21FCC4EC1D66CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416P → R in CAI94919 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255923 Genomic DNA. Translation: CAI94919.1.
BC103887 mRNA. Translation: AAI03888.1.
BC137365 mRNA. Translation: AAI37366.1.
BC137366 mRNA. Translation: AAI37367.1.
CCDSiCCDS43826.1.
RefSeqiNP_001078945.1. NM_001085476.1.
UniGeneiHs.652377.

Genome annotation databases

EnsembliENST00000622588; ENSP00000484875; ENSG00000273514.
GeneIDi653404.
KEGGihsa:653404.
UCSCiuc004afi.3. human.

Similar proteinsi

Entry informationi

Entry nameiFX4L6_HUMAN
AccessioniPrimary (citable) accession number: Q3SYB3
Secondary accession number(s): B2RPC4, Q4V336
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 15, 2008
Last modified: September 27, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM