Q3SYB3 (FX4L6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein D4-like 6
Short name=FOXD4-like 6

Gene names

Name:

FOXD4L6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Miscellaneous	5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Uncategorized	promoter binding Inferred from Biological aspect of Ancestor. Source: RefGenome specific RNA polymerase II transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome specific transcriptional repressor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Biological process	axon extension involved in axon guidance Inferred from Biological aspect of Ancestor. Source: RefGenome cartilage development Inferred from Biological aspect of Ancestor. Source: RefGenome dichotomous subdivision of terminal units involved in ureteric bud branching Inferred from Biological aspect of Ancestor. Source: RefGenome embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome enteric nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome iridophore differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome lateral line nerve glial cell development Inferred from Biological aspect of Ancestor. Source: RefGenome melanocyte differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome neural crest cell migration Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome peripheral nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of BMP signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of kidney development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome sympathetic nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific distal enhancer binding RNA polymerase II transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Forkhead box protein D4-like 6		PRO_0000301979
Regions
	DNA binding	108 – 202	95	Fork-head
	Compositional bias	211 – 267	57	Pro-rich
Experimental info
	Sequence conflict	416	1	P → R in CAI94919. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3SYB3 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 0A21FCC4EC1D66CE	FASTA	417	45,787
	10 20 30 40 50 60 MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ 70 80 90 100 110 120 VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA 130 140 150 160 170 180 ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN 190 200 210 220 230 240 YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP 250 260 270 280 290 300 APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS 310 320 330 340 350 360 PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ 370 380 390 400 410 ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX255923 Genomic DNA. Translation: CAI94919.1. BC103887 mRNA. Translation: AAI03888.1. BC137365 mRNA. Translation: AAI37366.1. BC137366 mRNA. Translation: AAI37367.1.
IPI	IPI00654829.
RefSeq	NP_001078945.1. NM_001085476.1.
UniGene	Hs.652377.
3D structure databases
HSSP	HSSP built from PDB template 2C6Y based on UniProtKB Q01167.
ProteinModelPortal	Q3SYB3.
SMR	Q3SYB3. Positions 108-203.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SYB3.
Polymorphism databases
DMDM	166214939.
Proteomic databases
PRIDE	Q3SYB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377473; ENSP00000366693; ENSG00000204793.
GeneID	653404.
KEGG	hsa:653404.
UCSC	uc004afi.2. human.
Organism-specific databases
CTD	653404.
GeneCards	GC09M069199.
HGNC	HGNC:31986. FOXD4L6.
HPA	HPA012836.
neXtProt	NX_Q3SYB3.
PharmGKB	PA162388805.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00650000093003.
HOGENOM	HOG000231285.
HOVERGEN	HBG051641.
InParanoid	Q3SYB3.
KO	K09397.
OrthoDB	EOG4JM7Q5.
Gene expression databases
CleanEx	HS_FOXD4L6.
Genevestigator	Q3SYB3.
Family and domain databases
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	123194.

Entry information

Entry name

FX4L6_HUMAN

Accession

Primary (citable) accession number: Q3SYB3
Secondary accession number(s): B2RPC4, Q4V336

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 15, 2008
Last modified:	May 16, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.