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Protein

Forkhead box protein D4-like 6

Gene

FOXD4L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 20295Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 6
Short name:
FOXD4-like 6
Gene namesi
Name:FOXD4L6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31986. FOXD4L6.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388805.

Polymorphism and mutation databases

BioMutaiFOXD4L6.
DMDMi166214939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Forkhead box protein D4-like 6PRO_0000301979Add
BLAST

Proteomic databases

PRIDEiQ3SYB3.

Expressioni

Gene expression databases

CleanExiHS_FOXD4L6.

Organism-specific databases

HPAiHPA012836.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-6425864,EBI-724076

Protein-protein interaction databases

BioGridi575756. 19 interactions.
IntActiQ3SYB3. 11 interactions.
STRINGi9606.ENSP00000366693.

Structurei

3D structure databases

ProteinModelPortaliQ3SYB3.
SMRiQ3SYB3. Positions 108-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 26757Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ3SYB3.
KOiK09397.
OMAiLRACCTI.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ3SYB3.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SYB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL
410
PPRARCWAGT CRPRRPC
Length:417
Mass (Da):45,787
Last modified:January 15, 2008 - v2
Checksum:i0A21FCC4EC1D66CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti416 – 4161P → R in CAI94919 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255923 Genomic DNA. Translation: CAI94919.1.
BC103887 mRNA. Translation: AAI03888.1.
BC137365 mRNA. Translation: AAI37366.1.
BC137366 mRNA. Translation: AAI37367.1.
CCDSiCCDS43826.1.
RefSeqiNP_001078945.1. NM_001085476.1.
UniGeneiHs.652377.

Genome annotation databases

EnsembliENST00000622588; ENSP00000484875; ENSG00000273514.
GeneIDi653404.
KEGGihsa:653404.
UCSCiuc004afi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255923 Genomic DNA. Translation: CAI94919.1.
BC103887 mRNA. Translation: AAI03888.1.
BC137365 mRNA. Translation: AAI37366.1.
BC137366 mRNA. Translation: AAI37367.1.
CCDSiCCDS43826.1.
RefSeqiNP_001078945.1. NM_001085476.1.
UniGeneiHs.652377.

3D structure databases

ProteinModelPortaliQ3SYB3.
SMRiQ3SYB3. Positions 108-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575756. 19 interactions.
IntActiQ3SYB3. 11 interactions.
STRINGi9606.ENSP00000366693.

Polymorphism and mutation databases

BioMutaiFOXD4L6.
DMDMi166214939.

Proteomic databases

PRIDEiQ3SYB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622588; ENSP00000484875; ENSG00000273514.
GeneIDi653404.
KEGGihsa:653404.
UCSCiuc004afi.2. human.

Organism-specific databases

CTDi653404.
GeneCardsiGC09M069199.
HGNCiHGNC:31986. FOXD4L6.
HPAiHPA012836.
neXtProtiNX_Q3SYB3.
PharmGKBiPA162388805.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ3SYB3.
KOiK09397.
OMAiLRACCTI.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ3SYB3.
TreeFamiTF316127.

Miscellaneous databases

GenomeRNAii653404.
NextBioi123194.
PROiQ3SYB3.

Gene expression databases

CleanExiHS_FOXD4L6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiFX4L6_HUMAN
AccessioniPrimary (citable) accession number: Q3SYB3
Secondary accession number(s): B2RPC4, Q4V336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 15, 2008
Last modified: June 24, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.