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Q3SY77

- UD3A2_HUMAN

UniProt

Q3SY77 - UD3A2_HUMAN

Protein

UDP-glucuronosyltransferase 3A2

Gene

UGT3A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC
    2. UDP-glycosyltransferase activity Source: MGI

    GO - Biological processi

    1. cellular response to genistein Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 3A2 (EC:2.4.1.17)
    Short name:
    UDPGT 3A2
    Gene namesi
    Name:UGT3A2
    ORF Names:PSEC0073, UNQ842/PRO1780
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:27266. UGT3A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670643.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 523501UDP-glucuronosyltransferase 3A2PRO_0000299153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ3SY77.
    PRIDEiQ3SY77.

    PTM databases

    PhosphoSiteiQ3SY77.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3SY77.
    BgeeiQ3SY77.
    CleanExiHS_UGT3A2.
    GenevestigatoriQ3SY77.

    Organism-specific databases

    HPAiHPA059475.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000282507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SY77.
    SMRiQ3SY77. Positions 277-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 483461ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG326467.
    HOGENOMiHOG000220831.
    HOVERGENiHBG106370.
    InParanoidiQ3SY77.
    OMAiIFKEMNN.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiQ3SY77.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3SY77-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGQRVLLLV GFLLPGVLLS EAAKILTIST VGGSHYLLMD RVSQILQDHG    50
    HNVTMLNHKR GPFMPDFKKE EKSYQVISWL APEDHQREFK KSFDFFLEET 100
    LGGRGKFENL LNVLEYLALQ CSHFLNRKDI MDSLKNENFD MVIVETFDYC 150
    PFLIAEKLGK PFVAILSTSF GSLEFGLPIP LSYVPVFRSL LTDHMDFWGR 200
    VKNFLMFFSF CRRQQHMQST FDNTIKEHFT EGSRPVLSHL LLKAELWFIN 250
    SDFAFDFARP LLPNTVYVGG LMEKPIKPVP QDLENFIAKF GDSGFVLVTL 300
    GSMVNTCQNP EIFKEMNNAF AHLPQGVIWK CQCSHWPKDV HLAANVKIVD 350
    WLPQSDLLAH PSIRLFVTHG GQNSIMEAIQ HGVPMVGIPL FGDQPENMVR 400
    VEAKKFGVSI QLKKLKAETL ALKMKQIMED KRYKSAAVAA SVILRSHPLS 450
    PTQRLVGWID HVLQTGGATH LKPYVFQQPW HEQYLLDVFV FLLGLTLGTL 500
    WLCGKLLGMA VWWLRGARKV KET 523
    Length:523
    Mass (Da):59,547
    Last modified:October 11, 2005 - v1
    Checksum:iDFE9CD92D1F5AF6F
    GO
    Isoform 2 (identifier: Q3SY77-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-65: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:489
    Mass (Da):55,677
    Checksum:i3D091C66AD084274
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti291 – 2911G → E in BAC11583. (PubMed:16303743)Curated
    Sequence conflicti311 – 3111E → G in BAG62419. (PubMed:14702039)Curated
    Sequence conflicti486 – 4861L → F in AAQ88782. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741Y → N.
    Corresponds to variant rs2197514 [ dbSNP | Ensembl ].
    VAR_057329
    Natural varianti515 – 5151R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036036

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 6534Missing in isoform 2. 1 PublicationVSP_046099Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358416 mRNA. Translation: AAQ88782.1.
    AK300751 mRNA. Translation: BAG62419.1.
    AK075383 mRNA. Translation: BAC11583.1.
    AC016612 Genomic DNA. No translation available.
    BC103924 mRNA. Translation: AAI03925.1.
    BC103925 mRNA. Translation: AAI03926.1.
    CCDSiCCDS3914.1. [Q3SY77-1]
    CCDS54842.1. [Q3SY77-2]
    RefSeqiNP_001161788.1. NM_001168316.1. [Q3SY77-2]
    NP_777574.2. NM_174914.3. [Q3SY77-1]
    UniGeneiHs.348941.

    Genome annotation databases

    EnsembliENST00000282507; ENSP00000282507; ENSG00000168671. [Q3SY77-1]
    ENST00000513300; ENSP00000427404; ENSG00000168671. [Q3SY77-2]
    GeneIDi167127.
    KEGGihsa:167127.
    UCSCiuc003jjz.2. human. [Q3SY77-1]

    Polymorphism databases

    DMDMi121942966.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358416 mRNA. Translation: AAQ88782.1 .
    AK300751 mRNA. Translation: BAG62419.1 .
    AK075383 mRNA. Translation: BAC11583.1 .
    AC016612 Genomic DNA. No translation available.
    BC103924 mRNA. Translation: AAI03925.1 .
    BC103925 mRNA. Translation: AAI03926.1 .
    CCDSi CCDS3914.1. [Q3SY77-1 ]
    CCDS54842.1. [Q3SY77-2 ]
    RefSeqi NP_001161788.1. NM_001168316.1. [Q3SY77-2 ]
    NP_777574.2. NM_174914.3. [Q3SY77-1 ]
    UniGenei Hs.348941.

    3D structure databases

    ProteinModelPortali Q3SY77.
    SMRi Q3SY77. Positions 277-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000282507.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q3SY77.

    Polymorphism databases

    DMDMi 121942966.

    Proteomic databases

    PaxDbi Q3SY77.
    PRIDEi Q3SY77.

    Protocols and materials databases

    DNASUi 167127.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282507 ; ENSP00000282507 ; ENSG00000168671 . [Q3SY77-1 ]
    ENST00000513300 ; ENSP00000427404 ; ENSG00000168671 . [Q3SY77-2 ]
    GeneIDi 167127.
    KEGGi hsa:167127.
    UCSCi uc003jjz.2. human. [Q3SY77-1 ]

    Organism-specific databases

    CTDi 167127.
    GeneCardsi GC05M035985.
    H-InvDB HIX0032013.
    HGNCi HGNC:27266. UGT3A2.
    HPAi HPA059475.
    neXtProti NX_Q3SY77.
    PharmGKBi PA142670643.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326467.
    HOGENOMi HOG000220831.
    HOVERGENi HBG106370.
    InParanoidi Q3SY77.
    OMAi IFKEMNN.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi Q3SY77.
    TreeFami TF315472.

    Miscellaneous databases

    ChiTaRSi UGT3A2. human.
    GenomeRNAii 167127.
    NextBioi 88655.
    PROi Q3SY77.

    Gene expression databases

    ArrayExpressi Q3SY77.
    Bgeei Q3SY77.
    CleanExi HS_UGT3A2.
    Genevestigatori Q3SY77.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-515.

    Entry informationi

    Entry nameiUD3A2_HUMAN
    AccessioniPrimary (citable) accession number: Q3SY77
    Secondary accession number(s): B4DUQ7
    , E9PFK7, Q6UXC4, Q8NBP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3