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Protein

UDP-glucuronosyltransferase 3A2

Gene

UGT3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB-EC
  • UDP-glycosyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS09801-MONOMER.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A2 (EC:2.4.1.17)
Short name:
UDPGT 3A2
Gene namesi
Name:UGT3A2
ORF Names:PSEC0073, UNQ842/PRO1780
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:27266. UGT3A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 483ExtracellularSequence analysisAdd BLAST461
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 523CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi167127.
OpenTargetsiENSG00000168671.
PharmGKBiPA142670643.

Polymorphism and mutation databases

BioMutaiUGT3A2.
DMDMi121942966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029915323 – 523UDP-glucuronosyltransferase 3A2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ3SY77.
PaxDbiQ3SY77.
PeptideAtlasiQ3SY77.
PRIDEiQ3SY77.

PTM databases

iPTMnetiQ3SY77.
PhosphoSitePlusiQ3SY77.

Expressioni

Gene expression databases

BgeeiENSG00000168671.
CleanExiHS_UGT3A2.
ExpressionAtlasiQ3SY77. baseline and differential.

Organism-specific databases

HPAiHPA059475.

Interactioni

Protein-protein interaction databases

BioGridi127942. 7 interactors.
STRINGi9606.ENSP00000282507.

Structurei

3D structure databases

ProteinModelPortaliQ3SY77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ3SY77.
OMAiIFKEMNN.
OrthoDBiEOG091G06JC.
PhylomeDBiQ3SY77.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3SY77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGQRVLLLV GFLLPGVLLS EAAKILTIST VGGSHYLLMD RVSQILQDHG
60 70 80 90 100
HNVTMLNHKR GPFMPDFKKE EKSYQVISWL APEDHQREFK KSFDFFLEET
110 120 130 140 150
LGGRGKFENL LNVLEYLALQ CSHFLNRKDI MDSLKNENFD MVIVETFDYC
160 170 180 190 200
PFLIAEKLGK PFVAILSTSF GSLEFGLPIP LSYVPVFRSL LTDHMDFWGR
210 220 230 240 250
VKNFLMFFSF CRRQQHMQST FDNTIKEHFT EGSRPVLSHL LLKAELWFIN
260 270 280 290 300
SDFAFDFARP LLPNTVYVGG LMEKPIKPVP QDLENFIAKF GDSGFVLVTL
310 320 330 340 350
GSMVNTCQNP EIFKEMNNAF AHLPQGVIWK CQCSHWPKDV HLAANVKIVD
360 370 380 390 400
WLPQSDLLAH PSIRLFVTHG GQNSIMEAIQ HGVPMVGIPL FGDQPENMVR
410 420 430 440 450
VEAKKFGVSI QLKKLKAETL ALKMKQIMED KRYKSAAVAA SVILRSHPLS
460 470 480 490 500
PTQRLVGWID HVLQTGGATH LKPYVFQQPW HEQYLLDVFV FLLGLTLGTL
510 520
WLCGKLLGMA VWWLRGARKV KET
Length:523
Mass (Da):59,547
Last modified:October 11, 2005 - v1
Checksum:iDFE9CD92D1F5AF6F
GO
Isoform 2 (identifier: Q3SY77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-65: Missing.

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):55,677
Checksum:i3D091C66AD084274
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291G → E in BAC11583 (PubMed:16303743).Curated1
Sequence conflicti311E → G in BAG62419 (PubMed:14702039).Curated1
Sequence conflicti486L → F in AAQ88782 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05732974Y → N.Corresponds to variant rs2197514dbSNPEnsembl.1
Natural variantiVAR_036036515R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs138640717dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04609932 – 65Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358416 mRNA. Translation: AAQ88782.1.
AK300751 mRNA. Translation: BAG62419.1.
AK075383 mRNA. Translation: BAC11583.1.
AC016612 Genomic DNA. No translation available.
BC103924 mRNA. Translation: AAI03925.1.
BC103925 mRNA. Translation: AAI03926.1.
CCDSiCCDS3914.1. [Q3SY77-1]
CCDS54842.1. [Q3SY77-2]
RefSeqiNP_001161788.1. NM_001168316.1. [Q3SY77-2]
NP_777574.2. NM_174914.3. [Q3SY77-1]
UniGeneiHs.348941.

Genome annotation databases

EnsembliENST00000282507; ENSP00000282507; ENSG00000168671. [Q3SY77-1]
ENST00000513300; ENSP00000427404; ENSG00000168671. [Q3SY77-2]
GeneIDi167127.
KEGGihsa:167127.
UCSCiuc003jjz.3. human. [Q3SY77-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358416 mRNA. Translation: AAQ88782.1.
AK300751 mRNA. Translation: BAG62419.1.
AK075383 mRNA. Translation: BAC11583.1.
AC016612 Genomic DNA. No translation available.
BC103924 mRNA. Translation: AAI03925.1.
BC103925 mRNA. Translation: AAI03926.1.
CCDSiCCDS3914.1. [Q3SY77-1]
CCDS54842.1. [Q3SY77-2]
RefSeqiNP_001161788.1. NM_001168316.1. [Q3SY77-2]
NP_777574.2. NM_174914.3. [Q3SY77-1]
UniGeneiHs.348941.

3D structure databases

ProteinModelPortaliQ3SY77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127942. 7 interactors.
STRINGi9606.ENSP00000282507.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ3SY77.
PhosphoSitePlusiQ3SY77.

Polymorphism and mutation databases

BioMutaiUGT3A2.
DMDMi121942966.

Proteomic databases

EPDiQ3SY77.
PaxDbiQ3SY77.
PeptideAtlasiQ3SY77.
PRIDEiQ3SY77.

Protocols and materials databases

DNASUi167127.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282507; ENSP00000282507; ENSG00000168671. [Q3SY77-1]
ENST00000513300; ENSP00000427404; ENSG00000168671. [Q3SY77-2]
GeneIDi167127.
KEGGihsa:167127.
UCSCiuc003jjz.3. human. [Q3SY77-1]

Organism-specific databases

CTDi167127.
DisGeNETi167127.
GeneCardsiUGT3A2.
H-InvDBHIX0032013.
HGNCiHGNC:27266. UGT3A2.
HPAiHPA059475.
MIMi616384. gene.
neXtProtiNX_Q3SY77.
OpenTargetsiENSG00000168671.
PharmGKBiPA142670643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ3SY77.
OMAiIFKEMNN.
OrthoDBiEOG091G06JC.
PhylomeDBiQ3SY77.
TreeFamiTF315472.

Enzyme and pathway databases

BioCyciZFISH:HS09801-MONOMER.

Miscellaneous databases

ChiTaRSiUGT3A2. human.
GenomeRNAii167127.
PROiQ3SY77.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168671.
CleanExiHS_UGT3A2.
ExpressionAtlasiQ3SY77. baseline and differential.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD3A2_HUMAN
AccessioniPrimary (citable) accession number: Q3SY77
Secondary accession number(s): B4DUQ7
, E9PFK7, Q6UXC4, Q8NBP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.