Reviewed,
UniProtKB/Swiss-Prot Q3SY77 (UD3A2_HUMAN)
Last modified
July 7, 2009.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucuronosyltransferase 3A2 Short name=UDPGT 3A2 EC=2.4.1.17 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 523 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity. |
| Catalytic activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Subcellular location | Membrane; Single-pass type I membrane protein Potential. |
| Sequence similarities | Belongs to the UDP-glycosyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | glucuronosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 523 | 501 | UDP-glucuronosyltransferase 3A2 | PRO_0000299153 | |||||
Regions | |||||||||
| Topological domain | 23 – 483 | 461 | Extracellular Potential | ||||||
| Transmembrane | 484 – 504 | 21 | Potential | ||||||
| Topological domain | 505 – 523 | 19 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 52 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 74 | 1 | Y → N: dbSNP rs2197514. | VAR_057329 | |||||
| Natural variant | 515 | 1 | R → H in a colorectal cancer sample; somatic mutation. Ref.4 | VAR_036036 | |||||
Experimental info | |||||||||
| Sequence conflict | 291 | 1 | G → E in BAC11583. Ref.2 | ||||||
| Sequence conflict | 486 | 1 | L → F in AAQ88782. Ref.1 | ||||||
Sequences
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References
| [1] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. Isogai T.DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-515. |
Cross-references
Sequence databases | |
|---|---|
| AY358416 mRNA. Translation: AAQ88782.1. AK075383 mRNA. Translation: BAC11583.1. BC103924 mRNA. Translation: AAI03925.1. BC103925 mRNA. Translation: AAI03926.1. | |
| IPI | IPI00168291. |
| RefSeq | NP_777574.1. |
| UniGene | Hs.348941 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT1. Glycosyltransferase Family 1. |
Proteomic databases | |
| PRIDE | Q3SY77. |
Genome annotation databases | |
| Ensembl | ENSG00000168671. Homo sapiens. [Contig view] |
| GeneID | 167127. |
| KEGG | hsa:167127. |
| NMPDR | fig|9606.3.peg.25144. |
| UCSC | uc003jjz.1. human. |
Organism-specific databases | |
| GeneCards | GC05M036071. |
| HGNC | HGNC:27266. UGT3A2. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q3SY77. |
| HOVERGEN | Q3SY77. |
| OMA | Q3SY77. VISWLAP. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.17. 247. |
Gene expression databases | |
| ArrayExpress | Q3SY77. |
| Bgee | Q3SY77. |
| CleanEx | HS_UGT3A2. |
Family and domain databases | |
| InterPro | IPR002213. UDP_glucos_trans. [Graphical view] |
| PANTHER | PTHR11926. UDP_glucos_trans. 1 hit. |
| Pfam | PF00201. UDPGT. 1 hit. [Graphical view] |
| PROSITE | PS00375. UDPGT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 88655. |
Entry information
| Entry name | UD3A2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q3SY77 Secondary accession number(s): Q6UXC4, Q8NBP2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


