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Q3SY77

- UD3A2_HUMAN

UniProt

Q3SY77 - UD3A2_HUMAN

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Protein

UDP-glucuronosyltransferase 3A2

Gene

UGT3A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
  2. UDP-glycosyltransferase activity Source: MGI

GO - Biological processi

  1. cellular response to genistein Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A2 (EC:2.4.1.17)
Short name:
UDPGT 3A2
Gene namesi
Name:UGT3A2
ORF Names:PSEC0073, UNQ842/PRO1780
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:27266. UGT3A2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 523501UDP-glucuronosyltransferase 3A2PRO_0000299153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3SY77.
PRIDEiQ3SY77.

PTM databases

PhosphoSiteiQ3SY77.

Expressioni

Gene expression databases

BgeeiQ3SY77.
CleanExiHS_UGT3A2.
ExpressionAtlasiQ3SY77. baseline and differential.
GenevestigatoriQ3SY77.

Organism-specific databases

HPAiHPA059475.

Interactioni

Protein-protein interaction databases

BioGridi127942. 2 interactions.
STRINGi9606.ENSP00000282507.

Structurei

3D structure databases

ProteinModelPortaliQ3SY77.
SMRiQ3SY77. Positions 277-441.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 483461ExtracellularSequence AnalysisAdd
BLAST
Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG326467.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ3SY77.
OMAiIFKEMNN.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ3SY77.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3SY77-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGQRVLLLV GFLLPGVLLS EAAKILTIST VGGSHYLLMD RVSQILQDHG
60 70 80 90 100
HNVTMLNHKR GPFMPDFKKE EKSYQVISWL APEDHQREFK KSFDFFLEET
110 120 130 140 150
LGGRGKFENL LNVLEYLALQ CSHFLNRKDI MDSLKNENFD MVIVETFDYC
160 170 180 190 200
PFLIAEKLGK PFVAILSTSF GSLEFGLPIP LSYVPVFRSL LTDHMDFWGR
210 220 230 240 250
VKNFLMFFSF CRRQQHMQST FDNTIKEHFT EGSRPVLSHL LLKAELWFIN
260 270 280 290 300
SDFAFDFARP LLPNTVYVGG LMEKPIKPVP QDLENFIAKF GDSGFVLVTL
310 320 330 340 350
GSMVNTCQNP EIFKEMNNAF AHLPQGVIWK CQCSHWPKDV HLAANVKIVD
360 370 380 390 400
WLPQSDLLAH PSIRLFVTHG GQNSIMEAIQ HGVPMVGIPL FGDQPENMVR
410 420 430 440 450
VEAKKFGVSI QLKKLKAETL ALKMKQIMED KRYKSAAVAA SVILRSHPLS
460 470 480 490 500
PTQRLVGWID HVLQTGGATH LKPYVFQQPW HEQYLLDVFV FLLGLTLGTL
510 520
WLCGKLLGMA VWWLRGARKV KET
Length:523
Mass (Da):59,547
Last modified:October 11, 2005 - v1
Checksum:iDFE9CD92D1F5AF6F
GO
Isoform 2 (identifier: Q3SY77-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-65: Missing.

Note: No experimental confirmation available.

Show »
Length:489
Mass (Da):55,677
Checksum:i3D091C66AD084274
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911G → E in BAC11583. (PubMed:16303743)Curated
Sequence conflicti311 – 3111E → G in BAG62419. (PubMed:14702039)Curated
Sequence conflicti486 – 4861L → F in AAQ88782. (PubMed:12975309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti74 – 741Y → N.
Corresponds to variant rs2197514 [ dbSNP | Ensembl ].
VAR_057329
Natural varianti515 – 5151R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036036

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 6534Missing in isoform 2. 1 PublicationVSP_046099Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358416 mRNA. Translation: AAQ88782.1.
AK300751 mRNA. Translation: BAG62419.1.
AK075383 mRNA. Translation: BAC11583.1.
AC016612 Genomic DNA. No translation available.
BC103924 mRNA. Translation: AAI03925.1.
BC103925 mRNA. Translation: AAI03926.1.
CCDSiCCDS3914.1. [Q3SY77-1]
CCDS54842.1. [Q3SY77-2]
RefSeqiNP_001161788.1. NM_001168316.1. [Q3SY77-2]
NP_777574.2. NM_174914.3. [Q3SY77-1]
UniGeneiHs.348941.

Genome annotation databases

EnsembliENST00000282507; ENSP00000282507; ENSG00000168671. [Q3SY77-1]
ENST00000513300; ENSP00000427404; ENSG00000168671. [Q3SY77-2]
GeneIDi167127.
KEGGihsa:167127.
UCSCiuc003jjz.2. human. [Q3SY77-1]

Polymorphism databases

DMDMi121942966.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358416 mRNA. Translation: AAQ88782.1 .
AK300751 mRNA. Translation: BAG62419.1 .
AK075383 mRNA. Translation: BAC11583.1 .
AC016612 Genomic DNA. No translation available.
BC103924 mRNA. Translation: AAI03925.1 .
BC103925 mRNA. Translation: AAI03926.1 .
CCDSi CCDS3914.1. [Q3SY77-1 ]
CCDS54842.1. [Q3SY77-2 ]
RefSeqi NP_001161788.1. NM_001168316.1. [Q3SY77-2 ]
NP_777574.2. NM_174914.3. [Q3SY77-1 ]
UniGenei Hs.348941.

3D structure databases

ProteinModelPortali Q3SY77.
SMRi Q3SY77. Positions 277-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127942. 2 interactions.
STRINGi 9606.ENSP00000282507.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q3SY77.

Polymorphism databases

DMDMi 121942966.

Proteomic databases

PaxDbi Q3SY77.
PRIDEi Q3SY77.

Protocols and materials databases

DNASUi 167127.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282507 ; ENSP00000282507 ; ENSG00000168671 . [Q3SY77-1 ]
ENST00000513300 ; ENSP00000427404 ; ENSG00000168671 . [Q3SY77-2 ]
GeneIDi 167127.
KEGGi hsa:167127.
UCSCi uc003jjz.2. human. [Q3SY77-1 ]

Organism-specific databases

CTDi 167127.
GeneCardsi GC05M035985.
H-InvDB HIX0032013.
HGNCi HGNC:27266. UGT3A2.
HPAi HPA059475.
neXtProti NX_Q3SY77.
PharmGKBi PA142670643.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326467.
GeneTreei ENSGT00760000118949.
HOGENOMi HOG000220831.
HOVERGENi HBG106370.
InParanoidi Q3SY77.
OMAi IFKEMNN.
OrthoDBi EOG7GBFWS.
PhylomeDBi Q3SY77.
TreeFami TF315472.

Miscellaneous databases

ChiTaRSi UGT3A2. human.
GenomeRNAii 167127.
NextBioi 88655.
PROi Q3SY77.

Gene expression databases

Bgeei Q3SY77.
CleanExi HS_UGT3A2.
ExpressionAtlasi Q3SY77. baseline and differential.
Genevestigatori Q3SY77.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-515.

Entry informationi

Entry nameiUD3A2_HUMAN
AccessioniPrimary (citable) accession number: Q3SY77
Secondary accession number(s): B4DUQ7
, E9PFK7, Q6UXC4, Q8NBP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3