Q3SY77 (UD3A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-glucuronosyltransferase 3A2
Short name=UDPGT 3A2
EC=2.4.1.17

Gene names

Name:	UGT3A2
ORF Names:	PSEC0073, UNQ842/PRO1780

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 523	501	UDP-glucuronosyltransferase 3A2		PRO_0000299153
Regions
	Topological domain	23 – 483	461	Extracellular Potential
	Transmembrane	484 – 504	21	Helical; Potential
	Topological domain	505 – 523	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	74	1	Y → N. Corresponds to variant rs2197514 [ dbSNP | Ensembl ].		VAR_057329
	Natural variant	515	1	R → H in a colorectal cancer sample; somatic mutation. Ref.4		VAR_036036
Experimental info
	Sequence conflict	291	1	G → E in BAC11583. Ref.2
	Sequence conflict	486	1	L → F in AAQ88782. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q3SY77 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: DFE9CD92D1F5AF6F	FASTA	523	59,547
	10 20 30 40 50 60 MAGQRVLLLV GFLLPGVLLS EAAKILTIST VGGSHYLLMD RVSQILQDHG HNVTMLNHKR 70 80 90 100 110 120 GPFMPDFKKE EKSYQVISWL APEDHQREFK KSFDFFLEET LGGRGKFENL LNVLEYLALQ 130 140 150 160 170 180 CSHFLNRKDI MDSLKNENFD MVIVETFDYC PFLIAEKLGK PFVAILSTSF GSLEFGLPIP 190 200 210 220 230 240 LSYVPVFRSL LTDHMDFWGR VKNFLMFFSF CRRQQHMQST FDNTIKEHFT EGSRPVLSHL 250 260 270 280 290 300 LLKAELWFIN SDFAFDFARP LLPNTVYVGG LMEKPIKPVP QDLENFIAKF GDSGFVLVTL 310 320 330 340 350 360 GSMVNTCQNP EIFKEMNNAF AHLPQGVIWK CQCSHWPKDV HLAANVKIVD WLPQSDLLAH 370 380 390 400 410 420 PSIRLFVTHG GQNSIMEAIQ HGVPMVGIPL FGDQPENMVR VEAKKFGVSI QLKKLKAETL 430 440 450 460 470 480 ALKMKQIMED KRYKSAAVAA SVILRSHPLS PTQRLVGWID HVLQTGGATH LKPYVFQQPW 490 500 510 520 HEQYLLDVFV FLLGLTLGTL WLCGKLLGMA VWWLRGARKV KET

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-515.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358416 mRNA. Translation: AAQ88782.1. AK075383 mRNA. Translation: BAC11583.1. BC103924 mRNA. Translation: AAI03925.1. BC103925 mRNA. Translation: AAI03926.1.
IPI	IPI00168291.
RefSeq	NP_001161788.1. NM_001168316.1. NP_777574.2. NM_174914.3.
UniGene	Hs.348941.
3D structure databases
ProteinModelPortal	Q3SY77.
SMR	Q3SY77. Positions 32-60, 274-446.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SY77.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Polymorphism databases
DMDM	121942966.
Proteomic databases
PRIDE	Q3SY77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282507; ENSP00000282507; ENSG00000168671.
GeneID	167127.
KEGG	hsa:167127.
NMPDR	fig|9606.3.peg.25144.
UCSC	uc003jjz.1. human.
Organism-specific databases
CTD	167127.
GeneCards	GC05M035985.
HGNC	HGNC:27266. UGT3A2.
neXtProt	NX_Q3SY77.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13683.
GeneTree	ENSGT00560000076760.
HOGENOM	HBG446523.
HOVERGEN	HBG106370.
InParanoid	Q3SY77.
OMA	PFLIAEK.
OrthoDB	EOG4QZ7M2.
PhylomeDB	Q3SY77.
Gene expression databases
ArrayExpress	Q3SY77.
Bgee	Q3SY77.
CleanEx	HS_UGT3A2.
Genevestigator	Q3SY77.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	88655.

Entry information

Entry name

UD3A2_HUMAN

Accession

Primary (citable) accession number: Q3SY77
Secondary accession number(s): Q6UXC4, Q8NBP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 11, 2005
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.