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Protein

Transcription factor Sp6

Gene

SP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp6
Alternative name(s):
Krueppel-like factor 14
Gene namesi
Name:SP6
Synonyms:KLF14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14530. SP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37892.

Polymorphism and mutation databases

BioMutaiSP6.
DMDMi82582258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Transcription factor Sp6PRO_0000047148Add
BLAST

Proteomic databases

MaxQBiQ3SY56.
PaxDbiQ3SY56.
PeptideAtlasiQ3SY56.
PRIDEiQ3SY56.

PTM databases

PhosphoSiteiQ3SY56.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ3SY56.
CleanExiHS_KLF14.
HS_SP6.
GenevisibleiQ3SY56. HS.

Organism-specific databases

HPAiHPA024516.
HPA044469.

Interactioni

Protein-protein interaction databases

BioGridi123233. 8 interactions.
IntActiQ3SY56. 3 interactions.
STRINGi9606.ENSP00000340799.

Structurei

3D structure databases

ProteinModelPortaliQ3SY56.
SMRiQ3SY56. Positions 246-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG102037.
InParanoidiQ3SY56.
KOiK09196.
OMAiTEDGSWW.
OrthoDBiEOG7DC255.
PhylomeDBiQ3SY56.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SY56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAVCGSLG SQHTEAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG
60 70 80 90 100
ELQSLPLGPE VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM
110 120 130 140 150
SHHYESWFRP THPGAEDGSW WDLHPGTSWM DLPHTQGALT SPGHPGALQA
160 170 180 190 200
GLGGYVGDHQ LCAPPPHPHA HHLLPAAGGQ HLLGPPDGAK ALEVAAPESQ
210 220 230 240 250
GLDSSLDGAA RPKGSRRSVP RSSGQTVCRC PNCLEAERLG APCGPDGGKK
260 270 280 290 300
KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE
310 320 330 340 350
LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAGAASGE
360 370
GKAGGAVEPP GGKGKREAEG SVAPSN
Length:376
Mass (Da):39,840
Last modified:October 11, 2005 - v1
Checksum:i1F4355CFB75206E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561V → I.
Corresponds to variant rs34309518 [ dbSNP | Ensembl ].
VAR_052714

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127850 mRNA. Translation: BAG54586.1.
CH471109 Genomic DNA. Translation: EAW94789.1.
BC103951 mRNA. Translation: AAI03952.1.
BC103952 mRNA. Translation: AAI03953.1.
BC103953 mRNA. Translation: AAI03954.1.
BC103954 mRNA. Translation: AAI03955.1.
CCDSiCCDS11520.1.
RefSeqiNP_001245177.1. NM_001258248.1.
NP_954871.1. NM_199262.2.
XP_006722178.1. XM_006722115.2.
UniGeneiHs.253603.

Genome annotation databases

EnsembliENST00000342234; ENSP00000340799; ENSG00000189120.
ENST00000536300; ENSP00000438209; ENSG00000189120.
GeneIDi80320.
KEGGihsa:80320.
UCSCiuc002img.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127850 mRNA. Translation: BAG54586.1.
CH471109 Genomic DNA. Translation: EAW94789.1.
BC103951 mRNA. Translation: AAI03952.1.
BC103952 mRNA. Translation: AAI03953.1.
BC103953 mRNA. Translation: AAI03954.1.
BC103954 mRNA. Translation: AAI03955.1.
CCDSiCCDS11520.1.
RefSeqiNP_001245177.1. NM_001258248.1.
NP_954871.1. NM_199262.2.
XP_006722178.1. XM_006722115.2.
UniGeneiHs.253603.

3D structure databases

ProteinModelPortaliQ3SY56.
SMRiQ3SY56. Positions 246-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123233. 8 interactions.
IntActiQ3SY56. 3 interactions.
STRINGi9606.ENSP00000340799.

PTM databases

PhosphoSiteiQ3SY56.

Polymorphism and mutation databases

BioMutaiSP6.
DMDMi82582258.

Proteomic databases

MaxQBiQ3SY56.
PaxDbiQ3SY56.
PeptideAtlasiQ3SY56.
PRIDEiQ3SY56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342234; ENSP00000340799; ENSG00000189120.
ENST00000536300; ENSP00000438209; ENSG00000189120.
GeneIDi80320.
KEGGihsa:80320.
UCSCiuc002img.3. human.

Organism-specific databases

CTDi80320.
GeneCardsiSP6.
HGNCiHGNC:14530. SP6.
HPAiHPA024516.
HPA044469.
MIMi608613. gene.
neXtProtiNX_Q3SY56.
PharmGKBiPA37892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG102037.
InParanoidiQ3SY56.
KOiK09196.
OMAiTEDGSWW.
OrthoDBiEOG7DC255.
PhylomeDBiQ3SY56.
TreeFamiTF315506.

Miscellaneous databases

GenomeRNAii80320.
NextBioi70835.
PROiQ3SY56.
SOURCEiSearch...

Gene expression databases

BgeeiQ3SY56.
CleanExiHS_KLF14.
HS_SP6.
GenevisibleiQ3SY56. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSP6_HUMAN
AccessioniPrimary (citable) accession number: Q3SY56
Secondary accession number(s): B3KXS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: April 13, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.