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Protein

Keratin-associated protein 13-3

Gene

KRTAP13-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

Enzyme and pathway databases

BioCyciZFISH:G66-31148-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 13-3
Gene namesi
Name:KRTAP13-3
Synonyms:KAP13.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18925. KRTAP13-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000240432.
PharmGKBiPA134901486.

Polymorphism and mutation databases

BioMutaiKRTAP13-3.
DMDMi82592929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852021 – 172Keratin-associated protein 13-3Add BLAST172

Proteomic databases

PaxDbiQ3SY46.
PeptideAtlasiQ3SY46.
PRIDEiQ3SY46.

Expressioni

Gene expression databases

CleanExiHS_KRTAP13-3.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLQ7Z3S95EBI-10241252,EBI-945833

Protein-protein interaction databases

BioGridi130645. 1 interactor.
IntActiQ3SY46. 2 interactors.
STRINGi9606.ENSP00000375109.

Structurei

3D structure databases

ProteinModelPortaliQ3SY46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 55110
Repeati56 – 65210
Repeati66 – 75310
Repeati76 – 85410
Repeati92 – 101510

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 1015 X 10 AA approximate repeatsAdd BLAST56

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IRAP. Eukaryota.
ENOG4110Q16. LUCA.
GeneTreeiENSGT00390000012339.
HOGENOMiHOG000234032.
HOVERGENiHBG052275.
InParanoidiQ3SY46.
OMAiNGFRYLN.
OrthoDBiEOG091G0PYN.
PhylomeDBiQ3SY46.
TreeFamiTF337331.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SY46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNCCSRNF SSCSHGGYLH YPGSSCGSSY PSNLVYSTDL CSPSTCQLGS
60 70 80 90 100
SLYRGCQETC WRPNSCQTLC VESSPCHTSC YYPRTHMLCN SCLTMHVGSR
110 120 130 140 150
GFGSNSCCSL SCGSRSCSSL GCGSNGFRYL NYRIHTSPSQ SYRSRFCHPI
160 170
YFPPRRWFHS SCYQPFCRSG FY
Length:172
Mass (Da):19,236
Last modified:October 11, 2005 - v1
Checksum:i230EA3775278CBF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13C → R in BAE46355 (Ref. 1) Curated1
Sequence conflicti18Y → H in BAE46355 (Ref. 1) Curated1
Sequence conflicti108C → R in BAE46355 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096940 mRNA. Translation: BAE46355.1.
BC103965 mRNA. Translation: AAI03966.1.
CCDSiCCDS13591.1.
RefSeqiNP_853653.1. NM_181622.1.
UniGeneiHs.553687.

Genome annotation databases

EnsembliENST00000390690; ENSP00000375109; ENSG00000240432.
GeneIDi337960.
KEGGihsa:337960.
UCSCiuc002yob.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096940 mRNA. Translation: BAE46355.1.
BC103965 mRNA. Translation: AAI03966.1.
CCDSiCCDS13591.1.
RefSeqiNP_853653.1. NM_181622.1.
UniGeneiHs.553687.

3D structure databases

ProteinModelPortaliQ3SY46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130645. 1 interactor.
IntActiQ3SY46. 2 interactors.
STRINGi9606.ENSP00000375109.

Polymorphism and mutation databases

BioMutaiKRTAP13-3.
DMDMi82592929.

Proteomic databases

PaxDbiQ3SY46.
PeptideAtlasiQ3SY46.
PRIDEiQ3SY46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390690; ENSP00000375109; ENSG00000240432.
GeneIDi337960.
KEGGihsa:337960.
UCSCiuc002yob.2. human.

Organism-specific databases

CTDi337960.
GeneCardsiKRTAP13-3.
HGNCiHGNC:18925. KRTAP13-3.
neXtProtiNX_Q3SY46.
OpenTargetsiENSG00000240432.
PharmGKBiPA134901486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRAP. Eukaryota.
ENOG4110Q16. LUCA.
GeneTreeiENSGT00390000012339.
HOGENOMiHOG000234032.
HOVERGENiHBG052275.
InParanoidiQ3SY46.
OMAiNGFRYLN.
OrthoDBiEOG091G0PYN.
PhylomeDBiQ3SY46.
TreeFamiTF337331.

Enzyme and pathway databases

BioCyciZFISH:G66-31148-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii337960.
PROiQ3SY46.

Gene expression databases

CleanExiHS_KRTAP13-3.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKR133_HUMAN
AccessioniPrimary (citable) accession number: Q3SY46
Secondary accession number(s): Q3LI78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.