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Protein

Solute carrier family 25 member 52

Gene

SLC25A52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.2.12. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 52
Alternative name(s):
Mitochondrial carrier triple repeat protein 2
Gene namesi
Name:SLC25A52
Synonyms:MCART2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23324. SLC25A52.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5118Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei268 – 28922Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25306.

Polymorphism and mutation databases

BioMutaiSLC25A52.
DMDMi296436436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Solute carrier family 25 member 52PRO_0000271790Add
BLAST

Proteomic databases

MaxQBiQ3SY17.
PaxDbiQ3SY17.
PRIDEiQ3SY17.

PTM databases

iPTMnetiQ3SY17.
PhosphoSiteiQ3SY17.

Expressioni

Gene expression databases

BgeeiQ3SY17.
CleanExiHS_MCART2.

Organism-specific databases

HPAiHPA058261.
HPA058273.

Interactioni

Protein-protein interaction databases

BioGridi127058. 1 interaction.
STRINGi9606.ENSP00000462754.

Structurei

3D structure databases

ProteinModelPortaliQ3SY17.
SMRiQ3SY17. Positions 47-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 10881Solcar 1Add
BLAST
Repeati116 – 20085Solcar 2Add
BLAST
Repeati209 – 29688Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
HOVERGENiHBG052423.
InParanoidiQ3SY17.
PhylomeDBiQ3SY17.
TreeFamiTF314192.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SY17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITYP
60 70 80 90 100
IQKVLFRQQL YGIKTRDAVL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG
110 120 130 140 150
LYEDLSCLLR KHVRAPEFAT HGVAAVLAGT AEAIFTPLER VQTLLQNHKH
160 170 180 190 200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH
210 220 230 240 250
LPTATTHSAH LVNDFIGGGL LGAMLGFLCF PINVVKTRLQ SQIGGEFQSF
260 270 280 290
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKFI
Length:297
Mass (Da):33,721
Last modified:May 18, 2010 - v2
Checksum:i8BA8EFEABA74E2FC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti239 – 2391L → I.1 Publication
Corresponds to variant rs3859364 [ dbSNP | Ensembl ].
VAR_060299

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022960 Genomic DNA. No translation available.
BC103999 mRNA. Translation: AAI04000.1.
BC104000 mRNA. Translation: AAI04001.1.
BC104001 mRNA. Translation: AAI04002.1.
RefSeqiNP_001029344.3. NM_001034172.2.
UniGeneiHs.567708.

Genome annotation databases

EnsembliENST00000579441; ENSP00000462754; ENSG00000141437.
GeneIDi147407.
KEGGihsa:147407.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022960 Genomic DNA. No translation available.
BC103999 mRNA. Translation: AAI04000.1.
BC104000 mRNA. Translation: AAI04001.1.
BC104001 mRNA. Translation: AAI04002.1.
RefSeqiNP_001029344.3. NM_001034172.2.
UniGeneiHs.567708.

3D structure databases

ProteinModelPortaliQ3SY17.
SMRiQ3SY17. Positions 47-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127058. 1 interaction.
STRINGi9606.ENSP00000462754.

Protein family/group databases

TCDBi2.A.29.2.12. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ3SY17.
PhosphoSiteiQ3SY17.

Polymorphism and mutation databases

BioMutaiSLC25A52.
DMDMi296436436.

Proteomic databases

MaxQBiQ3SY17.
PaxDbiQ3SY17.
PRIDEiQ3SY17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000579441; ENSP00000462754; ENSG00000141437.
GeneIDi147407.
KEGGihsa:147407.

Organism-specific databases

CTDi147407.
GeneCardsiSLC25A52.
H-InvDBHIX0059795.
HGNCiHGNC:23324. SLC25A52.
HPAiHPA058261.
HPA058273.
MIMi616153. gene.
neXtProtiNX_Q3SY17.
PharmGKBiPA25306.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
HOVERGENiHBG052423.
InParanoidiQ3SY17.
PhylomeDBiQ3SY17.
TreeFamiTF314192.

Miscellaneous databases

GenomeRNAii147407.
PROiQ3SY17.
SOURCEiSearch...

Gene expression databases

BgeeiQ3SY17.
CleanExiHS_MCART2.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-239.

Entry informationi

Entry nameiS2552_HUMAN
AccessioniPrimary (citable) accession number: Q3SY17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.