Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Testis-specific protein 10-interacting protein

Gene

TSGA10IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific protein 10-interacting protein
Alternative name(s):
Tsga10-interacting protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26555. TSGA10IP.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983361.

Polymorphism and mutation databases

BioMutaiTSGA10IP.
DMDMi121942943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Testis-specific protein 10-interacting proteinPRO_0000331421Add
BLAST

Proteomic databases

PRIDEiQ3SY00.

PTM databases

PhosphoSiteiQ3SY00.

Expressioni

Gene expression databases

CleanExiHS_TSGA10IP.
ExpressionAtlasiQ3SY00. baseline.
GenevestigatoriQ3SY00.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC57Q2TAC23EBI-10241197,EBI-2808286
CEP70Q8NHQ13EBI-10241197,EBI-739624
KRT40Q6A1623EBI-10241197,EBI-10171697
MTUS2Q5JR593EBI-10241197,EBI-742948
TRIM27P143733EBI-10241197,EBI-719493

Protein-protein interaction databases

BioGridi129021. 16 interactions.
IntActiQ3SY00. 5 interactions.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili379 – 46486Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG28878.
GeneTreeiENSGT00390000008351.
HOGENOMiHOG000170724.
HOVERGENiHBG096788.
InParanoidiQ3SY00.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3SY00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG
60 70 80 90 100
CLGSGDGVPN QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL
110 120 130 140 150
PRKPSFPFQW AWESIATDVR AVLQPSSPTP GHQALPMPSS FSQRQSRRKS
160 170 180 190 200
TANLPEAHGC CWKTEAQNLK ARQQLGAWGG VSIPTGKGEL GSEPPSGLQL
210 220 230 240 250
PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR GSISEEEQFS
260 270 280 290 300
EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN
310 320 330 340 350
NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGPQKLP WKTLRAAFQA
360 370 380 390 400
SKRNGKAYAS GYDETFVSAN LPNRTFHKRQ EATRSLLQAW ERQRQEERQQ
410 420 430 440 450
AELRRARTQH VQRQVAHCLA AYAPRGSRGP GAAQRKLEEL RRQERQRFAE
460 470 480 490 500
YQAELQGIQH RVQARPFLFQ QAMQANARLT VTRRFSQVLS ALGLDEEQLL
510 520 530 540 550
SEAGKVDREG TPRKPRSHRS MGVRMEHSPQ RPPRTEPTGS QPDRHYNPSL

DPECSP
Length:556
Mass (Da):62,381
Last modified:July 9, 2014 - v2
Checksum:iA676754C093FDA61
GO
Isoform 2 (identifier: Q3SY00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-404: PQKLPWKTLR...QEERQQAELR → SHQEPAAGLG...AEAPGATALC
     405-556: Missing.

Note: No experimental confirmation available.

Show »
Length:403
Mass (Da):42,887
Checksum:i33CEDFE052DA823A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671S → P in BAB71488 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti210 – 2101A → V.
Corresponds to variant rs565921 [ dbSNP | Ensembl ].
VAR_042855
Natural varianti237 – 2371R → S.
Corresponds to variant rs7927388 [ dbSNP | Ensembl ].
VAR_042856
Natural varianti292 – 2921S → N.
Corresponds to variant rs7927826 [ dbSNP | Ensembl ].
VAR_042857
Natural varianti305 – 3051R → P.
Corresponds to variant rs7927841 [ dbSNP | Ensembl ].
VAR_042858
Natural varianti521 – 5211M → V.1 Publication
Corresponds to variant rs491973 [ dbSNP | Ensembl ].
VAR_042859

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei336 – 40469PQKLP…QAELR → SHQEPAAGLGAAAAGGAAAG RAAAGPDTACTAAGGPLPGS LRTQREPGPWGGPAQAGGAE APGATALC in isoform 2. 1 PublicationVSP_033196Add
BLAST
Alternative sequencei405 – 556152Missing in isoform 2. 1 PublicationVSP_033197Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057442 mRNA. Translation: BAB71488.1.
AP006287 Genomic DNA. No translation available.
BC104022 mRNA. Translation: AAI04023.1.
BC104023 mRNA. Translation: AAI04024.1.
CCDSiCCDS66138.1. [Q3SY00-1]
RefSeqiNP_689975.2. NM_152762.2. [Q3SY00-1]
UniGeneiHs.350671.

Genome annotation databases

EnsembliENST00000532620; ENSP00000484252; ENSG00000175513. [Q3SY00-1]
ENST00000608857; ENSP00000477317; ENSG00000175513. [Q3SY00-2]
GeneIDi254187.
KEGGihsa:254187.
UCSCiuc001ogk.1. human. [Q3SY00-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057442 mRNA. Translation: BAB71488.1.
AP006287 Genomic DNA. No translation available.
BC104022 mRNA. Translation: AAI04023.1.
BC104023 mRNA. Translation: AAI04024.1.
CCDSiCCDS66138.1. [Q3SY00-1]
RefSeqiNP_689975.2. NM_152762.2. [Q3SY00-1]
UniGeneiHs.350671.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129021. 16 interactions.
IntActiQ3SY00. 5 interactions.

PTM databases

PhosphoSiteiQ3SY00.

Polymorphism and mutation databases

BioMutaiTSGA10IP.
DMDMi121942943.

Proteomic databases

PRIDEiQ3SY00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532620; ENSP00000484252; ENSG00000175513. [Q3SY00-1]
ENST00000608857; ENSP00000477317; ENSG00000175513. [Q3SY00-2]
GeneIDi254187.
KEGGihsa:254187.
UCSCiuc001ogk.1. human. [Q3SY00-1]

Organism-specific databases

CTDi254187.
GeneCardsiGC11P065713.
HGNCiHGNC:26555. TSGA10IP.
neXtProtiNX_Q3SY00.
PharmGKBiPA134983361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28878.
GeneTreeiENSGT00390000008351.
HOGENOMiHOG000170724.
HOVERGENiHBG096788.
InParanoidiQ3SY00.

Miscellaneous databases

GenomeRNAii254187.
NextBioi92283.
PROiQ3SY00.

Gene expression databases

CleanExiHS_TSGA10IP.
ExpressionAtlasiQ3SY00. baseline.
GenevestigatoriQ3SY00.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-521.

Entry informationi

Entry nameiT10IP_HUMAN
AccessioniPrimary (citable) accession number: Q3SY00
Secondary accession number(s): Q3SXZ9, Q3SY01, Q96M26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 9, 2014
Last modified: May 27, 2015
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.