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Q3SY00 (T10IP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-specific protein 10-interacting protein
Alternative name(s):
Tsga10-interacting protein
Gene names
Name:TSGA10IP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3SY00-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3SY00-2)

The sequence of this isoform differs from the canonical sequence as follows:
     336-404: PQKLPWKTLR...QEERQQAELR → SHQEPAAGLG...AEAPGATALC
     405-556: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Testis-specific protein 10-interacting protein
PRO_0000331421

Regions

Coiled coil379 – 46486 Potential

Natural variations

Alternative sequence336 – 40469PQKLP…QAELR → SHQEPAAGLGAAAAGGAAAG RAAAGPDTACTAAGGPLPGS LRTQREPGPWGGPAQAGGAE APGATALC in isoform 2.
VSP_033196
Alternative sequence405 – 556152Missing in isoform 2.
VSP_033197
Natural variant2101A → V.
Corresponds to variant rs565921 [ dbSNP | Ensembl ].
VAR_042855
Natural variant2371R → S.
Corresponds to variant rs7927388 [ dbSNP | Ensembl ].
VAR_042856
Natural variant2921S → N.
Corresponds to variant rs7927826 [ dbSNP | Ensembl ].
VAR_042857
Natural variant3051R → P.
Corresponds to variant rs7927841 [ dbSNP | Ensembl ].
VAR_042858
Natural variant5211V → M. Ref.1
Corresponds to variant rs491973 [ dbSNP | Ensembl ].
VAR_042859

Experimental info

Sequence conflict671S → P in BAB71488. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: A67675591D6E8A61

FASTA55662,349
        10         20         30         40         50         60 
MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG CLGSGDGVPN 

        70         80         90        100        110        120 
QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL PRKPSFPFQW AWESIATDVR 

       130        140        150        160        170        180 
AVLQPSSPTP GHQALPMPSS FSQRQSRRKS TANLPEAHGC CWKTEAQNLK ARQQLGAWGG 

       190        200        210        220        230        240 
VSIPTGKGEL GSEPPSGLQL PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR 

       250        260        270        280        290        300 
GSISEEEQFS EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN 

       310        320        330        340        350        360 
NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGPQKLP WKTLRAAFQA SKRNGKAYAS 

       370        380        390        400        410        420 
GYDETFVSAN LPNRTFHKRQ EATRSLLQAW ERQRQEERQQ AELRRARTQH VQRQVAHCLA 

       430        440        450        460        470        480 
AYAPRGSRGP GAAQRKLEEL RRQERQRFAE YQAELQGIQH RVQARPFLFQ QAMQANARLT 

       490        500        510        520        530        540 
VTRRFSQVLS ALGLDEEQLL SEAGKVDREG TPRKPRSHRS VGVRMEHSPQ RPPRTEPTGS 

       550 
QPDRHYNPSL DPECSP 

« Hide

Isoform 2 [UniParc].

Checksum: 33CEDFE052DA823A
Show »

FASTA40342,887

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-521.
Tissue: Testis.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057442 mRNA. Translation: BAB71488.1.
AP006287 Genomic DNA. No translation available.
BC104022 mRNA. Translation: AAI04023.1.
BC104023 mRNA. Translation: AAI04024.1.
RefSeqNP_689975.2. NM_152762.2.
UniGeneHs.350671.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3SY00.

Polymorphism databases

DMDM121942943.

Proteomic databases

PRIDEQ3SY00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID254187.
KEGGhsa:254187.
UCSCuc001ogk.1. human. [Q3SY00-1]

Organism-specific databases

CTD254187.
GeneCardsGC11P065713.
HGNCHGNC:26555. TSGA10IP.
neXtProtNX_Q3SY00.
PharmGKBPA134983361.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28878.
HOGENOMHOG000170724.
HOVERGENHBG096788.
InParanoidQ3SY00.
PhylomeDBQ3SY00.

Gene expression databases

CleanExHS_TSGA10IP.
GenevestigatorQ3SY00.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi254187.
NextBio92283.
PROQ3SY00.

Entry information

Entry nameT10IP_HUMAN
AccessionPrimary (citable) accession number: Q3SY00
Secondary accession number(s): Q3SXZ9, Q3SY01, Q96M26
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM