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Q3SY00

- T10IP_HUMAN

UniProt

Q3SY00 - T10IP_HUMAN

Protein

Testis-specific protein 10-interacting protein

Gene

TSGA10IP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (09 Jul 2014)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific protein 10-interacting protein
    Alternative name(s):
    Tsga10-interacting protein
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:26555. TSGA10IP.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134983361.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Testis-specific protein 10-interacting proteinPRO_0000331421Add
    BLAST

    Proteomic databases

    MaxQBiQ3SY00.
    PRIDEiQ3SY00.

    PTM databases

    PhosphoSiteiQ3SY00.

    Expressioni

    Gene expression databases

    CleanExiHS_TSGA10IP.
    GenevestigatoriQ3SY00.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili379 – 46486Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG28878.
    HOGENOMiHOG000170724.
    HOVERGENiHBG096788.
    InParanoidiQ3SY00.
    PhylomeDBiQ3SY00.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3SY00-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG    50
    CLGSGDGVPN QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL 100
    PRKPSFPFQW AWESIATDVR AVLQPSSPTP GHQALPMPSS FSQRQSRRKS 150
    TANLPEAHGC CWKTEAQNLK ARQQLGAWGG VSIPTGKGEL GSEPPSGLQL 200
    PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR GSISEEEQFS 250
    EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN 300
    NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGPQKLP WKTLRAAFQA 350
    SKRNGKAYAS GYDETFVSAN LPNRTFHKRQ EATRSLLQAW ERQRQEERQQ 400
    AELRRARTQH VQRQVAHCLA AYAPRGSRGP GAAQRKLEEL RRQERQRFAE 450
    YQAELQGIQH RVQARPFLFQ QAMQANARLT VTRRFSQVLS ALGLDEEQLL 500
    SEAGKVDREG TPRKPRSHRS MGVRMEHSPQ RPPRTEPTGS QPDRHYNPSL 550
    DPECSP 556
    Length:556
    Mass (Da):62,381
    Last modified:July 9, 2014 - v2
    Checksum:iA676754C093FDA61
    GO
    Isoform 2 (identifier: Q3SY00-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         336-404: PQKLPWKTLR...QEERQQAELR → SHQEPAAGLG...AEAPGATALC
         405-556: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:403
    Mass (Da):42,887
    Checksum:i33CEDFE052DA823A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671S → P in BAB71488. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti210 – 2101A → V.
    Corresponds to variant rs565921 [ dbSNP | Ensembl ].
    VAR_042855
    Natural varianti237 – 2371R → S.
    Corresponds to variant rs7927388 [ dbSNP | Ensembl ].
    VAR_042856
    Natural varianti292 – 2921S → N.
    Corresponds to variant rs7927826 [ dbSNP | Ensembl ].
    VAR_042857
    Natural varianti305 – 3051R → P.
    Corresponds to variant rs7927841 [ dbSNP | Ensembl ].
    VAR_042858
    Natural varianti521 – 5211M → V.1 Publication
    Corresponds to variant rs491973 [ dbSNP | Ensembl ].
    VAR_042859

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei336 – 40469PQKLP…QAELR → SHQEPAAGLGAAAAGGAAAG RAAAGPDTACTAAGGPLPGS LRTQREPGPWGGPAQAGGAE APGATALC in isoform 2. 1 PublicationVSP_033196Add
    BLAST
    Alternative sequencei405 – 556152Missing in isoform 2. 1 PublicationVSP_033197Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057442 mRNA. Translation: BAB71488.1.
    AP006287 Genomic DNA. No translation available.
    BC104022 mRNA. Translation: AAI04023.1.
    BC104023 mRNA. Translation: AAI04024.1.
    CCDSiCCDS66138.1. [Q3SY00-1]
    RefSeqiNP_689975.2. NM_152762.2.
    UniGeneiHs.350671.

    Genome annotation databases

    GeneIDi254187.
    KEGGihsa:254187.
    UCSCiuc001ogk.1. human. [Q3SY00-1]

    Polymorphism databases

    DMDMi121942943.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057442 mRNA. Translation: BAB71488.1 .
    AP006287 Genomic DNA. No translation available.
    BC104022 mRNA. Translation: AAI04023.1 .
    BC104023 mRNA. Translation: AAI04024.1 .
    CCDSi CCDS66138.1. [Q3SY00-1 ]
    RefSeqi NP_689975.2. NM_152762.2.
    UniGenei Hs.350671.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3SY00.

    Polymorphism databases

    DMDMi 121942943.

    Proteomic databases

    MaxQBi Q3SY00.
    PRIDEi Q3SY00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 254187.
    KEGGi hsa:254187.
    UCSCi uc001ogk.1. human. [Q3SY00-1 ]

    Organism-specific databases

    CTDi 254187.
    GeneCardsi GC11P065713.
    HGNCi HGNC:26555. TSGA10IP.
    neXtProti NX_Q3SY00.
    PharmGKBi PA134983361.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28878.
    HOGENOMi HOG000170724.
    HOVERGENi HBG096788.
    InParanoidi Q3SY00.
    PhylomeDBi Q3SY00.

    Miscellaneous databases

    GenomeRNAii 254187.
    NextBioi 92283.
    PROi Q3SY00.

    Gene expression databases

    CleanExi HS_TSGA10IP.
    Genevestigatori Q3SY00.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-521.

    Entry informationi

    Entry nameiT10IP_HUMAN
    AccessioniPrimary (citable) accession number: Q3SY00
    Secondary accession number(s): Q3SXZ9, Q3SY01, Q96M26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 9, 2014
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3