Q3SY00 (T10IP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testis-specific protein 10-interacting protein

Alternative name(s):
Tsga10-interacting protein

Gene names

Name:

TSGA10IP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3SY00-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3SY00-2)

The sequence of this isoform differs from the canonical sequence as follows:
     336-404: PQKLPWKTLR...QEERQQAELR → SHQEPAAGLG...AEAPGATALC
     405-556: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Testis-specific protein 10-interacting protein		PRO_0000331421
Regions
	Coiled coil	379 – 464	86	Potential
Natural variations
	Alternative sequence	336 – 404	69	PQKLP…QAELR → SHQEPAAGLGAAAAGGAAAG RAAAGPDTACTAAGGPLPGS LRTQREPGPWGGPAQAGGAE APGATALC in isoform 2.		VSP_033196
	Alternative sequence	405 – 556	152	Missing in isoform 2.		VSP_033197
	Natural variant	210	1	A → V. Corresponds to variant rs565921 [ dbSNP | Ensembl ].		VAR_042855
	Natural variant	237	1	R → S. Corresponds to variant rs7927388 [ dbSNP | Ensembl ].		VAR_042856
	Natural variant	292	1	S → N. Corresponds to variant rs7927826 [ dbSNP | Ensembl ].		VAR_042857
	Natural variant	305	1	R → P. Corresponds to variant rs7927841 [ dbSNP | Ensembl ].		VAR_042858
	Natural variant	521	1	V → M. Ref.1 Corresponds to variant rs491973 [ dbSNP | Ensembl ].		VAR_042859
Experimental info
	Sequence conflict	67	1	S → P in BAB71488. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: A67675591D6E8A61	FASTA	556	62,349
	10 20 30 40 50 60 MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG CLGSGDGVPN 70 80 90 100 110 120 QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL PRKPSFPFQW AWESIATDVR 130 140 150 160 170 180 AVLQPSSPTP GHQALPMPSS FSQRQSRRKS TANLPEAHGC CWKTEAQNLK ARQQLGAWGG 190 200 210 220 230 240 VSIPTGKGEL GSEPPSGLQL PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR 250 260 270 280 290 300 GSISEEEQFS EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN 310 320 330 340 350 360 NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGPQKLP WKTLRAAFQA SKRNGKAYAS 370 380 390 400 410 420 GYDETFVSAN LPNRTFHKRQ EATRSLLQAW ERQRQEERQQ AELRRARTQH VQRQVAHCLA 430 440 450 460 470 480 AYAPRGSRGP GAAQRKLEEL RRQERQRFAE YQAELQGIQH RVQARPFLFQ QAMQANARLT 490 500 510 520 530 540 VTRRFSQVLS ALGLDEEQLL SEAGKVDREG TPRKPRSHRS VGVRMEHSPQ RPPRTEPTGS 550 QPDRHYNPSL DPECSP
	Isoform 2 [UniParc]. Checksum: 33CEDFE052DA823A	FASTA	403	42,887
	10 20 30 40 50 60 MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG CLGSGDGVPN 70 80 90 100 110 120 QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL PRKPSFPFQW AWESIATDVR 130 140 150 160 170 180 AVLQPSSPTP GHQALPMPSS FSQRQSRRKS TANLPEAHGC CWKTEAQNLK ARQQLGAWGG 190 200 210 220 230 240 VSIPTGKGEL GSEPPSGLQL PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR 250 260 270 280 290 300 GSISEEEQFS EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN 310 320 330 340 350 360 NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGSHQEP AAGLGAAAAG GAAAGRAAAG 370 380 390 400 PDTACTAAGG PLPGSLRTQR EPGPWGGPAQ AGGAEAPGAT ALC

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-521. Tissue: Testis.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057442 mRNA. Translation: BAB71488.1. AP006287 Genomic DNA. No translation available. BC104022 mRNA. Translation: AAI04023.1. BC104023 mRNA. Translation: AAI04024.1.
IPI	IPI00065223. IPI00890830.
RefSeq	NP_689975.2. NM_152762.2.
UniGene	Hs.350671.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q3SY00.
Polymorphism databases
DMDM	121942943.
Proteomic databases
PRIDE	Q3SY00.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	254187.
KEGG	hsa:254187.
UCSC	uc001ogk.1. human.
Organism-specific databases
CTD	254187.
GeneCards	GC11P065713.
HGNC	HGNC:26555. TSGA10IP.
neXtProt	NX_Q3SY00.
PharmGKB	PA134983361.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG28878.
HOGENOM	HOG000170724.
HOVERGEN	HBG096788.
InParanoid	Q3SY00.
OrthoDB	EOG473PRJ.
Gene expression databases
CleanEx	HS_TSGA10IP.
Genevestigator	Q3SY00.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	254187.
NextBio	92283.

Entry information

Entry name

T10IP_HUMAN

Accession

Primary (citable) accession number: Q3SY00
Secondary accession number(s): Q3SXZ9, Q3SY01, Q96M26

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 11, 2005
Last modified:	March 6, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.