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Protein

Zinc finger protein 718

Gene

ZNF718

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 718
Gene namesi
Name:ZNF718
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26889. ZNF718.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485682.

Polymorphism and mutation databases

BioMutaiZNF718.
DMDMi94730683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Zinc finger protein 718PRO_0000233286Add
BLAST

Proteomic databases

EPDiQ3SXZ3.
PeptideAtlasiQ3SXZ3.
PRIDEiQ3SXZ3.

PTM databases

iPTMnetiQ3SXZ3.
PhosphoSiteiQ3SXZ3.

Expressioni

Gene expression databases

CleanExiHS_ZNF718.

Structurei

3D structure databases

ProteinModelPortaliQ3SXZ3.
SMRiQ3SXZ3. Positions 4-44, 155-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri339 – 36123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri367 – 38923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 41723C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiQ3SXZ3.
KOiK09228.
PhylomeDBiQ3SXZ3.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3SXZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLTFKDVA IEFSPEEWKC LDISQQNLYR DVMLENYRNL VSLGVTISNP
60 70 80 90 100
DLVTSLEQRK EPYNLKIHET AARPPAVCSH FTQNLWTVQG IEDSFHKLIP
110 120 130 140 150
KGHEKRGHEN LRKTCKSINE CKVQKGGYNR INQCLLTTQK KTIQSNICVK
160 170 180 190 200
VFHKFSNSNK DKIRYTGDKT FKCKECGKSF HVLSRLTQHK RIHTGENPYT
210 220 230 240 250
CEECGKAFNW SSILTKHKRI HAREKFYKCE ECGKGFTRSS HLTKHKRIHT
260 270 280 290 300
GEKPYICEKC GKAFNQSSTL NLHKRIHSAQ KYYKCEECGK AFKWSSSLNE
310 320 330 340 350
HKRIHAGEKP FSCEECGNVF TTSSDFAKHK RIHTGEKPYK CEECGKSFNR
360 370 380 390 400
STTLTTHKRI HTGEKPYTCE ECGKAFNWSS TLNVHKRIHS GKNPYKCEDC
410 420 430 440 450
GKAFKVFANL HNRKKIHTGE KPYICKQCGK AFKQSSHLNK HKKIHTVDKP
460 470
YKCKECGKAF KQYSNLPQHK RTHTGGKF
Length:478
Mass (Da):55,404
Last modified:October 11, 2005 - v1
Checksum:iE80DFF2FBE2371D5
GO
Isoform 2 (identifier: Q3SXZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:446
Mass (Da):51,561
Checksum:i47F57F7E3A42479E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231I → T in AAI04028 (PubMed:15489334).Curated
Sequence conflicti46 – 461T → S in AAI04028 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401K → N.
Corresponds to variant rs9684215 [ dbSNP | Ensembl ].
VAR_059933
Natural varianti140 – 1401K → R.
Corresponds to variant rs9684214 [ dbSNP | Ensembl ].
VAR_059934
Natural varianti297 – 2971S → Y.
Corresponds to variant rs7677201 [ dbSNP | Ensembl ].
VAR_059935
Natural varianti413 – 4131R → H.1 Publication
Corresponds to variant rs7440274 [ dbSNP | Ensembl ].
VAR_059936

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_018110Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104026 mRNA. Translation: AAI04027.1.
BC104027 mRNA. Translation: AAI04028.1.
BC104028 mRNA. Translation: AAI04029.1.
BC104029 mRNA. Translation: AAI04030.1.
CCDSiCCDS75078.1. [Q3SXZ3-1]
CCDS75079.1. [Q3SXZ3-2]
RefSeqiNP_001034216.2. NM_001039127.5.
NP_001276859.1. NM_001289930.1.
NP_001276860.1. NM_001289931.1.
UniGeneiHs.636638.
Hs.724954.
Hs.745062.
Hs.745417.

Genome annotation databases

GeneIDi255403.
KEGGihsa:255403.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104026 mRNA. Translation: AAI04027.1.
BC104027 mRNA. Translation: AAI04028.1.
BC104028 mRNA. Translation: AAI04029.1.
BC104029 mRNA. Translation: AAI04030.1.
CCDSiCCDS75078.1. [Q3SXZ3-1]
CCDS75079.1. [Q3SXZ3-2]
RefSeqiNP_001034216.2. NM_001039127.5.
NP_001276859.1. NM_001289930.1.
NP_001276860.1. NM_001289931.1.
UniGeneiHs.636638.
Hs.724954.
Hs.745062.
Hs.745417.

3D structure databases

ProteinModelPortaliQ3SXZ3.
SMRiQ3SXZ3. Positions 4-44, 155-477.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3SXZ3.
PhosphoSiteiQ3SXZ3.

Polymorphism and mutation databases

BioMutaiZNF718.
DMDMi94730683.

Proteomic databases

EPDiQ3SXZ3.
PeptideAtlasiQ3SXZ3.
PRIDEiQ3SXZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi255403.
KEGGihsa:255403.

Organism-specific databases

CTDi255403.
GeneCardsiZNF718.
HGNCiHGNC:26889. ZNF718.
neXtProtiNX_Q3SXZ3.
PharmGKBiPA143485682.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiQ3SXZ3.
KOiK09228.
PhylomeDBiQ3SXZ3.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF718. human.
GenomeRNAii255403.
PROiQ3SXZ3.

Gene expression databases

CleanExiHS_ZNF718.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN718_HUMAN
AccessioniPrimary (citable) accession number: Q3SXZ3
Secondary accession number(s): Q3SXZ4, Q3SXZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.