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Protein

Zinc finger protein 718

Gene

ZNF718

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 718
Gene namesi
Name:ZNF718
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000250312.6
HGNCiHGNC:26889 ZNF718
neXtProtiNX_Q3SXZ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi255403
OpenTargetsiENSG00000250312
PharmGKBiPA143485682

Polymorphism and mutation databases

BioMutaiZNF718
DMDMi94730683

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332861 – 478Zinc finger protein 718Add BLAST478

Proteomic databases

EPDiQ3SXZ3
PeptideAtlasiQ3SXZ3
PRIDEiQ3SXZ3

PTM databases

iPTMnetiQ3SXZ3
PhosphoSitePlusiQ3SXZ3

Expressioni

Gene expression databases

BgeeiENSG00000250312
CleanExiHS_ZNF718

Structurei

3D structure databases

ProteinModelPortaliQ3SXZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00910000144042
HOVERGENiHBG018163
InParanoidiQ3SXZ3
KOiK09228
OMAiHEKRGHE
OrthoDBiEOG091G02KC
PhylomeDBiQ3SXZ3

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3SXZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLTFKDVA IEFSPEEWKC LDTSQQNLYR DVMLENYRNL VSLGVSISNP
60 70 80 90 100
DLVTSLEQRK EPYNLKIHET AARPPAVCSH FTQNLWTVQG IEDSFHKLIP
110 120 130 140 150
KGHEKRGHEN LRKTCKSINE CKVQKGGYNR INQCLLTTQK KTIQSNICVK
160 170 180 190 200
VFHKFSNSNK DKIRYTGDKT FKCKECGKSF HVLSRLTQHK RIHTGENPYT
210 220 230 240 250
CEECGKAFNW SSILTKHKRI HAREKFYKCE ECGKGFTRSS HLTKHKRIHT
260 270 280 290 300
GEKPYICEKC GKAFNQSSTL NLHKRIHSAQ KYYKCEECGK AFKWSSSLNE
310 320 330 340 350
HKRIHAGEKP FSCEECGNVF TTSSDFAKHK RIHTGEKPYK CEECGKSFNR
360 370 380 390 400
STTLTTHKRI HTGEKPYTCE ECGKAFNWSS TLNVHKRIHS GKNPYKCEDC
410 420 430 440 450
GKAFKVFANL HNHKKIHTGE KPYICKQCGK AFKQSSHLNK HKKIHTVDKP
460 470
YKCKECGKAF KQYSNLPQHK RTHTGGKF
Length:478
Mass (Da):55,359
Last modified:March 28, 2018 - v2
Checksum:i8362FA9A3A982FFD
GO
Isoform 2 (identifier: Q3SXZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:446
Mass (Da):51,528
Checksum:i36A78A02B03AE38C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → I in AAI04030 (PubMed:15489334).Curated1
Sequence conflicti46S → T in AAI04027 (PubMed:15489334).Curated1
Sequence conflicti46S → T in AAI04029 (PubMed:15489334).Curated1
Sequence conflicti46S → T in AAI04030 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059933140K → N. Corresponds to variant dbSNP:rs9684215Ensembl.1
Natural variantiVAR_059934140K → R. Corresponds to variant dbSNP:rs9684214Ensembl.1
Natural variantiVAR_059935297S → Y. Corresponds to variant dbSNP:rs7677201Ensembl.1
Natural variantiVAR_059936413H → R1 PublicationCorresponds to variant dbSNP:rs7440274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0181101 – 32Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC253576 Genomic DNA No translation available.
BC104026 mRNA Translation: AAI04027.1
BC104027 mRNA Translation: AAI04028.1
BC104028 mRNA Translation: AAI04029.1
BC104029 mRNA Translation: AAI04030.1
BC154406 mRNA Translation: AAI54407.1
CCDSiCCDS75078.1 [Q3SXZ3-1]
CCDS75079.1 [Q3SXZ3-2]
RefSeqiNP_001034216.2, NM_001039127.5 [Q3SXZ3-1]
NP_001276859.1, NM_001289930.1 [Q3SXZ3-2]
NP_001276860.1, NM_001289931.1 [Q3SXZ3-2]
XP_016863468.1, XM_017007979.1 [Q3SXZ3-2]
XP_016863469.1, XM_017007980.1 [Q3SXZ3-2]
UniGeneiHs.636638
Hs.724954
Hs.745062
Hs.745417

Genome annotation databases

EnsembliENST00000510175; ENSP00000480556; ENSG00000250312 [Q3SXZ3-1]
ENST00000609714; ENSP00000476435; ENSG00000250312 [Q3SXZ3-2]
GeneIDi255403
KEGGihsa:255403
UCSCiuc032tae.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN718_HUMAN
AccessioniPrimary (citable) accession number: Q3SXZ3
Secondary accession number(s): A0A075B7G5
, A8WFQ3, Q3SXZ4, Q3SXZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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