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Protein

Protein shisa-like-1

Gene

SHISAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-like-1Imported
Gene namesi
Name:SHISAL1Imported
Synonyms:KIAA1644
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000138944.7.
HGNCiHGNC:29335. SHISAL1.
neXtProtiNX_Q3SXP7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 97ExtracellularSequence analysisAdd BLAST72
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 199CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi85352.
OpenTargetsiENSG00000138944.
PharmGKBiPA164721896.

Polymorphism and mutation databases

BioMutaiKIAA1644.
DMDMi172044643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000031895126 – 199Protein shisa-like-1Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3SXP7.
PRIDEiQ3SXP7.

Expressioni

Gene expression databases

BgeeiENSG00000138944.
GenevisibleiQ3SXP7. HS.

Organism-specific databases

HPAiHPA051178.

Interactioni

Protein-protein interaction databases

BioGridi124484. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ3SXP7.
SMRiQ3SXP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJIJ. Eukaryota.
ENOG410Y76U. LUCA.
GeneTreeiENSGT00390000006791.
HOGENOMiHOG000170254.
HOVERGENiHBG108041.
InParanoidiQ3SXP7.
OMAiHYRVCEP.
OrthoDBiEOG091G0NP0.
PhylomeDBiQ3SXP7.
TreeFamiTF331539.

Family and domain databases

InterProiView protein in InterPro
IPR026910. Shisa.
PANTHERiPTHR31395. PTHR31395. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SXP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSCGQQSLN VLAVLFSLLF SAVLSAHFRV CEPYTDHKGR YHFGFHCPRL
60 70 80 90 100
SDNKTFILCC HHNNTVFKYC CNETEFQAVM QANLTASSEG YMHNNYTALL
110 120 130 140 150
GVWIYGFFVL MLLVLDLLYY SAMNYDICKV YLARWGIQGR WMKQDPRRWG
160 170 180 190
NPARAPRPGQ RAPQPQPPPG PLPQAPQAVH TLRGDAHSPP LMTFQSSSA
Length:199
Mass (Da):22,573
Last modified:February 26, 2008 - v2
Checksum:i55C8E5B55D3B60F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197S → L in AAI04185 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022339 Genomic DNA. No translation available.
AL591914 Genomic DNA. No translation available.
BC104183 mRNA. Translation: AAI04184.1.
BC104184 mRNA. Translation: AAI04185.1.
AB051431 mRNA. Translation: BAB33314.1.
CCDSiCCDS43025.1.
RefSeqiNP_001092764.1. NM_001099294.1.
XP_005261847.1. XM_005261790.3.
UniGeneiHs.6829.

Genome annotation databases

EnsembliENST00000381176; ENSP00000370568; ENSG00000138944.
GeneIDi85352.
KEGGihsa:85352.
UCSCiuc003bet.3. human.

Similar proteinsi

Entry informationi

Entry nameiSHSL1_HUMAN
AccessioniPrimary (citable) accession number: Q3SXP7
Secondary accession number(s): A6NHP0
, A9Z1Z0, Q3SXP8, Q5JZ71, Q9BYB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome