Q3SXM0 (DC4L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DDB1- and CUL4-associated factor 4-like protein 1

Alternative name(s):
WD repeat-containing protein 21B

Gene names

Name:	DCAF4L1
Synonyms:	WDR21B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 2 WD repeats.
Sequence caution	The sequence AAH35027.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	DDB1- and CUL4-associated factor 4-like protein 1		PRO_0000288902
Regions
	Repeat	268 – 307	40	WD 1
	Repeat	312 – 351	40	WD 2
Experimental info
	Sequence conflict	43	1	S → Y in AAH35027. Ref.3
	Sequence conflict	195	1	R → W in AAH52943. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q3SXM0 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: FBD7EC84C61D88A2	FASTA	396	44,264
	10 20 30 40 50 60 MEAERLRLLE EEAKLKKVAR MGFNASSMLR KSQLGFLNVT SYSRLANELR VSCMERKKVQ 70 80 90 100 110 120 IRSLDPSSLA SDRFNFILAS TNSDQLFVVN QVEVEGSKYG IISLRTLKIP SFHVYVLRNL 130 140 150 160 170 180 YVPNRKVKSL CWASLNQLDS HVLLCFEGIT DAPSCAVLLP ASRFLSVHTR VNQPGMLCSF 190 200 210 220 230 240 QIPEAWSCAW SLNTRAYHCF SAGLSQQVLL TSVATGHQQS FDTSSDVLAQ QFASTAPLLF 250 260 270 280 290 300 NGCRSGEIFA IDLRCRNRGK GWRATRLFHD SAVTSVQILQ EEQCLMASDM TGKIKLWDLR 310 320 330 340 350 360 ATKCVRQYEG HVNESAYLPL HVHEEEGIVV AVGQDCYTRI WSLHDAHLLR TIPSPYSASE 370 380 390 DDIPSVAFAS RLGGIRGAAP GLLMAVRQDL YCFPFS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-396. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122914 mRNA. Translation: BAG53795.1. CH471069 Genomic DNA. Translation: EAW92995.1. BC035027 mRNA. Translation: AAH35027.1. Different initiation. BC052943 mRNA. Translation: AAH52943.1. BC104224 mRNA. Translation: AAI04225.1. BC104225 mRNA. Translation: AAI04226.1. AL122070 mRNA. Translation: CAB59246.1.
IPI	IPI00295511.
PIR	T34550.
RefSeq	NP_001025126.2. NM_001029955.3.
UniGene	Hs.213307.
3D structure databases
ProteinModelPortal	Q3SXM0.
SMR	Q3SXM0. Positions 198-254.
ModBase	Search...
Polymorphism databases
DMDM	121949049.
Proteomic databases
PRIDE	Q3SXM0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333141; ENSP00000327796; ENSG00000182308.
GeneID	285429.
KEGG	hsa:285429.
UCSC	uc003gwk.2. human.
Organism-specific databases
CTD	285429.
GeneCards	GC04P041983.
H-InvDB	HIX0024569.
HGNC	HGNC:27723. DCAF4L1.
neXtProt	NX_Q3SXM0.
PharmGKB	PA142670605. PA165663611.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19543.
GeneTree	ENSGT00390000009546.
HOGENOM	HBG445161.
HOVERGEN	HBG054724.
InParanoid	Q3SXM0.
OMA	NFILAST.
OrthoDB	EOG4CRM05.
Gene expression databases
ArrayExpress	Q3SXM0.
Bgee	Q3SXM0.
CleanEx	HS_WDR21B.
Genevestigator	Q3SXM0.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 2 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	95518.

Entry information

Entry name

DC4L1_HUMAN

Accession

Primary (citable) accession number: Q3SXM0
Secondary accession number(s): B3KVI3 , Q3ZCW8, Q499Y5, Q9UFI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2005
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.