ID   FPRS6_MOUSE             Reviewed;         339 AA.
AC   Q3SXG2; Q71MR8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=Formyl peptide receptor-related sequence 6;
GN   Name=Fpr-rs6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=129S6/SvEvTac;
RX   PubMed=12459252; DOI=10.1016/s0378-1119(02)01012-0;
RA   Wang Z.-G., Ye R.D.;
RT   "Characterization of two new members of the formyl peptide receptor gene
RT   family from 129S6 mice.";
RL   Gene 299:57-63(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY, AND FUNCTION.
RX   PubMed=19387439; DOI=10.1038/nature08029;
RA   Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.;
RT   "Formyl peptide receptor-like proteins are a novel family of vomeronasal
RT   chemosensors.";
RL   Nature 459:574-577(2009).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=19497865; DOI=10.1073/pnas.0904464106;
RA   Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L.,
RA   Siltberg-Liberles J., Liberles D.A., Buck L.B.;
RT   "Formyl peptide receptors are candidate chemosensory receptors in the
RT   vomeronasal organ.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009).
CC   -!- FUNCTION: May have an olfactory function associated with the
CC       identification of pathogens or of pathogenic states.
CC       {ECO:0000269|PubMed:19387439}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in vomeronasal tissue
CC       (PubMed:19387439, PubMed:19497865). Expressed in 1.2 % of a subset of
CC       sensory neurons located in the apical layer of the vomeronasal organ.
CC       Each neuron appears to express only one receptor gene. Expressed in
CC       brain, spleen, skeletal muscle and at high level in testis
CC       (PubMed:12459252). {ECO:0000269|PubMed:12459252,
CC       ECO:0000269|PubMed:19387439, ECO:0000269|PubMed:19497865}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=A sickly smell - Issue 114
CC       of February 2010;
CC       URL="https://web.expasy.org/spotlight/back_issues/114";
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DR   EMBL; AF437512; AAN63620.1; -; Genomic_DNA.
DR   EMBL; BC104318; AAI04319.1; -; mRNA.
DR   EMBL; BC104319; AAI04320.1; -; mRNA.
DR   CCDS; CCDS28423.1; -.
DR   RefSeq; NP_796290.2; NM_177316.2.
DR   AlphaFoldDB; Q3SXG2; -.
DR   SMR; Q3SXG2; -.
DR   STRING; 10090.ENSMUSP00000093296; -.
DR   GlyCosmos; Q3SXG2; 2 sites, No reported glycans.
DR   GlyGen; Q3SXG2; 2 sites.
DR   iPTMnet; Q3SXG2; -.
DR   PhosphoSitePlus; Q3SXG2; -.
DR   PaxDb; 10090-ENSMUSP00000093296; -.
DR   DNASU; 321020; -.
DR   Ensembl; ENSMUST00000095636.2; ENSMUSP00000093296.2; ENSMUSG00000071275.2.
DR   GeneID; 321020; -.
DR   KEGG; mmu:321020; -.
DR   UCSC; uc008apy.1; mouse.
DR   AGR; MGI:2448176; -.
DR   CTD; 321020; -.
DR   MGI; MGI:2448176; Fpr-rs6.
DR   VEuPathDB; HostDB:ENSMUSG00000071275; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01020000230438; -.
DR   HOGENOM; CLU_009579_8_0_1; -.
DR   InParanoid; Q3SXG2; -.
DR   OMA; ECAIKEE; -.
DR   OrthoDB; 5384006at2759; -.
DR   PhylomeDB; Q3SXG2; -.
DR   TreeFam; TF330976; -.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-444473; Formyl peptide receptors bind formyl peptides and many other ligands.
DR   BioGRID-ORCS; 321020; 2 hits in 75 CRISPR screens.
DR   PRO; PR:Q3SXG2; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q3SXG2; Protein.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0001540; F:amyloid-beta binding; ISO:MGI.
DR   GO; GO:0004875; F:complement receptor activity; IBA:GO_Central.
DR   GO; GO:0004982; F:N-formyl peptide receptor activity; IDA:MGI.
DR   GO; GO:0005124; F:scavenger receptor binding; ISO:MGI.
DR   GO; GO:0038023; F:signaling receptor activity; ISO:MGI.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:MGI.
DR   GO; GO:0019722; P:calcium-mediated signaling; ISO:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:MGI.
DR   GO; GO:1904646; P:cellular response to amyloid-beta; ISO:MGI.
DR   GO; GO:0002430; P:complement receptor mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; ISO:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR   GO; GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; ISO:MGI.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISO:MGI.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR   GO; GO:0045089; P:positive regulation of innate immune response; ISO:MGI.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISO:MGI.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISO:MGI.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000826; Formyl_rcpt-rel.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24225; CHEMOTACTIC RECEPTOR; 1.
DR   PANTHER; PTHR24225:SF17; FORMYL PEPTIDE RECEPTOR-RELATED SEQUENCE 3-RELATED; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00526; FMETLEUPHER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="Formyl peptide receptor-related sequence 6"
FT                   /id="PRO_0000382025"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..85
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..280
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        302..339
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..178
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        32
FT                   /note="V -> I (in Ref. 1; AAN63620)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        56
FT                   /note="T -> A (in Ref. 1; AAN63620)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="V -> I (in Ref. 1; AAN63620)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        277
FT                   /note="T -> A (in Ref. 1; AAN63620)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        281
FT                   /note="T -> P (in Ref. 1; AAN63620)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="T -> I (in Ref. 1; AAN63620)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   339 AA;  38154 MW;  CFC144FB2E388A62 CRC64;
     MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV AGFRMTHTVT
     TICYLNLALS DFSYMASLPF QITSIVMNGE WLFGWFLCKF VHMIINVNLF LSIFLITFIA
     MDRCICVLHP VWAQNHRTVN VATKVIFGAW ILVLMLIFPH CIFVTTVKDE SGKVHCICNF
     ESWAATPEEQ VKVSMTVSLI SVTISFIIGF SIPMIFIVIC YGLMAAKIGR RGFVNSSRPL
     RVLTAVAISF FVCWFPFQLI FLLGNIGNKE TQNNIDTWVN TASTLASFNS CLNPILYVFL
     GQQFRERLIY SLSASLERAL REDSALNSDK TRNLSSQRL
//