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Protein

Formyl peptide receptor-related sequence 6

Gene

Fpr-rs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 6
Gene namesi
Name:Fpr-rs6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2448176 Fpr-rs6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 62CytoplasmicSequence analysisAdd BLAST18
Transmembranei63 – 85Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini86 – 99ExtracellularSequence analysisAdd BLAST14
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 144CytoplasmicSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 198ExtracellularSequence analysisAdd BLAST33
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 241CytoplasmicSequence analysisAdd BLAST22
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 339CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003820251 – 339Formyl peptide receptor-related sequence 6Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3SXG2
PRIDEiQ3SXG2

PTM databases

iPTMnetiQ3SXG2
PhosphoSitePlusiQ3SXG2

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal tissue (PubMed:19387439 and PubMed:19497865). Expressed in 1.2 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in brain, spleen, skeletal muscle and at high level in testis (PubMed:12459252).3 Publications

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093296

Structurei

3D structure databases

ProteinModelPortaliQ3SXG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
InParanoidiQ3SXG2
OMAiIVINGEW
OrthoDBiEOG091G0HK2
PhylomeDBiQ3SXG2
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SXG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV
60 70 80 90 100
AGFRMTHTVT TICYLNLALS DFSYMASLPF QITSIVMNGE WLFGWFLCKF
110 120 130 140 150
VHMIINVNLF LSIFLITFIA MDRCICVLHP VWAQNHRTVN VATKVIFGAW
160 170 180 190 200
ILVLMLIFPH CIFVTTVKDE SGKVHCICNF ESWAATPEEQ VKVSMTVSLI
210 220 230 240 250
SVTISFIIGF SIPMIFIVIC YGLMAAKIGR RGFVNSSRPL RVLTAVAISF
260 270 280 290 300
FVCWFPFQLI FLLGNIGNKE TQNNIDTWVN TASTLASFNS CLNPILYVFL
310 320 330
GQQFRERLIY SLSASLERAL REDSALNSDK TRNLSSQRL
Length:339
Mass (Da):38,154
Last modified:October 11, 2005 - v1
Checksum:iCFC144FB2E388A62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32V → I in AAN63620 (PubMed:12459252).Curated1
Sequence conflicti56T → A in AAN63620 (PubMed:12459252).Curated1
Sequence conflicti107V → I in AAN63620 (PubMed:12459252).Curated1
Sequence conflicti277T → A in AAN63620 (PubMed:12459252).Curated1
Sequence conflicti281T → P in AAN63620 (PubMed:12459252).Curated1
Sequence conflicti331T → I in AAN63620 (PubMed:12459252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF437512 Genomic DNA Translation: AAN63620.1
BC104318 mRNA Translation: AAI04319.1
BC104319 mRNA Translation: AAI04320.1
CCDSiCCDS28423.1
RefSeqiNP_796290.2, NM_177316.2
UniGeneiMm.377882

Genome annotation databases

EnsembliENSMUST00000095636; ENSMUSP00000093296; ENSMUSG00000071275
GeneIDi321020
KEGGimmu:321020
UCSCiuc008apy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFPRS6_MOUSE
AccessioniPrimary (citable) accession number: Q3SXG2
Secondary accession number(s): Q71MR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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