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Q3SXG2 (FPRS6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formyl peptide receptor-related sequence 6
Gene names
Name:Fpr-rs6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have an olfactory function associated with the identification of pathogens or of pathogenic states. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed exclusively in vomeronasal tissue (Ref.3 and Ref.4). Expressed in 1.2 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in brain, spleen, skeletal muscle and at high level in testis (Ref.1). Ref.1 Ref.3 Ref.4

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Formyl peptide receptor-related sequence 6
PRO_0000382025

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 6218Cytoplasmic Potential
Transmembrane63 – 8523Helical; Name=2; Potential
Topological domain86 – 9914Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 14424Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 19833Extracellular Potential
Transmembrane199 – 21921Helical; Name=5; Potential
Topological domain220 – 24122Cytoplasmic Potential
Transmembrane242 – 26221Helical; Name=6; Potential
Topological domain263 – 28018Extracellular Potential
Transmembrane281 – 30121Helical; Name=7; Potential
Topological domain302 – 33938Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 178 By similarity

Experimental info

Sequence conflict321V → I in AAN63620. Ref.1
Sequence conflict561T → A in AAN63620. Ref.1
Sequence conflict1071V → I in AAN63620. Ref.1
Sequence conflict2771T → A in AAN63620. Ref.1
Sequence conflict2811T → P in AAN63620. Ref.1
Sequence conflict3311T → I in AAN63620. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3SXG2 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: CFC144FB2E388A62

FASTA33938,154
        10         20         30         40         50         60 
MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV AGFRMTHTVT 

        70         80         90        100        110        120 
TICYLNLALS DFSYMASLPF QITSIVMNGE WLFGWFLCKF VHMIINVNLF LSIFLITFIA 

       130        140        150        160        170        180 
MDRCICVLHP VWAQNHRTVN VATKVIFGAW ILVLMLIFPH CIFVTTVKDE SGKVHCICNF 

       190        200        210        220        230        240 
ESWAATPEEQ VKVSMTVSLI SVTISFIIGF SIPMIFIVIC YGLMAAKIGR RGFVNSSRPL 

       250        260        270        280        290        300 
RVLTAVAISF FVCWFPFQLI FLLGNIGNKE TQNNIDTWVN TASTLASFNS CLNPILYVFL 

       310        320        330 
GQQFRERLIY SLSASLERAL REDSALNSDK TRNLSSQRL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice."
Wang Z.-G., Ye R.D.
Gene 299:57-63(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129S6/SvEvTac.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
[4]"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ."
Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF437512 Genomic DNA. Translation: AAN63620.1.
BC104318 mRNA. Translation: AAI04319.1.
BC104319 mRNA. Translation: AAI04320.1.
CCDSCCDS28423.1.
RefSeqNP_796290.2. NM_177316.2.
UniGeneMm.377882.

3D structure databases

ProteinModelPortalQ3SXG2.
SMRQ3SXG2. Positions 24-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000093296.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ3SXG2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095636; ENSMUSP00000093296; ENSMUSG00000071275.
GeneID321020.
KEGGmmu:321020.
UCSCuc008apy.1. mouse.

Organism-specific databases

CTD321020.
MGIMGI:2448176. Fpr-rs6.

Phylogenomic databases

eggNOGNOG150376.
GeneTreeENSGT00730000110302.
HOGENOMHOG000234122.
InParanoidQ3SXG2.
OMATILPMEN.
PhylomeDBQ3SXG2.
TreeFamTF330976.

Gene expression databases

GenevestigatorQ3SXG2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24225. PTHR24225. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio397888.
PROQ3SXG2.
SOURCESearch...

Entry information

Entry nameFPRS6_MOUSE
AccessionPrimary (citable) accession number: Q3SXG2
Secondary accession number(s): Q71MR8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries