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Protein

Formyl peptide receptor-related sequence 6

Gene

Fpr-rs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  • N-formyl peptide receptor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_272716. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 6
Gene namesi
Name:Fpr-rs6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2448176. Fpr-rs6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 6218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei63 – 8523Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini86 – 9914ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 14424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19833ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 24122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini302 – 33938CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Formyl peptide receptor-related sequence 6PRO_0000382025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ3SXG2.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal tissue (PubMed:19387439 and PubMed:19497865). Expressed in 1.2 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in brain, spleen, skeletal muscle and at high level in testis (PubMed:12459252).3 Publications

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093296.

Structurei

3D structure databases

ProteinModelPortaliQ3SXG2.
SMRiQ3SXG2. Positions 24-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiQ3SXG2.
OMAiSANARCY.
PhylomeDBiQ3SXG2.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SXG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV
60 70 80 90 100
AGFRMTHTVT TICYLNLALS DFSYMASLPF QITSIVMNGE WLFGWFLCKF
110 120 130 140 150
VHMIINVNLF LSIFLITFIA MDRCICVLHP VWAQNHRTVN VATKVIFGAW
160 170 180 190 200
ILVLMLIFPH CIFVTTVKDE SGKVHCICNF ESWAATPEEQ VKVSMTVSLI
210 220 230 240 250
SVTISFIIGF SIPMIFIVIC YGLMAAKIGR RGFVNSSRPL RVLTAVAISF
260 270 280 290 300
FVCWFPFQLI FLLGNIGNKE TQNNIDTWVN TASTLASFNS CLNPILYVFL
310 320 330
GQQFRERLIY SLSASLERAL REDSALNSDK TRNLSSQRL
Length:339
Mass (Da):38,154
Last modified:October 11, 2005 - v1
Checksum:iCFC144FB2E388A62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321V → I in AAN63620 (PubMed:12459252).Curated
Sequence conflicti56 – 561T → A in AAN63620 (PubMed:12459252).Curated
Sequence conflicti107 – 1071V → I in AAN63620 (PubMed:12459252).Curated
Sequence conflicti277 – 2771T → A in AAN63620 (PubMed:12459252).Curated
Sequence conflicti281 – 2811T → P in AAN63620 (PubMed:12459252).Curated
Sequence conflicti331 – 3311T → I in AAN63620 (PubMed:12459252).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF437512 Genomic DNA. Translation: AAN63620.1.
BC104318 mRNA. Translation: AAI04319.1.
BC104319 mRNA. Translation: AAI04320.1.
CCDSiCCDS28423.1.
RefSeqiNP_796290.2. NM_177316.2.
UniGeneiMm.377882.

Genome annotation databases

EnsembliENSMUST00000095636; ENSMUSP00000093296; ENSMUSG00000071275.
GeneIDi321020.
KEGGimmu:321020.
UCSCiuc008apy.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF437512 Genomic DNA. Translation: AAN63620.1.
BC104318 mRNA. Translation: AAI04319.1.
BC104319 mRNA. Translation: AAI04320.1.
CCDSiCCDS28423.1.
RefSeqiNP_796290.2. NM_177316.2.
UniGeneiMm.377882.

3D structure databases

ProteinModelPortaliQ3SXG2.
SMRiQ3SXG2. Positions 24-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093296.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ3SXG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095636; ENSMUSP00000093296; ENSMUSG00000071275.
GeneIDi321020.
KEGGimmu:321020.
UCSCiuc008apy.1. mouse.

Organism-specific databases

CTDi321020.
MGIiMGI:2448176. Fpr-rs6.

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiQ3SXG2.
OMAiSANARCY.
PhylomeDBiQ3SXG2.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiREACT_272716. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi397888.
PROiQ3SXG2.
SOURCEiSearch...

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice."
    Wang Z.-G., Ye R.D.
    Gene 299:57-63(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129S6/SvEvTac.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
    Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
    Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  4. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPRS6_MOUSE
AccessioniPrimary (citable) accession number: Q3SXG2
Secondary accession number(s): Q71MR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.