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Q3SXG2

- FPRS6_MOUSE

UniProt

Q3SXG2 - FPRS6_MOUSE

Protein

Formyl peptide receptor-related sequence 6

Gene

Fpr-rs6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

    GO - Molecular functioni

    1. N-formyl peptide receptor activity Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formyl peptide receptor-related sequence 6
    Gene namesi
    Name:Fpr-rs6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2448176. Fpr-rs6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Formyl peptide receptor-related sequence 6PRO_0000382025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 178PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ3SXG2.

    Expressioni

    Tissue specificityi

    Expressed exclusively in vomeronasal tissue (PubMed:19387439 and PubMed:19497865). Expressed in 1.2 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in brain, spleen, skeletal muscle and at high level in testis (PubMed:12459252).3 Publications

    Gene expression databases

    GenevestigatoriQ3SXG2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000093296.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SXG2.
    SMRiQ3SXG2. Positions 24-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 6218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 9914ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 19833ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 24122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 33938CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei63 – 8523Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    GeneTreeiENSGT00730000110302.
    HOGENOMiHOG000234122.
    InParanoidiQ3SXG2.
    OMAiTILPMEN.
    PhylomeDBiQ3SXG2.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3SXG2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV    50
    AGFRMTHTVT TICYLNLALS DFSYMASLPF QITSIVMNGE WLFGWFLCKF 100
    VHMIINVNLF LSIFLITFIA MDRCICVLHP VWAQNHRTVN VATKVIFGAW 150
    ILVLMLIFPH CIFVTTVKDE SGKVHCICNF ESWAATPEEQ VKVSMTVSLI 200
    SVTISFIIGF SIPMIFIVIC YGLMAAKIGR RGFVNSSRPL RVLTAVAISF 250
    FVCWFPFQLI FLLGNIGNKE TQNNIDTWVN TASTLASFNS CLNPILYVFL 300
    GQQFRERLIY SLSASLERAL REDSALNSDK TRNLSSQRL 339
    Length:339
    Mass (Da):38,154
    Last modified:October 11, 2005 - v1
    Checksum:iCFC144FB2E388A62
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321V → I in AAN63620. (PubMed:12459252)Curated
    Sequence conflicti56 – 561T → A in AAN63620. (PubMed:12459252)Curated
    Sequence conflicti107 – 1071V → I in AAN63620. (PubMed:12459252)Curated
    Sequence conflicti277 – 2771T → A in AAN63620. (PubMed:12459252)Curated
    Sequence conflicti281 – 2811T → P in AAN63620. (PubMed:12459252)Curated
    Sequence conflicti331 – 3311T → I in AAN63620. (PubMed:12459252)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF437512 Genomic DNA. Translation: AAN63620.1.
    BC104318 mRNA. Translation: AAI04319.1.
    BC104319 mRNA. Translation: AAI04320.1.
    CCDSiCCDS28423.1.
    RefSeqiNP_796290.2. NM_177316.2.
    UniGeneiMm.377882.

    Genome annotation databases

    EnsembliENSMUST00000095636; ENSMUSP00000093296; ENSMUSG00000071275.
    GeneIDi321020.
    KEGGimmu:321020.
    UCSCiuc008apy.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A sickly smell - Issue 114 of February 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF437512 Genomic DNA. Translation: AAN63620.1 .
    BC104318 mRNA. Translation: AAI04319.1 .
    BC104319 mRNA. Translation: AAI04320.1 .
    CCDSi CCDS28423.1.
    RefSeqi NP_796290.2. NM_177316.2.
    UniGenei Mm.377882.

    3D structure databases

    ProteinModelPortali Q3SXG2.
    SMRi Q3SXG2. Positions 24-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000093296.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q3SXG2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095636 ; ENSMUSP00000093296 ; ENSMUSG00000071275 .
    GeneIDi 321020.
    KEGGi mmu:321020.
    UCSCi uc008apy.1. mouse.

    Organism-specific databases

    CTDi 321020.
    MGIi MGI:2448176. Fpr-rs6.

    Phylogenomic databases

    eggNOGi NOG150376.
    GeneTreei ENSGT00730000110302.
    HOGENOMi HOG000234122.
    InParanoidi Q3SXG2.
    OMAi TILPMEN.
    PhylomeDBi Q3SXG2.
    TreeFami TF330976.

    Miscellaneous databases

    NextBioi 397888.
    PROi Q3SXG2.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3SXG2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice."
      Wang Z.-G., Ye R.D.
      Gene 299:57-63(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129S6/SvEvTac.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
      Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
      Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    4. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFPRS6_MOUSE
    AccessioniPrimary (citable) accession number: Q3SXG2
    Secondary accession number(s): Q71MR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3