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Protein

Outer dense fiber protein 3-like protein 2

Gene

ODF3L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 3-like protein 2
Gene namesi
Name:ODF3L2
Synonyms:C19orf19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26841. ODF3L2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic microtubule Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181781.
PharmGKBiPA162398387.

Polymorphism and mutation databases

BioMutaiODF3L2.
DMDMi125888011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745201 – 289Outer dense fiber protein 3-like protein 2Add BLAST289

Proteomic databases

PaxDbiQ3SX64.
PRIDEiQ3SX64.

PTM databases

iPTMnetiQ3SX64.
PhosphoSitePlusiQ3SX64.

Expressioni

Gene expression databases

BgeeiENSG00000181781.
CleanExiHS_ODF3L2.
GenevisibleiQ3SX64. HS.

Organism-specific databases

HPAiHPA067973.

Interactioni

Protein-protein interaction databases

BioGridi129881. 9 interactors.
IntActiQ3SX64. 2 interactors.
STRINGi9606.ENSP00000318029.

Structurei

3D structure databases

ProteinModelPortaliQ3SX64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati122 – 148STPGR 1Add BLAST27
Repeati202 – 227STPGR 2Add BLAST26
Repeati238 – 263STPGR 3Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 245Pro-richAdd BLAST128

Sequence similaritiesi

Belongs to the ODF3 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IVVZ. Eukaryota.
ENOG4111FDE. LUCA.
GeneTreeiENSGT00440000039820.
HOGENOMiHOG000090412.
HOVERGENiHBG054464.
InParanoidiQ3SX64.
OMAiFSMLGRH.
OrthoDBiEOG091G09K4.
PhylomeDBiQ3SX64.
TreeFamiTF325804.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3SX64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTLSCDSTP RLATAPLGRR VTEGQIPETG LRKSCGTATL ENGSGPGLYV
60 70 80 90 100
LPSTVGFINH DCTRVASPAY SLVRRPSEAP PQDTSPGPIY FLDPKVTRFG
110 120 130 140 150
RSCTPAYSMQ GRAKSRGPEV TPGPGAYSPE KVPPVRHRTP PAFTLGCRLP
160 170 180 190 200
LKPLDTSAPA PNAYTMPPLW GSQIFTKPSS PSYTVVGRTP PARPPQDPAE
210 220 230 240 250
IPGPGQYDSP DANTYRQRLP AFTMLGRPRA PRPLEETPGP GAHCPEQVTV
260 270 280
NKARAPAFSM GIRHSKRAST MAATTPSRPA GHRLPGRCC
Length:289
Mass (Da):30,781
Last modified:February 6, 2007 - v2
Checksum:i79748C1683D5935C
GO
Isoform 2 (identifier: Q3SX64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-78: Missing.

Show »
Length:253
Mass (Da):26,995
Checksum:iDF5DAE98422D9831
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053951135V → A.1 PublicationCorresponds to variant rs34551779dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02277843 – 78Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097378 mRNA. Translation: BAC05028.1.
BC104468 mRNA. Translation: AAI04469.1.
BC104469 mRNA. Translation: AAI04470.1.
CCDSiCCDS12027.1. [Q3SX64-1]
RefSeqiNP_872383.1. NM_182577.2. [Q3SX64-1]
UniGeneiHs.104777.

Genome annotation databases

EnsembliENST00000315489; ENSP00000318029; ENSG00000181781. [Q3SX64-1]
ENST00000382696; ENSP00000372143; ENSG00000181781. [Q3SX64-2]
GeneIDi284451.
KEGGihsa:284451.
UCSCiuc002lor.3. human. [Q3SX64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097378 mRNA. Translation: BAC05028.1.
BC104468 mRNA. Translation: AAI04469.1.
BC104469 mRNA. Translation: AAI04470.1.
CCDSiCCDS12027.1. [Q3SX64-1]
RefSeqiNP_872383.1. NM_182577.2. [Q3SX64-1]
UniGeneiHs.104777.

3D structure databases

ProteinModelPortaliQ3SX64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129881. 9 interactors.
IntActiQ3SX64. 2 interactors.
STRINGi9606.ENSP00000318029.

PTM databases

iPTMnetiQ3SX64.
PhosphoSitePlusiQ3SX64.

Polymorphism and mutation databases

BioMutaiODF3L2.
DMDMi125888011.

Proteomic databases

PaxDbiQ3SX64.
PRIDEiQ3SX64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315489; ENSP00000318029; ENSG00000181781. [Q3SX64-1]
ENST00000382696; ENSP00000372143; ENSG00000181781. [Q3SX64-2]
GeneIDi284451.
KEGGihsa:284451.
UCSCiuc002lor.3. human. [Q3SX64-1]

Organism-specific databases

CTDi284451.
GeneCardsiODF3L2.
HGNCiHGNC:26841. ODF3L2.
HPAiHPA067973.
neXtProtiNX_Q3SX64.
OpenTargetsiENSG00000181781.
PharmGKBiPA162398387.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVVZ. Eukaryota.
ENOG4111FDE. LUCA.
GeneTreeiENSGT00440000039820.
HOGENOMiHOG000090412.
HOVERGENiHBG054464.
InParanoidiQ3SX64.
OMAiFSMLGRH.
OrthoDBiEOG091G09K4.
PhylomeDBiQ3SX64.
TreeFamiTF325804.

Miscellaneous databases

GenomeRNAii284451.
PROiQ3SX64.

Gene expression databases

BgeeiENSG00000181781.
CleanExiHS_ODF3L2.
GenevisibleiQ3SX64. HS.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOD3L2_HUMAN
AccessioniPrimary (citable) accession number: Q3SX64
Secondary accession number(s): Q3SX65, Q8N1L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.