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Protein

C1GALT1-specific chaperone 1

Gene

C1GALT1C1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-BTA-913709. O-linked glycosylation of mucins.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
C1GALT1-specific chaperone 1
Gene namesi
Name:C1GALT1C1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2620Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini27 – 318292LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318C1GALT1-specific chaperone 1PRO_0000285073Add
BLAST

Proteomic databases

PaxDbiQ3SX46.
PRIDEiQ3SX46.

Interactioni

Subunit structurei

Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028542.

Structurei

3D structure databases

ProteinModelPortaliQ3SX46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 4317His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000013033.
HOVERGENiHBG059493.
InParanoidiQ3SX46.
KOiK09653.
OMAiCLKYTGV.
OrthoDBiEOG7ZGX3B.
TreeFamiTF317293.

Family and domain databases

InterProiIPR026731. C1GALT1C1.
[Graphical view]
PANTHERiPTHR23033:SF2. PTHR23033:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SX46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSESSSFLK GVMLGSIFCA LITMLGHIRI GHGSRMHHHE HHHLQAPNKE
60 70 80 90 100
DILKISEDER MELSKSFRVY CILLVRPKDV SLWAAVKETW TNHCDKVDFF
110 120 130 140 150
SSENVKVFES INMETNDMWL MMRKAYKYAF DKYRDQYNWF FLARPTTFAI
160 170 180 190 200
IENLKYFLLK KDPSQPFYLG HTVKSGDLEY VSMEGGIVLS IESMKRLNSL
210 220 230 240 250
LSIPEKCPEQ GGMIWKISED KQLAVCLKYA GVFAENAEDS EGKDIFNTKS
260 270 280 290 300
VGLFIKEAMT NHPNQVVEGC CSDMAVTFNG LTPNQMHVMM YGVYRLRAFG
310
HVFNDALVFL PPNGSDND
Length:318
Mass (Da):36,441
Last modified:October 11, 2005 - v1
Checksum:i503202E70EA79C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104496 mRNA. Translation: AAI04497.1.
RefSeqiNP_001029747.1. NM_001034575.1.
XP_005227521.1. XM_005227464.3.
XP_015316903.1. XM_015461417.1.
UniGeneiBt.25433.

Genome annotation databases

EnsembliENSBTAT00000028542; ENSBTAP00000028542; ENSBTAG00000021410.
GeneIDi531644.
KEGGibta:531644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104496 mRNA. Translation: AAI04497.1.
RefSeqiNP_001029747.1. NM_001034575.1.
XP_005227521.1. XM_005227464.3.
XP_015316903.1. XM_015461417.1.
UniGeneiBt.25433.

3D structure databases

ProteinModelPortaliQ3SX46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028542.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

PaxDbiQ3SX46.
PRIDEiQ3SX46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028542; ENSBTAP00000028542; ENSBTAG00000021410.
GeneIDi531644.
KEGGibta:531644.

Organism-specific databases

CTDi29071.

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000013033.
HOVERGENiHBG059493.
InParanoidiQ3SX46.
KOiK09653.
OMAiCLKYTGV.
OrthoDBiEOG7ZGX3B.
TreeFamiTF317293.

Enzyme and pathway databases

ReactomeiR-BTA-913709. O-linked glycosylation of mucins.

Family and domain databases

InterProiIPR026731. C1GALT1C1.
[Graphical view]
PANTHERiPTHR23033:SF2. PTHR23033:SF2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiC1GLC_BOVIN
AccessioniPrimary (citable) accession number: Q3SX46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.