Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

Gene

DDAH2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity).By similarity

Catalytic activityi

N(omega),N(omega)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Proton donorBy similarity1
Active sitei276NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.5.3.18 908
ReactomeiR-BTA-203615 eNOS activation

Names & Taxonomyi

Protein namesi
Recommended name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (EC:3.5.3.18)
Short name:
DDAH-2
Short name:
Dimethylarginine dimethylaminohydrolase 2
Alternative name(s):
DDAHII
Dimethylargininase-2
Gene namesi
Name:DDAH2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:27940 DDAH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002707591 – 285N(G),N(G)-dimethylarginine dimethylaminohydrolase 2Add BLAST285

Proteomic databases

PaxDbiQ3SX44
PeptideAtlasiQ3SX44
PRIDEiQ3SX44

Expressioni

Gene expression databases

BgeeiENSBTAG00000013530

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017991

Structurei

3D structure databases

ProteinModelPortaliQ3SX44
SMRiQ3SX44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDAH family.Curated

Phylogenomic databases

eggNOGiENOG410ISNS Eukaryota
ENOG4111YMV LUCA
GeneTreeiENSGT00390000009331
HOGENOMiHOG000161035
HOVERGENiHBG055937
InParanoidiQ3SX44
KOiK01482
OMAiCPYGRFT
OrthoDBiEOG091G0M5S
TreeFamiTF314737

Family and domain databases

InterProiView protein in InterPro
IPR033199 DDAH/AD
IPR033202 DDAH2
PANTHERiPTHR12737 PTHR12737, 1 hit
PTHR12737:SF16 PTHR12737:SF16, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SX44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPGEGLGR CSHALIRGVP ESLASGEGAA AGLPALDLAK AQREHGVLGG
60 70 80 90 100
KLRQRLGLQL VELPPEESLP LGPLLGDTAV IQGDTALITR PWSPARRPEV
110 120 130 140 150
DGVRKALQDL GLRIVEMGDE NATLDGTDVL FTGREFFVGL SKWTNHRGAE
160 170 180 190 200
IVADTFRDFA VSTVPVTSTS HLRGLCGMGG PRTVVAGSSE AAQKAVRAMA
210 220 230 240 250
VLTDHPYASL TLPDDAAADC LFLRPGQPGL PPFLLHRGGG DLPNSQEALQ
260 270 280
KLSDVTLVPV SCSELEKAGA GLSSLCLVLS TRPHN
Length:285
Mass (Da):29,780
Last modified:October 11, 2005 - v1
Checksum:i663378431BEF4152
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104509 mRNA Translation: AAI04510.1
RefSeqiNP_001029876.1, NM_001034704.1
XP_005223736.1, XM_005223679.3
UniGeneiBt.57614

Genome annotation databases

EnsembliENSBTAT00000017991; ENSBTAP00000017991; ENSBTAG00000013530
GeneIDi540386
KEGGibta:540386

Similar proteinsi

Entry informationi

Entry nameiDDAH2_BOVIN
AccessioniPrimary (citable) accession number: Q3SX44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health