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Protein

Luc7-like protein 3

Gene

LUC7L3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Luc7-like protein 3
Alternative name(s):
Cisplatin resistance-associated-overexpressed protein
Gene namesi
Name:LUC7L3
Synonyms:CROP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002334101 – 432Luc7-like protein 3Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei231N6-acetyllysineBy similarity1
Modified residuei420PhosphoserineBy similarity1
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei425PhosphoserineBy similarity1
Modified residuei431PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3SX41.
PeptideAtlasiQ3SX41.
PRIDEiQ3SX41.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002279.

Interactioni

Subunit structurei

May interact with SFRS1 and form homodimers. Interacts with JMJD6 and RBM25 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002938.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili124 – 181Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi228 – 282Glu-richAdd BLAST55
Compositional biasi235 – 395Arg/Ser-richAdd BLAST161

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOGENOMiHOG000215956.
HOVERGENiHBG062167.
InParanoidiQ3SX41.
OMAiSQLFCSR.
OrthoDBiEOG091G0HXI.
TreeFamiTF354312.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SX41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAAQLLDE LMGRDRNLAP DEKRSNVRWD HESVCKYYLC GFCPAELFTN
60 70 80 90 100
TRSDLGPCEK IHDENLRKQY EKSSRFMKVG YERDFLRYLQ SLLAEVERRI
110 120 130 140 150
RRGHARLALS QNQQSSGAAG PTGKNEEKIQ VLTDKIDVLL QQIEELGSEG
160 170 180 190 200
KVEEAQGMMK LVEQLKEERE LLRSTTSTIE SFAAQEKQME VCEVCGAFLI
210 220 230 240 250
VGDAQSRVDD HLMGKQHMGY AKIKATVEEL KEKLRKRTEE PDRDERLKKE
260 270 280 290 300
KQEREEREKE REREREERER KRRREEEERE KERARDRERR KRSRSRSRHS
310 320 330 340 350
SRTSDRRCSR SRDHKRSRSR ERRRSRSRDR RRSRSHDRSE RKHRSRSRDR
360 370 380 390 400
RRSKSRDRKS YKHRSKSRDR EQDRKSKEKE KRGSDDKKSS VKSSSREKQS
410 420 430
EDTNTESKES DTKNEVNGTS EDIKSEGDTQ SN
Length:432
Mass (Da):51,496
Last modified:October 11, 2005 - v1
Checksum:i525B55EC01372D11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104519 mRNA. Translation: AAI04520.1.
RefSeqiNP_001029856.1. NM_001034684.1.
XP_005220659.1. XM_005220602.1.
UniGeneiBt.1595.

Genome annotation databases

EnsembliENSBTAT00000002938; ENSBTAP00000002938; ENSBTAG00000002279.
GeneIDi539955.
KEGGibta:539955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104519 mRNA. Translation: AAI04520.1.
RefSeqiNP_001029856.1. NM_001034684.1.
XP_005220659.1. XM_005220602.1.
UniGeneiBt.1595.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002938.

Proteomic databases

PaxDbiQ3SX41.
PeptideAtlasiQ3SX41.
PRIDEiQ3SX41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002938; ENSBTAP00000002938; ENSBTAG00000002279.
GeneIDi539955.
KEGGibta:539955.

Organism-specific databases

CTDi51747.

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOGENOMiHOG000215956.
HOVERGENiHBG062167.
InParanoidiQ3SX41.
OMAiSQLFCSR.
OrthoDBiEOG091G0HXI.
TreeFamiTF354312.

Gene expression databases

BgeeiENSBTAG00000002279.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLC7L3_BOVIN
AccessioniPrimary (citable) accession number: Q3SX41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.