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Q3SX24 (FBX6_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
F-box only protein 6
Alternative name(s):
F-box protein that recognizes sugar chains 2
Gene names
Name:FBXO6
Synonyms:FBS2, FBX6
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with VCP, CHEK1 and CUL1 By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 1 FBA (F-box associated) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265F-box only protein 6
PRO_0000385626

Regions

Domain3 – 5048F-box
Domain71 – 252182FBA

Sequences

Sequence LengthMass (Da)Tools
Q3SX24 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 49506F70B568E5F5

FASTA26530,767
        10         20         30         40         50         60 
MALVSINQLP ENILLEVFMH VPARQLLRNC RPVCCLWRDL IDLVSLWKRK CLREGYVTED 

        70         80         90        100        110        120 
WDQPVSDWKV FYFLCSLRRN LLRNPCAEED MKSWKIDSNG GDQWKVESLP GAHGTGFPDS 

       130        140        150        160        170        180 
KVKKYFVTSY DMCLKSQIID LKAEGYWEEL LDKFRPDIVV KDWFAPRADC GCTYQIRVQL 

       190        200        210        220        230        240 
ASADYLVLAS FEPPPVTIHQ WNDAKWTEVS HTFSDYPPGV RHIFFQHGGK DTQFWAGWYG 

       250        260 
PRVTNSSVVI SHRVTRNPPH AMAQP

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT030507 mRNA. Translation: ABQ12947.1.
BC104546 mRNA. Translation: AAI04547.1.
IPIIPI00700547.
RefSeqNP_001029605.1. NM_001034433.1.
UniGeneBt.20525.

3D structure databases

ProteinModelPortalQ3SX24.
SMRQ3SX24. Positions 70-251.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000034071.

Proteomic databases

PRIDEQ3SX24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000034170; ENSBTAP00000034071; ENSBTAG00000014777.
GeneID513023.
KEGGbta:513023.

Organism-specific databases

CTD26270.

Phylogenomic databases

eggNOGNOG73046.
GeneTreeENSGT00390000003865.
HOGENOMHOG000231084.
InParanoidQ3SX24.
KOK10100.
OMAPCAEEDM.
OrthoDBEOG4VX267.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

InterProIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom_cyclin-like.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamPF04300. FBA. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF81383. F-box_dom_Skp2-like. 1 hit.
SSF49785. Gal_bind_like. 1 hit.
PROSITEPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870662.

Entry information

Entry nameFBX6_BOVIN
AccessionPrimary (citable) accession number: Q3SX24
Entry history
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: October 11, 2005
Last modified: April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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