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Protein

Dual specificity protein kinase CLK3

Gene

CLK3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei186ATPPROSITE-ProRule annotation1
Active sitei283Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 170ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein kinase CLK3 (EC:2.7.12.1)
Alternative name(s):
CDC-like kinase 3
Gene namesi
Name:CLK3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:27450 CLK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482831 – 490Dual specificity protein kinase CLK3Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphotyrosineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylates on all three types of residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SX21
PRIDEiQ3SX21

Expressioni

Gene expression databases

BgeeiENSBTAG00000007304

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009609

Structurei

3D structure databases

ProteinModelPortaliQ3SX21
SMRiQ3SX21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 472Protein kinasePROSITE-ProRule annotationAdd BLAST317

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0671 Eukaryota
ENOG410XQF2 LUCA
GeneTreeiENSGT00580000081366
HOGENOMiHOG000203417
HOVERGENiHBG107720
InParanoidiQ3SX21
KOiK08823
OMAiWDENTSD
OrthoDBiEOG091G033A
TreeFamiTF101041

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SX21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR
60 70 80 90 100
SHDRLPYQRR YREHRDSDTY RCEDRSPSFG EDYYGSSRCH HRRRSREREP
110 120 130 140 150
YRTRKHAHHC HKRRTRSCSS ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD
160 170 180 190 200
WLQERYEIVG NLGEGTFGKV VECLDHARGK SQVALKIIRN VGKYREAARL
210 220 230 240 250
EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG KNTFEFLKEN
260 270 280 290 300
NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY
310 320 330 340 350
NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG
360 370 380 390 400
WAQPCDVWSI GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR
410 420 430 440 450
TRKQKYFYKG GLVWDENSSD GRYVKENCKP LKSYMLQDTL EHVQLFDLMR
460 470 480 490
RMLEFDPAQR ITLAEALLHP FFAGLTPEER SFHTSRNPSR
Length:490
Mass (Da):58,628
Last modified:October 11, 2005 - v1
Checksum:i0BA34A089F25B697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104550 mRNA Translation: AAI04551.1
RefSeqiNP_001029420.1, NM_001034248.1
XP_005221975.1, XM_005221918.3
UniGeneiBt.111440

Genome annotation databases

EnsembliENSBTAT00000009609; ENSBTAP00000009609; ENSBTAG00000007304
GeneIDi505499
KEGGibta:505499

Similar proteinsi

Entry informationi

Entry nameiCLK3_BOVIN
AccessioniPrimary (citable) accession number: Q3SX21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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