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Q3SX21 (CLK3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dual specificity protein kinase CLK3
EC=2.7.12.1
Alternative name(s):
CDC-like kinase 3
Gene names
Name:CLK3
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesicle › secretory vesicle › acrosome By similarity.

Post-translational modification

Autophosphorylates on all three types of residues By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Dual specificity protein kinase CLK3
PRO_0000248283

Regions

Domain156 – 472317Protein kinase
Nucleotide binding162 – 1709ATP By similarity

Sites

Active site2831Proton acceptor By similarity
Binding site1861ATP By similarity

Amino acid modifications

Modified residue71Phosphotyrosine By similarity
Modified residue91Phosphoserine By similarity
Modified residue491Phosphoserine By similarity
Modified residue511Phosphoserine By similarity
Modified residue671Phosphoserine By similarity
Modified residue761Phosphoserine By similarity
Modified residue781Phosphoserine By similarity
Modified residue1351Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SX21 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 0BA34A089F25B697

FASTA49058,628
        10         20         30         40         50         60 
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR SHDRLPYQRR 

        70         80         90        100        110        120 
YREHRDSDTY RCEDRSPSFG EDYYGSSRCH HRRRSREREP YRTRKHAHHC HKRRTRSCSS 

       130        140        150        160        170        180 
ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD WLQERYEIVG NLGEGTFGKV VECLDHARGK 

       190        200        210        220        230        240 
SQVALKIIRN VGKYREAARL EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG 

       250        260        270        280        290        300 
KNTFEFLKEN NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY 

       310        320        330        340        350        360 
NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG WAQPCDVWSI 

       370        380        390        400        410        420 
GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR TRKQKYFYKG GLVWDENSSD 

       430        440        450        460        470        480 
GRYVKENCKP LKSYMLQDTL EHVQLFDLMR RMLEFDPAQR ITLAEALLHP FFAGLTPEER 

       490 
SFHTSRNPSR

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC104550 mRNA. Translation: AAI04551.1.
IPIIPI00705910.
RefSeqNP_001029420.1. NM_001034248.1.
UniGeneBt.59406.

3D structure databases

HSSPHSSP built from PDB template 2EU9 based on UniProtKB P49761.
ProteinModelPortalQ3SX21.
SMRQ3SX21. Positions 136-481.
ModBaseSearch...

Proteomic databases

PRIDEQ3SX21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000009609; ENSBTAP00000009609; ENSBTAG00000007304.
GeneID505499.
KEGGbta:505499.

Organism-specific databases

CTD1198.

Phylogenomic databases

eggNOGmaNOG14181.
GeneTreeENSGT00580000081366.
HOVERGENHBG107720.
InParanoidQ3SX21.
OrthoDBEOG49ZXP2.
PhylomeDBQ3SX21.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
KOK08823.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLK3_BOVIN
AccessionPrimary (citable) accession number: Q3SX21
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2005
Last modified: November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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