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Protein

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Gene

ECSIT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).By similarity
Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-BTA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Gene namesi
Name:ECSIT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4848MitochondrionSequence analysisAdd
BLAST
Chaini49 – 433385Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialPRO_0000291984Add
BLAST

Proteomic databases

PaxDbiQ3SX05.
PRIDEiQ3SX05.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015049.

Interactioni

Subunit structurei

Interacts with MAP3K1, NDUFAF1, SMAD4 and TRAF6 (By similarity). Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with ACAD9 (By similarity). Interacts with TRIM59 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020029.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi410 – 4156Poly-Pro

Sequence similaritiesi

Belongs to the ECSIT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3941. Eukaryota.
ENOG41100I6. LUCA.
GeneTreeiENSGT00390000005147.
HOGENOMiHOG000112324.
HOVERGENiHBG059532.
InParanoidiQ3SX05.
KOiK04405.
OMAiNMADFGV.
OrthoDBiEOG091G07N5.
TreeFamiTF314943.

Family and domain databases

InterProiIPR029342. ECIST_C.
IPR010418. ECSIT.
[Graphical view]
PANTHERiPTHR13113. PTHR13113. 1 hit.
PfamiPF14784. ECIST_C. 1 hit.
PF06239. ECSIT. 1 hit.
[Graphical view]
SMARTiSM01284. ECSIT_Cterm. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SX05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWAQAILLA RGASRGWGGI CSTALTGAPF SQVPPQAPRG LRCSAAAHNP
60 70 80 90 100
DSSLVPHPPE PPRRPVKALA VHEELFRPAL DGARNKANFV RAVQNFTEYN
110 120 130 140 150
VHKRGHVDFI YLALRKMREY GVERDLSVYN LLLDIFPKEV FRPRNIFHSI
160 170 180 190 200
FLHYPRQQEC GIAVLEQMEN HGVMPNKETE FLLLQIFGRK SYPMLKLVRM
210 220 230 240 250
KLWFTRFKNI NPFPVPRDLP QDPVDLASLA LRHMEPDLSA RVTTYQMPLL
260 270 280 290 300
KDSPNAMDPT ETHIVGIQSP EQQSALARHD PARPIFVEGP FSLWLRDKCV
310 320 330 340 350
YYHILRADLL PPEEREVEEI PEEWNLYYPM QLDLAYGRSS WDDYEFNIDE
360 370 380 390 400
VEEGPVFAIC VAGAHDQATL AKWIQGLQET NPALARIPVV FRLSGSSGEL
410 420 430
LPSSSELEEP PPPPPEGQEE EEDSQQRQQQ GQS
Length:433
Mass (Da):49,251
Last modified:October 11, 2005 - v1
Checksum:i8698F263AB81E449
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104572 mRNA. Translation: AAI04573.1.
RefSeqiNP_001029458.1. NM_001034286.1.
XP_010805109.1. XM_010806807.2.
UniGeneiBt.2894.

Genome annotation databases

EnsembliENSBTAT00000020029; ENSBTAP00000020029; ENSBTAG00000015049.
GeneIDi507245.
KEGGibta:507245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104572 mRNA. Translation: AAI04573.1.
RefSeqiNP_001029458.1. NM_001034286.1.
XP_010805109.1. XM_010806807.2.
UniGeneiBt.2894.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020029.

Proteomic databases

PaxDbiQ3SX05.
PRIDEiQ3SX05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020029; ENSBTAP00000020029; ENSBTAG00000015049.
GeneIDi507245.
KEGGibta:507245.

Organism-specific databases

CTDi51295.

Phylogenomic databases

eggNOGiKOG3941. Eukaryota.
ENOG41100I6. LUCA.
GeneTreeiENSGT00390000005147.
HOGENOMiHOG000112324.
HOVERGENiHBG059532.
InParanoidiQ3SX05.
KOiK04405.
OMAiNMADFGV.
OrthoDBiEOG091G07N5.
TreeFamiTF314943.

Enzyme and pathway databases

ReactomeiR-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000015049.

Family and domain databases

InterProiIPR029342. ECIST_C.
IPR010418. ECSIT.
[Graphical view]
PANTHERiPTHR13113. PTHR13113. 1 hit.
PfamiPF14784. ECIST_C. 1 hit.
PF06239. ECSIT. 1 hit.
[Graphical view]
SMARTiSM01284. ECSIT_Cterm. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECSIT_BOVIN
AccessioniPrimary (citable) accession number: Q3SX05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.