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Protein

Trans-L-3-hydroxyproline dehydratase

Gene

L3HYPDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C).By similarity

Catalytic activityi

Trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton acceptorBy similarity
Binding sitei269 – 2691SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-L-3-hydroxyproline dehydratase (EC:4.2.1.77)
Alternative name(s):
Trans-3-hydroxy-L-proline dehydratase
Gene namesi
Name:L3HYPDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Trans-L-3-hydroxyproline dehydratasePRO_0000288948Add
BLAST

Proteomic databases

PaxDbiQ3SX04.
PRIDEiQ3SX04.

Expressioni

Gene expression databases

BgeeiENSBTAG00000030824.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3SX04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1062Substrate bindingBy similarity
Regioni274 – 2752Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the proline racemase family.Curated

Phylogenomic databases

eggNOGiENOG410IIC6. Eukaryota.
COG3938. LUCA.
GeneTreeiENSGT00390000002032.
HOGENOMiHOG000084336.
HOVERGENiHBG057443.
InParanoidiQ3SX04.
KOiK18384.
OMAiARMAQWY.
OrthoDBiEOG091G0CI6.
TreeFamiTF329167.

Family and domain databases

InterProiIPR008794. Pro_racemase_fam.
[Graphical view]
PfamiPF05544. Pro_racemase. 1 hit.
[Graphical view]
PIRSFiPIRSF029792. Pro_racemase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SX04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLTVPWM PPHDPGTPAL SVVDMHTGGE PLRIVLAGCP EVVGPTLLAK
60 70 80 90 100
RRYMRQHLDH VRRRLMFEPR GHRDMYGAVL VPSELPDAHL GVLFLNNEGY
110 120 130 140 150
SSMCGHAVLA LGRFALDFGL VPAPPSDAQE ALVNIHCPCG LVAAFVECEG
160 170 180 190 200
CRSRGPVRFH SVPAFVLATD FLVDVPGRGK VVVDIAYGGA FYAFVSAEKL
210 220 230 240 250
GLDVCSAKMG DLVAAASAVT EAVKAQFKIS HPDSEDLAFL YGTILTDGKD
260 270 280 290 300
TYNEEPTTNI CVFADEQVDR SPTGSGVTAR IALQYHKGLL ELNQTRAFKS
310 320 330 340 350
SATGSVFTGK AVREAKCGDF KAVIVEVSGQ AHYTGTASFI VEDDDPLRDG

FLLK
Length:354
Mass (Da):37,957
Last modified:October 11, 2005 - v1
Checksum:i997C31A237A82510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104573 mRNA. Translation: AAI04574.1.
RefSeqiNP_001029558.1. NM_001034386.1.
UniGeneiBt.30092.

Genome annotation databases

EnsembliENSBTAT00000004371; ENSBTAP00000004371; ENSBTAG00000030824.
GeneIDi510525.
KEGGibta:510525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104573 mRNA. Translation: AAI04574.1.
RefSeqiNP_001029558.1. NM_001034386.1.
UniGeneiBt.30092.

3D structure databases

ProteinModelPortaliQ3SX04.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ3SX04.
PRIDEiQ3SX04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004371; ENSBTAP00000004371; ENSBTAG00000030824.
GeneIDi510525.
KEGGibta:510525.

Organism-specific databases

CTDi112849.

Phylogenomic databases

eggNOGiENOG410IIC6. Eukaryota.
COG3938. LUCA.
GeneTreeiENSGT00390000002032.
HOGENOMiHOG000084336.
HOVERGENiHBG057443.
InParanoidiQ3SX04.
KOiK18384.
OMAiARMAQWY.
OrthoDBiEOG091G0CI6.
TreeFamiTF329167.

Gene expression databases

BgeeiENSBTAG00000030824.

Family and domain databases

InterProiIPR008794. Pro_racemase_fam.
[Graphical view]
PfamiPF05544. Pro_racemase. 1 hit.
[Graphical view]
PIRSFiPIRSF029792. Pro_racemase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiT3HPD_BOVIN
AccessioniPrimary (citable) accession number: Q3SX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.