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Protein

Ribosome maturation protein SBDS

Gene

SBDS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome maturation protein SBDS
Alternative name(s):
Shwachman-Bodian-Diamond syndrome protein homolog
Gene namesi
Name:SBDS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:34304 SBDS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002455772 – 250Ribosome maturation protein SBDSAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei238PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SWZ6
PeptideAtlasiQ3SWZ6
PRIDEiQ3SWZ6

Expressioni

Gene expression databases

BgeeiENSBTAG00000004051

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005296

Structurei

3D structure databases

ProteinModelPortaliQ3SWZ6
SMRiQ3SWZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDO1/SBDS family.Curated

Phylogenomic databases

eggNOGiKOG2917 Eukaryota
COG1500 LUCA
GeneTreeiENSGT00390000008135
HOGENOMiHOG000216685
HOVERGENiHBG039762
InParanoidiQ3SWZ6
KOiK14574
OMAiAVNPQMD
OrthoDBiEOG091G0GOU
TreeFamiTF300881

Family and domain databases

Gene3Di1.10.10.900, 1 hit
3.30.1250.10, 1 hit
InterProiView protein in InterPro
IPR018978 Ribosome_mat_SBDS_C
IPR018023 Ribosome_mat_SBDS_CS
IPR019783 Ribosome_mat_SBDS_N
IPR036786 Ribosome_mat_SBDS_N_sf
IPR002140 Sdo1/SBDS
IPR037188 Sdo1/SBDS_central_sf
PANTHERiPTHR10927:SF1 PTHR10927:SF1, 1 hit
PfamiView protein in Pfam
PF01172 SBDS, 1 hit
PF09377 SBDS_C, 1 hit
SUPFAMiSSF109728 SSF109728, 1 hit
SSF89895 SSF89895, 1 hit
TIGRFAMsiTIGR00291 RNA_SBDS, 1 hit
PROSITEiView protein in PROSITE
PS01267 UPF0023, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SWZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFTPTNQI RLTNVAVVRM KRAGKRFEIA CYKNKVVGWR SGVEKDLDEV
60 70 80 90 100
LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER
110 120 130 140 150
HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKPNKST
160 170 180 190 200
KQQALEVIKQ LKEKMKIERA HMRLRFILPV NEGKKLKEKL KPLIKVIESE
210 220 230 240 250
DYGQQLEIVC LIDPGCFREV DELIKKETKG KGSLEVLSLK DVEEGDEKFE
Length:250
Mass (Da):28,718
Last modified:October 11, 2005 - v1
Checksum:i5D8C1245327DAB02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104585 mRNA Translation: AAI04586.1
RefSeqiNP_001029611.1, NM_001034439.1
UniGeneiBt.12631

Genome annotation databases

EnsembliENSBTAT00000005296; ENSBTAP00000005296; ENSBTAG00000004051
GeneIDi513237
KEGGibta:513237

Similar proteinsi

Entry informationi

Entry nameiSBDS_BOVIN
AccessioniPrimary (citable) accession number: Q3SWZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health