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Q3SWZ3

- STX4_BOVIN

UniProt

Q3SWZ3 - STX4_BOVIN

Protein

Syntaxin-4

Gene

STX4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: AgBase

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. neurotransmitter transport Source: UniProtKB-KW
    3. vesicle-mediated transport Source: InterPro

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_216751. Clathrin derived vesicle budding.
    REACT_217718. Translocation of GLUT4 to the plasma membrane.
    REACT_220570. Disinhibition of SNARE formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-4
    Gene namesi
    Name:STX4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. caveola Source: AgBase
    3. cell surface Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. lateral loop Source: Ensembl
    6. myelin sheath adaxonal region Source: Ensembl
    7. perinuclear region of cytoplasm Source: Ensembl
    8. SNARE complex Source: UniProtKB
    9. specific granule Source: Ensembl
    10. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Syntaxin-4PRO_0000282875Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphoserineBy similarity
    Modified residuei15 – 151PhosphoserineBy similarity
    Modified residuei117 – 1171PhosphoserineBy similarity
    Modified residuei248 – 2481PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ3SWZ3.

    Interactioni

    Subunit structurei

    Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009899.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SWZ3.
    SMRiQ3SWZ3. Positions 200-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 275275CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 2971ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei276 – 29621Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini200 – 26263t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili43 – 163121Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    GeneTreeiENSGT00730000110677.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiQ3SWZ3.
    KOiK13502.
    OMAiRMIQQRT.
    OrthoDBiEOG7X9G7R.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3SWZ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDRTHELRQ GDDSSDDEDK ERVALVVHPG TARLGSPDDE FFQKVRTIRQ    50
    TIVKLENKVR ELEKQQVTIL ATPLPEESMK QDLQNLRDEI KQLGRDIRAQ 100
    LKAIEPQKEE ADENYNSVNT RMRKTQHGVL SQQFVELINK CNLMQSEYRE 150
    KNVERIRRQL KITNAGMVSD KELEQMLDSG QSEVFVSNIL KDTQVTRQAL 200
    NEISARHSEI QQLERSIREL HEIFTFLATE VEMQGEMINR IEKNILSSAD 250
    YVERGQEHVK VALENQKKAR KKKVFIAICL SITVLILVVI IVISTLV 297
    Length:297
    Mass (Da):34,400
    Last modified:October 11, 2005 - v1
    Checksum:i5CAE09860DD5C422
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104588 mRNA. Translation: AAI04589.1.
    RefSeqiNP_001030236.1. NM_001035064.1.
    UniGeneiBt.3076.

    Genome annotation databases

    EnsembliENSBTAT00000009899; ENSBTAP00000009899; ENSBTAG00000007523.
    GeneIDi508675.
    KEGGibta:508675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104588 mRNA. Translation: AAI04589.1 .
    RefSeqi NP_001030236.1. NM_001035064.1.
    UniGenei Bt.3076.

    3D structure databases

    ProteinModelPortali Q3SWZ3.
    SMRi Q3SWZ3. Positions 200-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009899.

    Proteomic databases

    PRIDEi Q3SWZ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000009899 ; ENSBTAP00000009899 ; ENSBTAG00000007523 .
    GeneIDi 508675.
    KEGGi bta:508675.

    Organism-specific databases

    CTDi 6810.

    Phylogenomic databases

    eggNOGi COG5074.
    GeneTreei ENSGT00730000110677.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi Q3SWZ3.
    KOi K13502.
    OMAi RMIQQRT.
    OrthoDBi EOG7X9G7R.
    TreeFami TF313763.

    Enzyme and pathway databases

    Reactomei REACT_216751. Clathrin derived vesicle budding.
    REACT_217718. Translocation of GLUT4 to the plasma membrane.
    REACT_220570. Disinhibition of SNARE formation.

    Miscellaneous databases

    NextBioi 20868628.

    Family and domain databases

    InterProi IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiSTX4_BOVIN
    AccessioniPrimary (citable) accession number: Q3SWZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3