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Protein

Syntaxin-4

Gene

STX4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-114516. Disinhibition of SNARE formation.
R-BTA-1236974. ER-Phagosome pathway.
R-BTA-421837. Clathrin derived vesicle budding.
R-BTA-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-4
Gene namesi
Name:STX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 275CytoplasmicSequence analysisAdd BLAST275
Transmembranei276 – 296Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini297ExtracellularSequence analysis1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828751 – 297Syntaxin-4Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei31PhosphothreonineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SWZ3.
PRIDEiQ3SWZ3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007523.

Interactioni

Subunit structurei

Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009899.

Structurei

3D structure databases

ProteinModelPortaliQ3SWZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 262t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 163Sequence analysisAdd BLAST121

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ3SWZ3.
KOiK13502.
OMAiYEMSNIN.
OrthoDBiEOG091G0EUK.
TreeFamiTF313763.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDRTHELRQ GDDSSDDEDK ERVALVVHPG TARLGSPDDE FFQKVRTIRQ
60 70 80 90 100
TIVKLENKVR ELEKQQVTIL ATPLPEESMK QDLQNLRDEI KQLGRDIRAQ
110 120 130 140 150
LKAIEPQKEE ADENYNSVNT RMRKTQHGVL SQQFVELINK CNLMQSEYRE
160 170 180 190 200
KNVERIRRQL KITNAGMVSD KELEQMLDSG QSEVFVSNIL KDTQVTRQAL
210 220 230 240 250
NEISARHSEI QQLERSIREL HEIFTFLATE VEMQGEMINR IEKNILSSAD
260 270 280 290
YVERGQEHVK VALENQKKAR KKKVFIAICL SITVLILVVI IVISTLV
Length:297
Mass (Da):34,400
Last modified:October 11, 2005 - v1
Checksum:i5CAE09860DD5C422
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104588 mRNA. Translation: AAI04589.1.
RefSeqiNP_001030236.1. NM_001035064.1.
UniGeneiBt.3076.

Genome annotation databases

EnsembliENSBTAT00000009899; ENSBTAP00000009899; ENSBTAG00000007523.
GeneIDi508675.
KEGGibta:508675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104588 mRNA. Translation: AAI04589.1.
RefSeqiNP_001030236.1. NM_001035064.1.
UniGeneiBt.3076.

3D structure databases

ProteinModelPortaliQ3SWZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009899.

Proteomic databases

PaxDbiQ3SWZ3.
PRIDEiQ3SWZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009899; ENSBTAP00000009899; ENSBTAG00000007523.
GeneIDi508675.
KEGGibta:508675.

Organism-specific databases

CTDi6810.

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ3SWZ3.
KOiK13502.
OMAiYEMSNIN.
OrthoDBiEOG091G0EUK.
TreeFamiTF313763.

Enzyme and pathway databases

ReactomeiR-BTA-114516. Disinhibition of SNARE formation.
R-BTA-1236974. ER-Phagosome pathway.
R-BTA-421837. Clathrin derived vesicle budding.
R-BTA-449147. Signaling by Interleukins.

Gene expression databases

BgeeiENSBTAG00000007523.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX4_BOVIN
AccessioniPrimary (citable) accession number: Q3SWZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: October 5, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.