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Q3SWZ3 (STX4_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-4
Gene names
Name:STX4
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones By similarity.

Subunit structure

Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 By similarity.

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Syntaxin-4
PRO_0000282875

Regions

Topological domain1 – 275275Cytoplasmic Potential
Transmembrane276 – 29621Helical; Anchor for type IV membrane protein; Potential
Topological domain2971Extracellular Potential
Domain200 – 26263t-SNARE coiled-coil homology
Coiled coil43 – 163121 Potential

Amino acid modifications

Modified residue141Phosphoserine By similarity
Modified residue151Phosphoserine By similarity
Modified residue1171Phosphoserine By similarity
Modified residue2481Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SWZ3 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 5CAE09860DD5C422

FASTA29734,400
        10         20         30         40         50         60 
MRDRTHELRQ GDDSSDDEDK ERVALVVHPG TARLGSPDDE FFQKVRTIRQ TIVKLENKVR 

        70         80         90        100        110        120 
ELEKQQVTIL ATPLPEESMK QDLQNLRDEI KQLGRDIRAQ LKAIEPQKEE ADENYNSVNT 

       130        140        150        160        170        180 
RMRKTQHGVL SQQFVELINK CNLMQSEYRE KNVERIRRQL KITNAGMVSD KELEQMLDSG 

       190        200        210        220        230        240 
QSEVFVSNIL KDTQVTRQAL NEISARHSEI QQLERSIREL HEIFTFLATE VEMQGEMINR 

       250        260        270        280        290 
IEKNILSSAD YVERGQEHVK VALENQKKAR KKKVFIAICL SITVLILVVI IVISTLV 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC104588 mRNA. Translation: AAI04589.1.
RefSeqNP_001030236.1. NM_001035064.1.
UniGeneBt.3076.

3D structure databases

ProteinModelPortalQ3SWZ3.
SMRQ3SWZ3. Positions 200-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000009899.

Proteomic databases

PRIDEQ3SWZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000009899; ENSBTAP00000009899; ENSBTAG00000007523.
GeneID508675.
KEGGbta:508675.

Organism-specific databases

CTD6810.

Phylogenomic databases

eggNOGCOG5074.
GeneTreeENSGT00730000110677.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidQ3SWZ3.
KOK13502.
OMALMQSEYR.
OrthoDBEOG7X9G7R.
TreeFamTF313763.

Family and domain databases

InterProIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868628.

Entry information

Entry nameSTX4_BOVIN
AccessionPrimary (citable) accession number: Q3SWZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families