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Q3SWZ3

- STX4_BOVIN

UniProt

Q3SWZ3 - STX4_BOVIN

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Protein

Syntaxin-4

Gene

STX4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity).By similarity

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. neurotransmitter transport Source: UniProtKB-KW
  3. SNARE complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_216751. Clathrin derived vesicle budding.
REACT_217718. Translocation of GLUT4 to the plasma membrane.
REACT_220570. Disinhibition of SNARE formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-4
Gene namesi
Name:STX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. caveola Source: AgBase
  3. cell surface Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. lateral loop Source: Ensembl
  7. myelin sheath adaxonal region Source: Ensembl
  8. perinuclear region of cytoplasm Source: Ensembl
  9. SNARE complex Source: UniProtKB
  10. specific granule Source: Ensembl
  11. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Syntaxin-4PRO_0000282875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ3SWZ3.

Interactioni

Subunit structurei

Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009899.

Structurei

3D structure databases

ProteinModelPortaliQ3SWZ3.
SMRiQ3SWZ3. Positions 200-255.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 275275CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini297 – 2971ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei276 – 29621Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 26263t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili43 – 163121Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiQ3SWZ3.
KOiK13502.
OMAiRMIQQRT.
OrthoDBiEOG7X9G7R.
TreeFamiTF313763.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWZ3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDRTHELRQ GDDSSDDEDK ERVALVVHPG TARLGSPDDE FFQKVRTIRQ
60 70 80 90 100
TIVKLENKVR ELEKQQVTIL ATPLPEESMK QDLQNLRDEI KQLGRDIRAQ
110 120 130 140 150
LKAIEPQKEE ADENYNSVNT RMRKTQHGVL SQQFVELINK CNLMQSEYRE
160 170 180 190 200
KNVERIRRQL KITNAGMVSD KELEQMLDSG QSEVFVSNIL KDTQVTRQAL
210 220 230 240 250
NEISARHSEI QQLERSIREL HEIFTFLATE VEMQGEMINR IEKNILSSAD
260 270 280 290
YVERGQEHVK VALENQKKAR KKKVFIAICL SITVLILVVI IVISTLV
Length:297
Mass (Da):34,400
Last modified:October 11, 2005 - v1
Checksum:i5CAE09860DD5C422
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104588 mRNA. Translation: AAI04589.1.
RefSeqiNP_001030236.1. NM_001035064.1.
UniGeneiBt.3076.

Genome annotation databases

EnsembliENSBTAT00000009899; ENSBTAP00000009899; ENSBTAG00000007523.
GeneIDi508675.
KEGGibta:508675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104588 mRNA. Translation: AAI04589.1 .
RefSeqi NP_001030236.1. NM_001035064.1.
UniGenei Bt.3076.

3D structure databases

ProteinModelPortali Q3SWZ3.
SMRi Q3SWZ3. Positions 200-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009899.

Proteomic databases

PRIDEi Q3SWZ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000009899 ; ENSBTAP00000009899 ; ENSBTAG00000007523 .
GeneIDi 508675.
KEGGi bta:508675.

Organism-specific databases

CTDi 6810.

Phylogenomic databases

eggNOGi COG5074.
GeneTreei ENSGT00760000119200.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi Q3SWZ3.
KOi K13502.
OMAi RMIQQRT.
OrthoDBi EOG7X9G7R.
TreeFami TF313763.

Enzyme and pathway databases

Reactomei REACT_216751. Clathrin derived vesicle budding.
REACT_217718. Translocation of GLUT4 to the plasma membrane.
REACT_220570. Disinhibition of SNARE formation.

Miscellaneous databases

NextBioi 20868628.

Family and domain databases

InterProi IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiSTX4_BOVIN
AccessioniPrimary (citable) accession number: Q3SWZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3