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Protein

Acyl-coenzyme A thioesterase 9, mitochondrial

Gene

ACOT9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-BTA-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 9, mitochondrial (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase 9
Alternative name(s):
Acyl-CoA thioester hydrolase 9
Gene namesi
Name:ACOT9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionBy similarityAdd
BLAST
Chaini22 – 437416Acyl-coenzyme A thioesterase 9, mitochondrialPRO_0000364186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SWX2.
PRIDEiQ3SWX2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011258.

Interactioni

Subunit structurei

Interacts with NYAP1, NYAP2 and MYO16.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014953.

Structurei

3D structure databases

ProteinModelPortaliQ3SWX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 207124HotDog ACOT-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini287 – 399113HotDog ACOT-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acyl coenzyme A hydrolase family.Curated
Contains 2 HotDog ACOT-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG2763. Eukaryota.
ENOG410XSYM. LUCA.
GeneTreeiENSGT00390000005330.
HOGENOMiHOG000188398.
HOVERGENiHBG004168.
InParanoidiQ3SWX2.
KOiK17361.
OMAiMFQLHGN.
OrthoDBiEOG091G06UC.
TreeFamiTF313352.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 2 hits.
PROSITEiPS51770. HOTDOG_ACOT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SWX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAALRLCT LSKGLLAPSR GLTQESQNPE NVFHIREVRD KLREIVGAST
60 70 80 90 100
NWRDHVKAME ERKLLHSFLA KSQKGLPPRT MKDSYIEVFL PLGSQPELRE
110 120 130 140 150
KYLTVQNTVR FGRILEDLDS LGVLICYMHN KIHSAKMSPL SIVTALVDKI
160 170 180 190 200
DMCKKNLSPE QDIKFSGHVS WVGKTSMEVK MHMFQLHGND FSPVLDATFV
210 220 230 240 250
MVARDSENKG PAFVNPLILE SPEEEELFQQ GELNKGRRVA FSSTSLLKMA
260 270 280 290 300
PTAEERTTIH EMFLNTLDPK TISFRSRVLP ANSVWMENSK LKSLDICHPQ
310 320 330 340 350
ERNIFNRIFG GFLMRKAYEL GWATACNFGG SRPFIVAVDD IMFQKPVEVG
360 370 380 390 400
SLLFLSAQVC FTQGNYIQVR VHSEVASLQD KEHMTTNVFH FTFMSEKEVP
410 420 430
LVFPRTYGES MLYLDGQRHF KSMSAPVTLK RNYVVEP
Length:437
Mass (Da):49,853
Last modified:October 11, 2005 - v1
Checksum:i945F868C0005FBAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030514 mRNA. Translation: ABQ12954.1.
BC104625 mRNA. Translation: AAI04626.1.
RefSeqiNP_001029732.1. NM_001034560.1.
UniGeneiBt.24384.

Genome annotation databases

EnsembliENSBTAT00000014953; ENSBTAP00000014953; ENSBTAG00000011258.
GeneIDi527845.
KEGGibta:527845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030514 mRNA. Translation: ABQ12954.1.
BC104625 mRNA. Translation: AAI04626.1.
RefSeqiNP_001029732.1. NM_001034560.1.
UniGeneiBt.24384.

3D structure databases

ProteinModelPortaliQ3SWX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014953.

Proteomic databases

PaxDbiQ3SWX2.
PRIDEiQ3SWX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014953; ENSBTAP00000014953; ENSBTAG00000011258.
GeneIDi527845.
KEGGibta:527845.

Organism-specific databases

CTDi23597.

Phylogenomic databases

eggNOGiKOG2763. Eukaryota.
ENOG410XSYM. LUCA.
GeneTreeiENSGT00390000005330.
HOGENOMiHOG000188398.
HOVERGENiHBG004168.
InParanoidiQ3SWX2.
KOiK17361.
OMAiMFQLHGN.
OrthoDBiEOG091G06UC.
TreeFamiTF313352.

Enzyme and pathway databases

ReactomeiR-BTA-75105. Fatty Acyl-CoA Biosynthesis.

Gene expression databases

BgeeiENSBTAG00000011258.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 2 hits.
PROSITEiPS51770. HOTDOG_ACOT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACOT9_BOVIN
AccessioniPrimary (citable) accession number: Q3SWX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.