Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl-coenzyme A thioesterase 9, mitochondrial

Gene

ACOT9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-BTA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 9, mitochondrial (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase 9
Alternative name(s):
Acyl-CoA thioester hydrolase 9
Gene namesi
Name:ACOT9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:25551 ACOT9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionBy similarityAdd BLAST21
ChainiPRO_000036418622 – 437Acyl-coenzyme A thioesterase 9, mitochondrialAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SWX2
PRIDEiQ3SWX2

Expressioni

Gene expression databases

BgeeiENSBTAG00000011258

Interactioni

Subunit structurei

Interacts with NYAP1, NYAP2 and MYO16.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014953

Structurei

3D structure databases

ProteinModelPortaliQ3SWX2
SMRiQ3SWX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 207HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST124
Domaini287 – 399HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the acyl coenzyme A hydrolase family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG2763 Eukaryota
ENOG410XSYM LUCA
GeneTreeiENSGT00390000005330
HOGENOMiHOG000188398
HOVERGENiHBG004168
InParanoidiQ3SWX2
KOiK17361
OMAiNSCLFTF
OrthoDBiEOG091G06UC
TreeFamiTF313352

Family and domain databases

InterProiView protein in InterPro
IPR033120 HOTDOG_ACOT
IPR029069 HotDog_dom_sf
SUPFAMiSSF54637 SSF54637, 2 hits
PROSITEiView protein in PROSITE
PS51770 HOTDOG_ACOT, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SWX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAALRLCT LSKGLLAPSR GLTQESQNPE NVFHIREVRD KLREIVGAST
60 70 80 90 100
NWRDHVKAME ERKLLHSFLA KSQKGLPPRT MKDSYIEVFL PLGSQPELRE
110 120 130 140 150
KYLTVQNTVR FGRILEDLDS LGVLICYMHN KIHSAKMSPL SIVTALVDKI
160 170 180 190 200
DMCKKNLSPE QDIKFSGHVS WVGKTSMEVK MHMFQLHGND FSPVLDATFV
210 220 230 240 250
MVARDSENKG PAFVNPLILE SPEEEELFQQ GELNKGRRVA FSSTSLLKMA
260 270 280 290 300
PTAEERTTIH EMFLNTLDPK TISFRSRVLP ANSVWMENSK LKSLDICHPQ
310 320 330 340 350
ERNIFNRIFG GFLMRKAYEL GWATACNFGG SRPFIVAVDD IMFQKPVEVG
360 370 380 390 400
SLLFLSAQVC FTQGNYIQVR VHSEVASLQD KEHMTTNVFH FTFMSEKEVP
410 420 430
LVFPRTYGES MLYLDGQRHF KSMSAPVTLK RNYVVEP
Length:437
Mass (Da):49,853
Last modified:October 11, 2005 - v1
Checksum:i945F868C0005FBAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030514 mRNA Translation: ABQ12954.1
BC104625 mRNA Translation: AAI04626.1
RefSeqiNP_001029732.1, NM_001034560.1
UniGeneiBt.24384

Genome annotation databases

EnsembliENSBTAT00000014953; ENSBTAP00000014953; ENSBTAG00000011258
GeneIDi527845
KEGGibta:527845

Similar proteinsi

Entry informationi

Entry nameiACOT9_BOVIN
AccessioniPrimary (citable) accession number: Q3SWX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health