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Protein

Protein canopy homolog 4

Gene

CNPY4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of the cell surface expression of TLR4.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 4
Gene namesi
Name:CNPY4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000031401721 – 239Protein canopy homolog 4Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 195By similarity
Disulfide bondi40 ↔ 183By similarity
Disulfide bondi93 ↔ 155By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ3SWX1.
PeptideAtlasiQ3SWX1.
PRIDEiQ3SWX1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007016.

Interactioni

Subunit structurei

Interacts with TLR4.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037026.

Family & Domainsi

Sequence similaritiesi

Belongs to the canopy family.Curated
Contains 1 saposin B-type domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4052. Eukaryota.
ENOG4111GVI. LUCA.
GeneTreeiENSGT00390000014072.
HOGENOMiHOG000030912.
HOVERGENiHBG107736.
InParanoidiQ3SWX1.
OMAiTISDWYF.
OrthoDBiEOG091G0QAJ.
TreeFamiTF318951.

Family and domain databases

InterProiIPR021852. DUF3456.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SWX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVRLGTLL FILTVYGAWA GTPKEEEDDT ERLPSKCEVC KLLSLELQEE
60 70 80 90 100
LSRTGRSREV LELGQVLDTG KRKRHIPYSV SETRLEEALE NLCERILDYS
110 120 130 140 150
VHAERKGSLR YAKGQSQTMA TLKGLVQKGV KVDLGIPLEL WDEPSVEVTF
160 170 180 190 200
LKKQCETMLE QFEDVVGDWY FHHQEQPLQH FLCEGHVLPA SETACLQETW
210 220 230
TGKEKITDGQ EKTEEEEQDQ EEEEMTNTPV HSQHDPEDL
Length:239
Mass (Da):27,369
Last modified:October 11, 2005 - v1
Checksum:i72713EF107EC91CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104626 mRNA. Translation: AAI04627.1.
RefSeqiNP_001029425.1. NM_001034253.2.
UniGeneiBt.20529.

Genome annotation databases

EnsembliENSBTAT00000037188; ENSBTAP00000037026; ENSBTAG00000007016.
GeneIDi505637.
KEGGibta:505637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104626 mRNA. Translation: AAI04627.1.
RefSeqiNP_001029425.1. NM_001034253.2.
UniGeneiBt.20529.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037026.

Proteomic databases

PaxDbiQ3SWX1.
PeptideAtlasiQ3SWX1.
PRIDEiQ3SWX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000037188; ENSBTAP00000037026; ENSBTAG00000007016.
GeneIDi505637.
KEGGibta:505637.

Organism-specific databases

CTDi245812.

Phylogenomic databases

eggNOGiKOG4052. Eukaryota.
ENOG4111GVI. LUCA.
GeneTreeiENSGT00390000014072.
HOGENOMiHOG000030912.
HOVERGENiHBG107736.
InParanoidiQ3SWX1.
OMAiTISDWYF.
OrthoDBiEOG091G0QAJ.
TreeFamiTF318951.

Gene expression databases

BgeeiENSBTAG00000007016.

Family and domain databases

InterProiIPR021852. DUF3456.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNPY4_BOVIN
AccessioniPrimary (citable) accession number: Q3SWX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.