Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3SWW8

- TSP4_BOVIN

UniProt

Q3SWW8 - TSP4_BOVIN

Protein

Thrombospondin-4

Gene

THBS4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: Ensembl

    GO - Biological processi

    1. behavioral response to pain Source: UniProtKB
    2. endothelial cell-cell adhesion Source: Ensembl
    3. myoblast migration Source: Ensembl
    4. negative regulation of angiogenesis Source: Ensembl
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of endothelial cell proliferation Source: Ensembl
    7. positive regulation of neutrophil chemotaxis Source: Ensembl
    8. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    9. regulation of tissue remodeling Source: UniProtKB
    10. response to endoplasmic reticulum stress Source: UniProtKB
    11. response to unfolded protein Source: UniProtKB-KW
    12. tissue remodeling Source: UniProtKB-KW

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Keywords - Biological processi

    Cell adhesion, Tissue remodeling, Unfolded protein response

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_204365. Signaling by PDGF.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thrombospondin-4
    Gene namesi
    Name:THBS4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10

    Subcellular locationi

    Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity. Secreted By similarity. Secretedextracellular space By similarity. Secretedextracellular spaceextracellular matrix By similarity

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. endoplasmic reticulum Source: UniProtKB
    3. extracellular matrix Source: UniProtKB
    4. extracellular space Source: UniProtKB
    5. sarcoplasmic reticulum Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 961938Thrombospondin-4PRO_0000283032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi258 – 258InterchainCurated
    Disulfide bondi261 – 261InterchainCurated
    Disulfide bondi290 ↔ 301PROSITE-ProRule annotation
    Disulfide bondi295 ↔ 310PROSITE-ProRule annotation
    Disulfide bondi313 ↔ 324PROSITE-ProRule annotation
    Disulfide bondi330 ↔ 341PROSITE-ProRule annotation
    Disulfide bondi335 ↔ 350PROSITE-ProRule annotation
    Disulfide bondi353 ↔ 377PROSITE-ProRule annotation
    Disulfide bondi383 ↔ 394PROSITE-ProRule annotation
    Disulfide bondi388 ↔ 403PROSITE-ProRule annotation
    Disulfide bondi406 ↔ 418PROSITE-ProRule annotation
    Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
    Disulfide bondi432 ↔ 448PROSITE-ProRule annotation
    Disulfide bondi450 ↔ 461PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 482PROSITE-ProRule annotation
    Disulfide bondi487 ↔ 507PROSITE-ProRule annotation
    Disulfide bondi523 ↔ 543PROSITE-ProRule annotation
    Disulfide bondi546 ↔ 566PROSITE-ProRule annotation
    Disulfide bondi582 ↔ 602PROSITE-ProRule annotation
    Disulfide bondi605 ↔ 625PROSITE-ProRule annotation
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi643 ↔ 663PROSITE-ProRule annotation
    Disulfide bondi683 ↔ 703PROSITE-ProRule annotation
    Disulfide bondi719 ↔ 940PROSITE-ProRule annotation
    Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ3SWW8.
    PRIDEiQ3SWW8.

    Interactioni

    Subunit structurei

    Homopentamer; disulfide-linked. Interacts with PTBP3 By similarity. Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation. Interacts with NOTCH1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000036460.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SWW8.
    SMRiQ3SWW8. Positions 218-262, 603-942.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 192169Laminin G-likeAdd
    BLAST
    Domaini286 – 32540EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini326 – 36338EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini379 – 41941EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 46243EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati463 – 49533TSP type-3 1Add
    BLAST
    Repeati496 – 53136TSP type-3 2Add
    BLAST
    Repeati532 – 55423TSP type-3 3Add
    BLAST
    Repeati555 – 59036TSP type-3 4Add
    BLAST
    Repeati591 – 61323TSP type-3 5Add
    BLAST
    Repeati614 – 65138TSP type-3 6Add
    BLAST
    Repeati652 – 69140TSP type-3 7Add
    BLAST
    Repeati692 – 72736TSP type-3 8Add
    BLAST
    Domaini731 – 945215TSP C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi562 – 5643Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 4 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
    Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00550000074507.
    HOGENOMiHOG000007542.
    HOVERGENiHBG000636.
    InParanoidiQ3SWW8.
    KOiK04659.
    OMAiAECQACG.
    OrthoDBiEOG76QFGD.
    TreeFamiTF324917.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view]
    PfamiPF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3SWW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAPRGATFL LLHLALQPWL GAGAQATPQV FDLLPSASQR LNPSVLQPIL    50
    TDPTLNELYV ISTFKLQSKS SATIFGLYSS ADHSKYFEFT VMGRLNKAIL 100
    RYLKNDGRIH LVVFNNLQLA DGRRHRLLLR LTNLHRGAGS VELFLDCTRV 150
    DSIHNLPRAF SGLAQSPEAV ELRTFQRKAH DSLEELKLVV RGSLIQVASL 200
    QDCFLQQSEP LATTNTGDFN RQFLGQMSQL NQLLGEVKDL LRQQVKETSF 250
    LRNTIAECQA CGPLSFQSPT PNTLMPVVPA ASPTPPVRRC DSNPCFRGVR 300
    CTDTRDGFQC GPCPEGYTGN GIVCSDVDEC RYHPCYPGVR CVNLAPGFRC 350
    DACPVGFTGP MMQGVGISFA KTNKQVCTDI DECRNGACVL NSICINTLGS 400
    YRCGPCKPGY IGDQMRGCKM ERNCRDPELN PCSVNAQCIE ERQGDVTCVC 450
    GVGWAGDGYI CGKDVDIDSY PDEELPCSAR NCKKDNCKYV PNSGQEDADR 500
    DGIGDACDDD ADGDGILNEQ DNCVLTHNVD QRNSDKDIFG DACDNCRNVL 550
    NNDQKDTDGD GKGDACDDDM DGDGIKNILD NCQKVPNSDQ EDRDGDGVGD 600
    ACDSCPEVSN PNQSDVDNDL VGDSCDTNQD SDGDGHQDST DNCPTVINSA 650
    QLDTDKDGIG DECDDDDDND GIPDLVPPGP DNCRLVPNPA QEDSNSDGVG 700
    DICEADFDQD QVIDRIDVCP ENAEVTLTDF RAYQTVVLDP EGDAQIDPNW 750
    VVLNQGMEIV QTMNSDPGLA VGYTAFNGVD FEGTFHVNTQ TDDDYAGFIF 800
    GYQDSSSFYV VMWKQTEQTY WQATPFRAVA EPGIQLKAVK SKTGPGEHLR 850
    NSLWHTGDTS DQVRLLWKDS RNVGWKDKVS YRWFLQHRPQ VGYIRVRFYE 900
    GSELVADSGV TIDTTMRGGR LGVFCFSQEN IIWSNLKYRC NDTIPEDFQE 950
    FQTQNFDRLD K 961
    Length:961
    Mass (Da):105,974
    Last modified:October 11, 2005 - v1
    Checksum:i5D51CA6752629A09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104630 mRNA. Translation: AAI04631.1.
    RefSeqiNP_001029900.1. NM_001034728.1.
    UniGeneiBt.11641.

    Genome annotation databases

    EnsembliENSBTAT00000036603; ENSBTAP00000036460; ENSBTAG00000012866.
    GeneIDi541281.
    KEGGibta:541281.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104630 mRNA. Translation: AAI04631.1 .
    RefSeqi NP_001029900.1. NM_001034728.1.
    UniGenei Bt.11641.

    3D structure databases

    ProteinModelPortali Q3SWW8.
    SMRi Q3SWW8. Positions 218-262, 603-942.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000036460.

    Proteomic databases

    PaxDbi Q3SWW8.
    PRIDEi Q3SWW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000036603 ; ENSBTAP00000036460 ; ENSBTAG00000012866 .
    GeneIDi 541281.
    KEGGi bta:541281.

    Organism-specific databases

    CTDi 7060.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00550000074507.
    HOGENOMi HOG000007542.
    HOVERGENi HBG000636.
    InParanoidi Q3SWW8.
    KOi K04659.
    OMAi AECQACG.
    OrthoDBi EOG76QFGD.
    TreeFami TF324917.

    Enzyme and pathway databases

    Reactomei REACT_204365. Signaling by PDGF.

    Miscellaneous databases

    NextBioi 20879115.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view ]
    Pfami PF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon.

    Entry informationi

    Entry nameiTSP4_BOVIN
    AccessioniPrimary (citable) accession number: Q3SWW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3