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Q3SWW8

- TSP4_BOVIN

UniProt

Q3SWW8 - TSP4_BOVIN

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Protein
Thrombospondin-4
Gene
THBS4
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. behavioral response to pain Source: UniProtKB
  2. endothelial cell-cell adhesion Source: Ensembl
  3. myoblast migration Source: Ensembl
  4. negative regulation of angiogenesis Source: Ensembl
  5. positive regulation of cell division Source: UniProtKB-KW
  6. positive regulation of endothelial cell proliferation Source: Ensembl
  7. positive regulation of neutrophil chemotaxis Source: Ensembl
  8. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  9. regulation of tissue remodeling Source: UniProtKB
  10. response to endoplasmic reticulum stress Source: UniProtKB
  11. response to unfolded protein Source: UniProtKB-KW
  12. tissue remodeling Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Biological processi

Cell adhesion, Tissue remodeling, Unfolded protein response

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_204365. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-4
Gene namesi
Name:THBS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 10

Subcellular locationi

Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity. Secreted By similarity. Secretedextracellular space By similarity. Secretedextracellular spaceextracellular matrix By similarity

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. endoplasmic reticulum Source: UniProtKB
  3. extracellular matrix Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. sarcoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 961938Thrombospondin-4
PRO_0000283032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi258 – 258Interchain Inferred
Disulfide bondi261 – 261Interchain Inferred
Disulfide bondi290 ↔ 301 By similarity
Disulfide bondi295 ↔ 310 By similarity
Disulfide bondi313 ↔ 324 By similarity
Disulfide bondi330 ↔ 341 By similarity
Disulfide bondi335 ↔ 350 By similarity
Disulfide bondi353 ↔ 377 By similarity
Disulfide bondi383 ↔ 394 By similarity
Disulfide bondi388 ↔ 403 By similarity
Disulfide bondi406 ↔ 418 By similarity
Disulfide bondi424 ↔ 438 By similarity
Disulfide bondi432 ↔ 448 By similarity
Disulfide bondi450 ↔ 461 By similarity
Disulfide bondi477 ↔ 482 By similarity
Disulfide bondi487 ↔ 507 By similarity
Disulfide bondi523 ↔ 543 By similarity
Disulfide bondi546 ↔ 566 By similarity
Disulfide bondi582 ↔ 602 By similarity
Disulfide bondi605 ↔ 625 By similarity
Glycosylationi612 – 6121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi643 ↔ 663 By similarity
Disulfide bondi683 ↔ 703 By similarity
Disulfide bondi719 ↔ 940 By similarity
Glycosylationi941 – 9411N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3SWW8.
PRIDEiQ3SWW8.

Interactioni

Subunit structurei

Homopentamer; disulfide-linked. Interacts with PTBP3 By similarity. Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation. Interacts with NOTCH1 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036460.

Structurei

3D structure databases

ProteinModelPortaliQ3SWW8.
SMRiQ3SWW8. Positions 218-262, 603-942.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 192169Laminin G-like
Add
BLAST
Domaini286 – 32540EGF-like 1
Add
BLAST
Domaini326 – 36338EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini379 – 41941EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini420 – 46243EGF-like 4
Add
BLAST
Repeati463 – 49533TSP type-3 1
Add
BLAST
Repeati496 – 53136TSP type-3 2
Add
BLAST
Repeati532 – 55423TSP type-3 3
Add
BLAST
Repeati555 – 59036TSP type-3 4
Add
BLAST
Repeati591 – 61323TSP type-3 5
Add
BLAST
Repeati614 – 65138TSP type-3 6
Add
BLAST
Repeati652 – 69140TSP type-3 7
Add
BLAST
Repeati692 – 72736TSP type-3 8
Add
BLAST
Domaini731 – 945215TSP C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi562 – 5643Cell attachment site Reviewed prediction

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 4 EGF-like domains.
Contains 8 TSP type-3 repeats.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00550000074507.
HOGENOMiHOG000007542.
HOVERGENiHBG000636.
InParanoidiQ3SWW8.
KOiK04659.
OMAiAECQACG.
OrthoDBiEOG76QFGD.
TreeFamiTF324917.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PfamiPF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SWW8-1 [UniParc]FASTAAdd to Basket

« Hide

MLAPRGATFL LLHLALQPWL GAGAQATPQV FDLLPSASQR LNPSVLQPIL    50
TDPTLNELYV ISTFKLQSKS SATIFGLYSS ADHSKYFEFT VMGRLNKAIL 100
RYLKNDGRIH LVVFNNLQLA DGRRHRLLLR LTNLHRGAGS VELFLDCTRV 150
DSIHNLPRAF SGLAQSPEAV ELRTFQRKAH DSLEELKLVV RGSLIQVASL 200
QDCFLQQSEP LATTNTGDFN RQFLGQMSQL NQLLGEVKDL LRQQVKETSF 250
LRNTIAECQA CGPLSFQSPT PNTLMPVVPA ASPTPPVRRC DSNPCFRGVR 300
CTDTRDGFQC GPCPEGYTGN GIVCSDVDEC RYHPCYPGVR CVNLAPGFRC 350
DACPVGFTGP MMQGVGISFA KTNKQVCTDI DECRNGACVL NSICINTLGS 400
YRCGPCKPGY IGDQMRGCKM ERNCRDPELN PCSVNAQCIE ERQGDVTCVC 450
GVGWAGDGYI CGKDVDIDSY PDEELPCSAR NCKKDNCKYV PNSGQEDADR 500
DGIGDACDDD ADGDGILNEQ DNCVLTHNVD QRNSDKDIFG DACDNCRNVL 550
NNDQKDTDGD GKGDACDDDM DGDGIKNILD NCQKVPNSDQ EDRDGDGVGD 600
ACDSCPEVSN PNQSDVDNDL VGDSCDTNQD SDGDGHQDST DNCPTVINSA 650
QLDTDKDGIG DECDDDDDND GIPDLVPPGP DNCRLVPNPA QEDSNSDGVG 700
DICEADFDQD QVIDRIDVCP ENAEVTLTDF RAYQTVVLDP EGDAQIDPNW 750
VVLNQGMEIV QTMNSDPGLA VGYTAFNGVD FEGTFHVNTQ TDDDYAGFIF 800
GYQDSSSFYV VMWKQTEQTY WQATPFRAVA EPGIQLKAVK SKTGPGEHLR 850
NSLWHTGDTS DQVRLLWKDS RNVGWKDKVS YRWFLQHRPQ VGYIRVRFYE 900
GSELVADSGV TIDTTMRGGR LGVFCFSQEN IIWSNLKYRC NDTIPEDFQE 950
FQTQNFDRLD K 961
Length:961
Mass (Da):105,974
Last modified:October 11, 2005 - v1
Checksum:i5D51CA6752629A09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104630 mRNA. Translation: AAI04631.1.
RefSeqiNP_001029900.1. NM_001034728.1.
UniGeneiBt.11641.

Genome annotation databases

EnsembliENSBTAT00000036603; ENSBTAP00000036460; ENSBTAG00000012866.
GeneIDi541281.
KEGGibta:541281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104630 mRNA. Translation: AAI04631.1 .
RefSeqi NP_001029900.1. NM_001034728.1.
UniGenei Bt.11641.

3D structure databases

ProteinModelPortali Q3SWW8.
SMRi Q3SWW8. Positions 218-262, 603-942.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000036460.

Proteomic databases

PaxDbi Q3SWW8.
PRIDEi Q3SWW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000036603 ; ENSBTAP00000036460 ; ENSBTAG00000012866 .
GeneIDi 541281.
KEGGi bta:541281.

Organism-specific databases

CTDi 7060.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00550000074507.
HOGENOMi HOG000007542.
HOVERGENi HBG000636.
InParanoidi Q3SWW8.
KOi K04659.
OMAi AECQACG.
OrthoDBi EOG76QFGD.
TreeFami TF324917.

Enzyme and pathway databases

Reactomei REACT_204365. Signaling by PDGF.

Miscellaneous databases

NextBioi 20879115.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view ]
Pfami PF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiTSP4_BOVIN
AccessioniPrimary (citable) accession number: Q3SWW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi