Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3SWW8

- TSP4_BOVIN

UniProt

Q3SWW8 - TSP4_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thrombospondin-4

Gene

THBS4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: Ensembl

GO - Biological processi

  1. behavioral response to pain Source: UniProtKB
  2. endothelial cell-cell adhesion Source: Ensembl
  3. myoblast migration Source: Ensembl
  4. negative regulation of angiogenesis Source: Ensembl
  5. positive regulation of cell division Source: UniProtKB-KW
  6. positive regulation of endothelial cell proliferation Source: Ensembl
  7. positive regulation of neutrophil chemotaxis Source: Ensembl
  8. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  9. regulation of tissue remodeling Source: UniProtKB
  10. response to endoplasmic reticulum stress Source: UniProtKB
  11. response to unfolded protein Source: UniProtKB-KW
  12. tissue remodeling Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Biological processi

Cell adhesion, Tissue remodeling, Unfolded protein response

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_204365. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-4
Gene namesi
Name:THBS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 10

Subcellular locationi

Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity. Secreted By similarity. Secretedextracellular space By similarity. Secretedextracellular spaceextracellular matrix By similarity

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. endoplasmic reticulum Source: UniProtKB
  3. extracellular matrix Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. sarcoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 961938Thrombospondin-4PRO_0000283032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi258 – 258InterchainCurated
Disulfide bondi261 – 261InterchainCurated
Disulfide bondi290 ↔ 301PROSITE-ProRule annotation
Disulfide bondi295 ↔ 310PROSITE-ProRule annotation
Disulfide bondi313 ↔ 324PROSITE-ProRule annotation
Disulfide bondi330 ↔ 341PROSITE-ProRule annotation
Disulfide bondi335 ↔ 350PROSITE-ProRule annotation
Disulfide bondi353 ↔ 377PROSITE-ProRule annotation
Disulfide bondi383 ↔ 394PROSITE-ProRule annotation
Disulfide bondi388 ↔ 403PROSITE-ProRule annotation
Disulfide bondi406 ↔ 418PROSITE-ProRule annotation
Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
Disulfide bondi432 ↔ 448PROSITE-ProRule annotation
Disulfide bondi450 ↔ 461PROSITE-ProRule annotation
Disulfide bondi477 ↔ 482PROSITE-ProRule annotation
Disulfide bondi487 ↔ 507PROSITE-ProRule annotation
Disulfide bondi523 ↔ 543PROSITE-ProRule annotation
Disulfide bondi546 ↔ 566PROSITE-ProRule annotation
Disulfide bondi582 ↔ 602PROSITE-ProRule annotation
Disulfide bondi605 ↔ 625PROSITE-ProRule annotation
Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi643 ↔ 663PROSITE-ProRule annotation
Disulfide bondi683 ↔ 703PROSITE-ProRule annotation
Disulfide bondi719 ↔ 940PROSITE-ProRule annotation
Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3SWW8.
PRIDEiQ3SWW8.

Interactioni

Subunit structurei

Homopentamer; disulfide-linked. Interacts with PTBP3 (By similarity). Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation. Interacts with NOTCH1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036460.

Structurei

3D structure databases

ProteinModelPortaliQ3SWW8.
SMRiQ3SWW8. Positions 218-262, 603-942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 192169Laminin G-likeAdd
BLAST
Domaini286 – 32540EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini326 – 36338EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini379 – 41941EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini420 – 46243EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Repeati463 – 49533TSP type-3 1Add
BLAST
Repeati496 – 53136TSP type-3 2Add
BLAST
Repeati532 – 55423TSP type-3 3Add
BLAST
Repeati555 – 59036TSP type-3 4Add
BLAST
Repeati591 – 61323TSP type-3 5Add
BLAST
Repeati614 – 65138TSP type-3 6Add
BLAST
Repeati652 – 69140TSP type-3 7Add
BLAST
Repeati692 – 72736TSP type-3 8Add
BLAST
Domaini731 – 945215TSP C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi562 – 5643Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00550000074507.
HOGENOMiHOG000007542.
HOVERGENiHBG000636.
InParanoidiQ3SWW8.
KOiK04659.
OMAiAECQACG.
OrthoDBiEOG76QFGD.
TreeFamiTF324917.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PfamiPF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SWW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAPRGATFL LLHLALQPWL GAGAQATPQV FDLLPSASQR LNPSVLQPIL
60 70 80 90 100
TDPTLNELYV ISTFKLQSKS SATIFGLYSS ADHSKYFEFT VMGRLNKAIL
110 120 130 140 150
RYLKNDGRIH LVVFNNLQLA DGRRHRLLLR LTNLHRGAGS VELFLDCTRV
160 170 180 190 200
DSIHNLPRAF SGLAQSPEAV ELRTFQRKAH DSLEELKLVV RGSLIQVASL
210 220 230 240 250
QDCFLQQSEP LATTNTGDFN RQFLGQMSQL NQLLGEVKDL LRQQVKETSF
260 270 280 290 300
LRNTIAECQA CGPLSFQSPT PNTLMPVVPA ASPTPPVRRC DSNPCFRGVR
310 320 330 340 350
CTDTRDGFQC GPCPEGYTGN GIVCSDVDEC RYHPCYPGVR CVNLAPGFRC
360 370 380 390 400
DACPVGFTGP MMQGVGISFA KTNKQVCTDI DECRNGACVL NSICINTLGS
410 420 430 440 450
YRCGPCKPGY IGDQMRGCKM ERNCRDPELN PCSVNAQCIE ERQGDVTCVC
460 470 480 490 500
GVGWAGDGYI CGKDVDIDSY PDEELPCSAR NCKKDNCKYV PNSGQEDADR
510 520 530 540 550
DGIGDACDDD ADGDGILNEQ DNCVLTHNVD QRNSDKDIFG DACDNCRNVL
560 570 580 590 600
NNDQKDTDGD GKGDACDDDM DGDGIKNILD NCQKVPNSDQ EDRDGDGVGD
610 620 630 640 650
ACDSCPEVSN PNQSDVDNDL VGDSCDTNQD SDGDGHQDST DNCPTVINSA
660 670 680 690 700
QLDTDKDGIG DECDDDDDND GIPDLVPPGP DNCRLVPNPA QEDSNSDGVG
710 720 730 740 750
DICEADFDQD QVIDRIDVCP ENAEVTLTDF RAYQTVVLDP EGDAQIDPNW
760 770 780 790 800
VVLNQGMEIV QTMNSDPGLA VGYTAFNGVD FEGTFHVNTQ TDDDYAGFIF
810 820 830 840 850
GYQDSSSFYV VMWKQTEQTY WQATPFRAVA EPGIQLKAVK SKTGPGEHLR
860 870 880 890 900
NSLWHTGDTS DQVRLLWKDS RNVGWKDKVS YRWFLQHRPQ VGYIRVRFYE
910 920 930 940 950
GSELVADSGV TIDTTMRGGR LGVFCFSQEN IIWSNLKYRC NDTIPEDFQE
960
FQTQNFDRLD K
Length:961
Mass (Da):105,974
Last modified:October 11, 2005 - v1
Checksum:i5D51CA6752629A09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104630 mRNA. Translation: AAI04631.1.
RefSeqiNP_001029900.1. NM_001034728.1.
UniGeneiBt.11641.

Genome annotation databases

EnsembliENSBTAT00000036603; ENSBTAP00000036460; ENSBTAG00000012866.
GeneIDi541281.
KEGGibta:541281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104630 mRNA. Translation: AAI04631.1 .
RefSeqi NP_001029900.1. NM_001034728.1.
UniGenei Bt.11641.

3D structure databases

ProteinModelPortali Q3SWW8.
SMRi Q3SWW8. Positions 218-262, 603-942.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000036460.

Proteomic databases

PaxDbi Q3SWW8.
PRIDEi Q3SWW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000036603 ; ENSBTAP00000036460 ; ENSBTAG00000012866 .
GeneIDi 541281.
KEGGi bta:541281.

Organism-specific databases

CTDi 7060.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00550000074507.
HOGENOMi HOG000007542.
HOVERGENi HBG000636.
InParanoidi Q3SWW8.
KOi K04659.
OMAi AECQACG.
OrthoDBi EOG76QFGD.
TreeFami TF324917.

Enzyme and pathway databases

Reactomei REACT_204365. Signaling by PDGF.

Miscellaneous databases

NextBioi 20879115.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view ]
Pfami PF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiTSP4_BOVIN
AccessioniPrimary (citable) accession number: Q3SWW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3