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Protein

Heterogeneous nuclear ribonucleoprotein D-like

Gene

Hnrnpdl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein D-like
Short name:
hnRNP D-like
Short name:
hnRNP DL
Gene namesi
Name:Hnrnpdl
Synonyms:Hnrpdl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1309950. Hnrnpdl.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Heterogeneous nuclear ribonucleoprotein D-likePRO_0000287241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei64 – 641N6-methyllysineBy similarity
Modified residuei119 – 1191N6-acetyllysineBy similarity
Modified residuei144 – 1441PhosphoserineCombined sources
Modified residuei228 – 2281Dimethylated arginine; alternateBy similarity
Modified residuei228 – 2281Omega-N-methylarginine; alternateBy similarity
Modified residuei310 – 3101Dimethylated arginine; alternateBy similarity
Modified residuei310 – 3101Omega-N-methylated arginine; alternateBy similarity

Post-translational modificationi

Dimethylation of Arg-310 is probably of the asymmetric type.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ3SWU3.
PRIDEiQ3SWU3.

PTM databases

iPTMnetiQ3SWU3.
PhosphoSiteiQ3SWU3.

Expressioni

Gene expression databases

ExpressionAtlasiQ3SWU3. baseline and differential.

Interactioni

Subunit structurei

Interacts with TNPO1 and ZNF148.By similarity

Protein-protein interaction databases

BioGridi258094. 1 interaction.
STRINGi10116.ENSRNOP00000003106.

Structurei

3D structure databases

ProteinModelPortaliQ3SWU3.
SMRiQ3SWU3. Positions 52-126, 136-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 13383RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 21580RRM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni245 – 32278Necessary for interaction with TNPO1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2246Poly-Gln
Compositional biasi226 – 31388Gly-richAdd
BLAST
Compositional biasi256 – 29843Tyr-richAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOVERGENiHBG002295.
InParanoidiQ3SWU3.
KOiK13044.
OMAiGPGYTDY.
OrthoDBiEOG715Q6V.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGTARSALP LPQSPARALR PSGAARAAPS LSPSRFSACP LDPSSFPTSG
60 70 80 90 100
NKMFIGGLSW DTSKKDLTEY LSRFGEVVDC TIKTDPVTGR SRGFGFVLFK
110 120 130 140 150
DAASVDKVLE LKEHKLDGKL IDPKRAKALK GKEPPKKVFV GGLSPDTSEE
160 170 180 190 200
QIKEYFGAFG EIENIELPMD TKTNERRGFC FITYTDEEPV KKLLESRYHQ
210 220 230 240 250
IGSGKCEIKV AQPKEVYRQQ QQQQKGGRGA AAGGRGGARG RGRGQGQNWN
260 270 280 290 300
QGFNNYYDQG YGNYNSAYGD ESYSGYGGYD YTGYNYGSYG YGQGYTDYSG
310 320
QQSTYGKASR GGGNHQNNYQ PY
Length:322
Mass (Da):35,294
Last modified:October 11, 2005 - v1
Checksum:i42DE123DDC74A9AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104683 mRNA. Translation: AAI04684.1.
RefSeqiNP_001028868.1. NM_001033696.1.
UniGeneiRn.102146.

Genome annotation databases

EnsembliENSRNOT00000003106; ENSRNOP00000003106; ENSRNOG00000002270.
GeneIDi305178.
KEGGirno:305178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104683 mRNA. Translation: AAI04684.1.
RefSeqiNP_001028868.1. NM_001033696.1.
UniGeneiRn.102146.

3D structure databases

ProteinModelPortaliQ3SWU3.
SMRiQ3SWU3. Positions 52-126, 136-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi258094. 1 interaction.
STRINGi10116.ENSRNOP00000003106.

PTM databases

iPTMnetiQ3SWU3.
PhosphoSiteiQ3SWU3.

Proteomic databases

PaxDbiQ3SWU3.
PRIDEiQ3SWU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003106; ENSRNOP00000003106; ENSRNOG00000002270.
GeneIDi305178.
KEGGirno:305178.

Organism-specific databases

CTDi9987.
RGDi1309950. Hnrnpdl.

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOVERGENiHBG002295.
InParanoidiQ3SWU3.
KOiK13044.
OMAiGPGYTDY.
OrthoDBiEOG715Q6V.

Miscellaneous databases

NextBioi654187.
PROiQ3SWU3.

Gene expression databases

ExpressionAtlasiQ3SWU3. baseline and differential.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHNRDL_RAT
AccessioniPrimary (citable) accession number: Q3SWU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: February 17, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.