Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3SWT6

- PPE1_RAT

UniProt

Q3SWT6 - PPE1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein phosphatase with EF-hands 1

Gene

Ppef1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May have a role in the recovery or adaptation response of photoreceptors. May have a role in development By similarity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity
Magnesium.By similarity

Enzyme regulationi

Activated by calcium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi173 – 1731Manganese 1By similarity
Metal bindingi175 – 1751Manganese 1By similarity
Metal bindingi202 – 2021Manganese 1By similarity
Metal bindingi202 – 2021Manganese 2By similarity
Metal bindingi234 – 2341Manganese 2By similarity
Active sitei235 – 2351Proton donorBy similarity
Metal bindingi286 – 2861Manganese 2By similarity
Metal bindingi393 – 3931Manganese 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi569 – 580121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi609 – 620122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. manganese ion binding Source: InterPro
  4. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. detection of stimulus involved in sensory perception Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase with EF-hands 1 (EC:3.1.3.16)
Short name:
PPEF-1
Gene namesi
Name:Ppef1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1562772. Ppef1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Serine/threonine-protein phosphatase with EF-hands 1PRO_0000294517Add
BLAST

Proteomic databases

PaxDbiQ3SWT6.
PRIDEiQ3SWT6.

Expressioni

Gene expression databases

GenevestigatoriQ3SWT6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055729.

Structurei

3D structure databases

ProteinModelPortaliQ3SWT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 4530IQAdd
BLAST
Domaini473 – 50836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini556 – 59136EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini596 – 63136EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 445324CatalyticBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the PPP phosphatase family.Curated
Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 1 IQ domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000006820.
HOVERGENiHBG008238.
InParanoidiQ3SWT6.
KOiK13807.
PhylomeDBiQ3SWT6.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view]
PIRSFiPIRSF000912. PPEF. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 2 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCGSSSKKG KKSEKVVRAA LIIQNWYRRY RARLSARQHY ALAIFQSIEY
60 70 80 90 100
ADEQGQMQLS SFFSFMLENY TNTHKEDSAL VSRLFENTRL ESKDREEYVG
110 120 130 140 150
LIDVPDSYDG PRLQFPLTFT DINLLLQAFK QQQTLHAHYV LEVLFEARKI
160 170 180 190 200
LKQMPNFTRI QTFPAKEITI CGDLHGKLDD LMLIFYKNGL PSEKNPYVFN
210 220 230 240 250
GDFVDRGNNS MEILMILLVS FLVYPTDLHL NRGNHEDFMM NLRYGFTKEI
260 270 280 290 300
LQKYKLHGKK ILQVLEELYT WLPIGTIIDN EILVIHGGIS ESTDLNILQQ
310 320 330 340 350
LQRNKMKSVL MPPMSTNQEC NIKKNKAGPS EQSASEQLTK LEWEQIIDLL
360 370 380 390 400
WSDPRGKKGC YPNTSRGGGC YFGPDVTSKV LNKNQLKMVI RSHECKPDGY
410 420 430 440 450
EICHDGKVIT VFSASNYYEE GSNRGAYIRL SYGTSPQFFQ YQVTSTSCLN
460 470 480 490 500
PLYQRVNAME FSAFRILKER MIARKTDLIN AFELRDHSRT GKISLAQWAF
510 520 530 540 550
SMESILGLNL PWRSLSSHLV STDSSGSVDY MSSFDDIHIE KPMKDMKSDL
560 570 580 590 600
IETMYRYRSD LKIIFNIIDT DQSGLISMDE FRTMWKLFNA HYKVHIDDSQ
610 620 630 640
IDELASTMDS NKDGNIDFNE FLRAFYVVHK YETPESPLNK
Length:640
Mass (Da):73,966
Last modified:October 11, 2005 - v1
Checksum:iBC841AF1E11F031C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104696 mRNA. Translation: AAI04697.1.
RefSeqiNP_001030107.1. NM_001034935.1.
UniGeneiRn.103108.

Genome annotation databases

GeneIDi317498.
KEGGirno:317498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104696 mRNA. Translation: AAI04697.1 .
RefSeqi NP_001030107.1. NM_001034935.1.
UniGenei Rn.103108.

3D structure databases

ProteinModelPortali Q3SWT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000055729.

Proteomic databases

PaxDbi Q3SWT6.
PRIDEi Q3SWT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 317498.
KEGGi rno:317498.

Organism-specific databases

CTDi 5475.
RGDi 1562772. Ppef1.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000006820.
HOVERGENi HBG008238.
InParanoidi Q3SWT6.
KOi K13807.
PhylomeDBi Q3SWT6.

Miscellaneous databases

NextBioi 671879.
PROi Q3SWT6.

Gene expression databases

Genevestigatori Q3SWT6.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
3.60.21.10. 2 hits.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view ]
PIRSFi PIRSF000912. PPEF. 1 hit.
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00054. EFh. 2 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 2 hits.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPPE1_RAT
AccessioniPrimary (citable) accession number: Q3SWT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2005
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3