Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3SWT6 (PPE1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase with EF-hands 1

Short name=PPEF-1
EC=3.1.3.16
Gene names
Name:Ppef1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in the recovery or adaptation response of photoreceptors. May have a role in development By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Magnesium By similarity.

Enzyme regulation

Activated by calcium By similarity.

Sequence similarities

Belongs to the PPP phosphatase family.

Contains 3 EF-hand domains.

Contains 1 IQ domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Serine/threonine-protein phosphatase with EF-hands 1
PRO_0000294517

Regions

Domain16 – 4530IQ
Domain473 – 50836EF-hand 1
Domain556 – 59136EF-hand 2
Domain596 – 63136EF-hand 3
Calcium binding569 – 580121 Potential
Calcium binding609 – 620122 Potential
Region122 – 445324Catalytic By similarity

Sites

Active site2351Proton donor By similarity
Metal binding1731Manganese 1 By similarity
Metal binding1751Manganese 1 By similarity
Metal binding2021Manganese 1 By similarity
Metal binding2021Manganese 2 By similarity
Metal binding2341Manganese 2 By similarity
Metal binding2861Manganese 2 By similarity
Metal binding3931Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SWT6 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: BC841AF1E11F031C

FASTA64073,966
        10         20         30         40         50         60 
MGCGSSSKKG KKSEKVVRAA LIIQNWYRRY RARLSARQHY ALAIFQSIEY ADEQGQMQLS 

        70         80         90        100        110        120 
SFFSFMLENY TNTHKEDSAL VSRLFENTRL ESKDREEYVG LIDVPDSYDG PRLQFPLTFT 

       130        140        150        160        170        180 
DINLLLQAFK QQQTLHAHYV LEVLFEARKI LKQMPNFTRI QTFPAKEITI CGDLHGKLDD 

       190        200        210        220        230        240 
LMLIFYKNGL PSEKNPYVFN GDFVDRGNNS MEILMILLVS FLVYPTDLHL NRGNHEDFMM 

       250        260        270        280        290        300 
NLRYGFTKEI LQKYKLHGKK ILQVLEELYT WLPIGTIIDN EILVIHGGIS ESTDLNILQQ 

       310        320        330        340        350        360 
LQRNKMKSVL MPPMSTNQEC NIKKNKAGPS EQSASEQLTK LEWEQIIDLL WSDPRGKKGC 

       370        380        390        400        410        420 
YPNTSRGGGC YFGPDVTSKV LNKNQLKMVI RSHECKPDGY EICHDGKVIT VFSASNYYEE 

       430        440        450        460        470        480 
GSNRGAYIRL SYGTSPQFFQ YQVTSTSCLN PLYQRVNAME FSAFRILKER MIARKTDLIN 

       490        500        510        520        530        540 
AFELRDHSRT GKISLAQWAF SMESILGLNL PWRSLSSHLV STDSSGSVDY MSSFDDIHIE 

       550        560        570        580        590        600 
KPMKDMKSDL IETMYRYRSD LKIIFNIIDT DQSGLISMDE FRTMWKLFNA HYKVHIDDSQ 

       610        620        630        640 
IDELASTMDS NKDGNIDFNE FLRAFYVVHK YETPESPLNK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC104696 mRNA. Translation: AAI04697.1.
RefSeqNP_001030107.1. NM_001034935.1.
UniGeneRn.103108.

3D structure databases

ProteinModelPortalQ3SWT6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000055729.

Proteomic databases

PaxDbQ3SWT6.
PRIDEQ3SWT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID317498.
KEGGrno:317498.

Organism-specific databases

CTD5475.
RGD1562772. Ppef1.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000006820.
HOVERGENHBG008238.
InParanoidQ3SWT6.
KOK13807.
PhylomeDBQ3SWT6.

Gene expression databases

GenevestigatorQ3SWT6.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
3.60.21.10. 2 hits.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view]
PIRSFPIRSF000912. PPEF. 1 hit.
PRINTSPR00114. STPHPHTASE.
SMARTSM00054. EFh. 2 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 2 hits.
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio671879.
PROQ3SWT6.

Entry information

Entry namePPE1_RAT
AccessionPrimary (citable) accession number: Q3SWT6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families