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Q3SWT6

- PPE1_RAT

UniProt

Q3SWT6 - PPE1_RAT

Protein

Serine/threonine-protein phosphatase with EF-hands 1

Gene

Ppef1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    May have a role in the recovery or adaptation response of photoreceptors. May have a role in development By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity
    Magnesium.By similarity

    Enzyme regulationi

    Activated by calcium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi173 – 1731Manganese 1By similarity
    Metal bindingi175 – 1751Manganese 1By similarity
    Metal bindingi202 – 2021Manganese 1By similarity
    Metal bindingi202 – 2021Manganese 2By similarity
    Metal bindingi234 – 2341Manganese 2By similarity
    Active sitei235 – 2351Proton donorBy similarity
    Metal bindingi286 – 2861Manganese 2By similarity
    Metal bindingi393 – 3931Manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi569 – 580121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi609 – 620122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. manganese ion binding Source: InterPro
    4. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. detection of stimulus involved in sensory perception Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase with EF-hands 1 (EC:3.1.3.16)
    Short name:
    PPEF-1
    Gene namesi
    Name:Ppef1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1562772. Ppef1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640Serine/threonine-protein phosphatase with EF-hands 1PRO_0000294517Add
    BLAST

    Proteomic databases

    PaxDbiQ3SWT6.
    PRIDEiQ3SWT6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3SWT6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000055729.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SWT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 4530IQAdd
    BLAST
    Domaini473 – 50836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini556 – 59136EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini596 – 63136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni122 – 445324CatalyticBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PPP phosphatase family.Curated
    Contains 3 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 IQ domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000006820.
    HOVERGENiHBG008238.
    InParanoidiQ3SWT6.
    KOiK13807.
    PhylomeDBiQ3SWT6.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    3.60.21.10. 2 hits.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR029052. Metallo-depent_PP-like.
    IPR013235. PPP_dom.
    IPR012008. Ser/Thr-Pase_EF-hand_contain.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    PF00149. Metallophos. 1 hit.
    PF08321. PPP5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000912. PPEF. 1 hit.
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00054. EFh. 2 hits.
    SM00015. IQ. 1 hit.
    SM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 2 hits.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3SWT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCGSSSKKG KKSEKVVRAA LIIQNWYRRY RARLSARQHY ALAIFQSIEY    50
    ADEQGQMQLS SFFSFMLENY TNTHKEDSAL VSRLFENTRL ESKDREEYVG 100
    LIDVPDSYDG PRLQFPLTFT DINLLLQAFK QQQTLHAHYV LEVLFEARKI 150
    LKQMPNFTRI QTFPAKEITI CGDLHGKLDD LMLIFYKNGL PSEKNPYVFN 200
    GDFVDRGNNS MEILMILLVS FLVYPTDLHL NRGNHEDFMM NLRYGFTKEI 250
    LQKYKLHGKK ILQVLEELYT WLPIGTIIDN EILVIHGGIS ESTDLNILQQ 300
    LQRNKMKSVL MPPMSTNQEC NIKKNKAGPS EQSASEQLTK LEWEQIIDLL 350
    WSDPRGKKGC YPNTSRGGGC YFGPDVTSKV LNKNQLKMVI RSHECKPDGY 400
    EICHDGKVIT VFSASNYYEE GSNRGAYIRL SYGTSPQFFQ YQVTSTSCLN 450
    PLYQRVNAME FSAFRILKER MIARKTDLIN AFELRDHSRT GKISLAQWAF 500
    SMESILGLNL PWRSLSSHLV STDSSGSVDY MSSFDDIHIE KPMKDMKSDL 550
    IETMYRYRSD LKIIFNIIDT DQSGLISMDE FRTMWKLFNA HYKVHIDDSQ 600
    IDELASTMDS NKDGNIDFNE FLRAFYVVHK YETPESPLNK 640
    Length:640
    Mass (Da):73,966
    Last modified:October 11, 2005 - v1
    Checksum:iBC841AF1E11F031C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104696 mRNA. Translation: AAI04697.1.
    RefSeqiNP_001030107.1. NM_001034935.1.
    UniGeneiRn.103108.

    Genome annotation databases

    GeneIDi317498.
    KEGGirno:317498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104696 mRNA. Translation: AAI04697.1 .
    RefSeqi NP_001030107.1. NM_001034935.1.
    UniGenei Rn.103108.

    3D structure databases

    ProteinModelPortali Q3SWT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000055729.

    Proteomic databases

    PaxDbi Q3SWT6.
    PRIDEi Q3SWT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 317498.
    KEGGi rno:317498.

    Organism-specific databases

    CTDi 5475.
    RGDi 1562772. Ppef1.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000006820.
    HOVERGENi HBG008238.
    InParanoidi Q3SWT6.
    KOi K13807.
    PhylomeDBi Q3SWT6.

    Miscellaneous databases

    NextBioi 671879.
    PROi Q3SWT6.

    Gene expression databases

    Genevestigatori Q3SWT6.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    3.60.21.10. 2 hits.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR029052. Metallo-depent_PP-like.
    IPR013235. PPP_dom.
    IPR012008. Ser/Thr-Pase_EF-hand_contain.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    PF00149. Metallophos. 1 hit.
    PF08321. PPP5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000912. PPEF. 1 hit.
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00054. EFh. 2 hits.
    SM00015. IQ. 1 hit.
    SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 2 hits.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiPPE1_RAT
    AccessioniPrimary (citable) accession number: Q3SWT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3