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Q3SWT6

- PPE1_RAT

UniProt

Q3SWT6 - PPE1_RAT

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Protein

Serine/threonine-protein phosphatase with EF-hands 1

Gene
Ppef1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May have a role in the recovery or adaptation response of photoreceptors. May have a role in development By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.
Magnesium By similarity.

Enzyme regulationi

Activated by calcium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi173 – 1731Manganese 1 By similarity
Metal bindingi175 – 1751Manganese 1 By similarity
Metal bindingi202 – 2021Manganese 1 By similarity
Metal bindingi202 – 2021Manganese 2 By similarity
Metal bindingi234 – 2341Manganese 2 By similarity
Active sitei235 – 2351Proton donor By similarity
Metal bindingi286 – 2861Manganese 2 By similarity
Metal bindingi393 – 3931Manganese 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi569 – 580121 Reviewed predictionAdd
BLAST
Calcium bindingi609 – 620122 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. manganese ion binding Source: InterPro
  4. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. detection of stimulus involved in sensory perception Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase with EF-hands 1 (EC:3.1.3.16)
Short name:
PPEF-1
Gene namesi
Name:Ppef1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1562772. Ppef1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Serine/threonine-protein phosphatase with EF-hands 1PRO_0000294517Add
BLAST

Proteomic databases

PaxDbiQ3SWT6.
PRIDEiQ3SWT6.

Expressioni

Gene expression databases

GenevestigatoriQ3SWT6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055729.

Structurei

3D structure databases

ProteinModelPortaliQ3SWT6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 4530IQAdd
BLAST
Domaini473 – 50836EF-hand 1Add
BLAST
Domaini556 – 59136EF-hand 2Add
BLAST
Domaini596 – 63136EF-hand 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 445324Catalytic By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the PPP phosphatase family.
Contains 3 EF-hand domains.
Contains 1 IQ domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000006820.
HOVERGENiHBG008238.
InParanoidiQ3SWT6.
KOiK13807.
PhylomeDBiQ3SWT6.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view]
PIRSFiPIRSF000912. PPEF. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00054. EFh. 2 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWT6-1 [UniParc]FASTAAdd to Basket

« Hide

MGCGSSSKKG KKSEKVVRAA LIIQNWYRRY RARLSARQHY ALAIFQSIEY    50
ADEQGQMQLS SFFSFMLENY TNTHKEDSAL VSRLFENTRL ESKDREEYVG 100
LIDVPDSYDG PRLQFPLTFT DINLLLQAFK QQQTLHAHYV LEVLFEARKI 150
LKQMPNFTRI QTFPAKEITI CGDLHGKLDD LMLIFYKNGL PSEKNPYVFN 200
GDFVDRGNNS MEILMILLVS FLVYPTDLHL NRGNHEDFMM NLRYGFTKEI 250
LQKYKLHGKK ILQVLEELYT WLPIGTIIDN EILVIHGGIS ESTDLNILQQ 300
LQRNKMKSVL MPPMSTNQEC NIKKNKAGPS EQSASEQLTK LEWEQIIDLL 350
WSDPRGKKGC YPNTSRGGGC YFGPDVTSKV LNKNQLKMVI RSHECKPDGY 400
EICHDGKVIT VFSASNYYEE GSNRGAYIRL SYGTSPQFFQ YQVTSTSCLN 450
PLYQRVNAME FSAFRILKER MIARKTDLIN AFELRDHSRT GKISLAQWAF 500
SMESILGLNL PWRSLSSHLV STDSSGSVDY MSSFDDIHIE KPMKDMKSDL 550
IETMYRYRSD LKIIFNIIDT DQSGLISMDE FRTMWKLFNA HYKVHIDDSQ 600
IDELASTMDS NKDGNIDFNE FLRAFYVVHK YETPESPLNK 640
Length:640
Mass (Da):73,966
Last modified:October 11, 2005 - v1
Checksum:iBC841AF1E11F031C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104696 mRNA. Translation: AAI04697.1.
RefSeqiNP_001030107.1. NM_001034935.1.
UniGeneiRn.103108.

Genome annotation databases

GeneIDi317498.
KEGGirno:317498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC104696 mRNA. Translation: AAI04697.1 .
RefSeqi NP_001030107.1. NM_001034935.1.
UniGenei Rn.103108.

3D structure databases

ProteinModelPortali Q3SWT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000055729.

Proteomic databases

PaxDbi Q3SWT6.
PRIDEi Q3SWT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 317498.
KEGGi rno:317498.

Organism-specific databases

CTDi 5475.
RGDi 1562772. Ppef1.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000006820.
HOVERGENi HBG008238.
InParanoidi Q3SWT6.
KOi K13807.
PhylomeDBi Q3SWT6.

Miscellaneous databases

NextBioi 671879.
PROi Q3SWT6.

Gene expression databases

Genevestigatori Q3SWT6.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
3.60.21.10. 2 hits.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR012008. Ser/Thr-Pase_EF-hand_contain.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
[Graphical view ]
PIRSFi PIRSF000912. PPEF. 1 hit.
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00054. EFh. 2 hits.
SM00015. IQ. 1 hit.
SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 2 hits.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPPE1_RAT
AccessioniPrimary (citable) accession number: Q3SWT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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