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Protein

Serine/threonine-protein phosphatase with EF-hands 1

Gene

Ppef1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in the recovery or adaptation response of photoreceptors. May have a role in development (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity
  • Mg2+By similarity

Enzyme regulationi

Activated by calcium.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi173Manganese 1By similarity1
Metal bindingi175Manganese 1By similarity1
Metal bindingi202Manganese 1By similarity1
Metal bindingi202Manganese 2By similarity1
Metal bindingi234Manganese 2By similarity1
Active sitei235Proton donorBy similarity1
Metal bindingi286Manganese 2By similarity1
Metal bindingi393Manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi569 – 5801PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi609 – 6202PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase with EF-hands 1 (EC:3.1.3.16)
Short name:
PPEF-1
Gene namesi
Name:Ppef1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562772 Ppef1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002945171 – 640Serine/threonine-protein phosphatase with EF-hands 1Add BLAST640

Proteomic databases

PRIDEiQ3SWT6

Structurei

3D structure databases

ProteinModelPortaliQ3SWT6
SMRiQ3SWT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 45IQAdd BLAST30
Domaini473 – 508EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini556 – 591EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini596 – 631EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 445CatalyticBy similarityAdd BLAST324

Sequence similaritiesi

Belongs to the PPP phosphatase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000006820
HOVERGENiHBG008238
InParanoidiQ3SWT6
KOiK13807
PhylomeDBiQ3SWT6

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013235 PPP_dom
IPR012008 Ser/Thr-Pase_EF-hand_contain
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00149 Metallophos, 1 hit
PF08321 PPP5, 1 hit
PIRSFiPIRSF000912 PPEF, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00156 PP2Ac, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SWT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGSSSKKG KKSEKVVRAA LIIQNWYRRY RARLSARQHY ALAIFQSIEY
60 70 80 90 100
ADEQGQMQLS SFFSFMLENY TNTHKEDSAL VSRLFENTRL ESKDREEYVG
110 120 130 140 150
LIDVPDSYDG PRLQFPLTFT DINLLLQAFK QQQTLHAHYV LEVLFEARKI
160 170 180 190 200
LKQMPNFTRI QTFPAKEITI CGDLHGKLDD LMLIFYKNGL PSEKNPYVFN
210 220 230 240 250
GDFVDRGNNS MEILMILLVS FLVYPTDLHL NRGNHEDFMM NLRYGFTKEI
260 270 280 290 300
LQKYKLHGKK ILQVLEELYT WLPIGTIIDN EILVIHGGIS ESTDLNILQQ
310 320 330 340 350
LQRNKMKSVL MPPMSTNQEC NIKKNKAGPS EQSASEQLTK LEWEQIIDLL
360 370 380 390 400
WSDPRGKKGC YPNTSRGGGC YFGPDVTSKV LNKNQLKMVI RSHECKPDGY
410 420 430 440 450
EICHDGKVIT VFSASNYYEE GSNRGAYIRL SYGTSPQFFQ YQVTSTSCLN
460 470 480 490 500
PLYQRVNAME FSAFRILKER MIARKTDLIN AFELRDHSRT GKISLAQWAF
510 520 530 540 550
SMESILGLNL PWRSLSSHLV STDSSGSVDY MSSFDDIHIE KPMKDMKSDL
560 570 580 590 600
IETMYRYRSD LKIIFNIIDT DQSGLISMDE FRTMWKLFNA HYKVHIDDSQ
610 620 630 640
IDELASTMDS NKDGNIDFNE FLRAFYVVHK YETPESPLNK
Length:640
Mass (Da):73,966
Last modified:October 11, 2005 - v1
Checksum:iBC841AF1E11F031C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104696 mRNA Translation: AAI04697.1
RefSeqiNP_001030107.1, NM_001034935.1
UniGeneiRn.103108

Genome annotation databases

GeneIDi317498
KEGGirno:317498

Similar proteinsi

Entry informationi

Entry nameiPPE1_RAT
AccessioniPrimary (citable) accession number: Q3SWT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health