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Protein

Janus kinase and microtubule-interacting protein 1

Gene

Jakmip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 1
Alternative name(s):
Multiple alpha helices and RNA-linker protein 1
Short name:
Marlin-1
Gene namesi
Name:Jakmip1
Synonyms:Marlin1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1562401 Jakmip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003230101 – 626Janus kinase and microtubule-interacting protein 1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei382PhosphoserineBy similarity1
Modified residuei470PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SWS9
PRIDEiQ3SWS9

PTM databases

iPTMnetiQ3SWS9
PhosphoSitePlusiQ3SWS9

Expressioni

Tissue specificityi

Specifically expressed in brain and testis by spermatogonia, spermatocytes, spermatozoa and Sertoli cells (at protein level).2 Publications

Gene expression databases

BgeeiENSRNOG00000004998
GenevisibleiQ3SWS9 RN

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with JAK1 and TYK2 (By similarity). Forms a complex with GABBR1 and KIF5B/kinesin-1.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006771

Structurei

3D structure databases

SMRiQ3SWS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 365Mediates association with microtubulesBy similarityAdd BLAST365
Regioni365 – 626Mediates interaction with TYK2 and GABBR1By similarityAdd BLAST262

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 255Sequence analysisAdd BLAST243
Coiled coili284 – 413Sequence analysisAdd BLAST130
Coiled coili490 – 604Sequence analysisAdd BLAST115

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6X Eukaryota
ENOG4110F4A LUCA
GeneTreeiENSGT00390000002812
HOGENOMiHOG000060161
HOVERGENiHBG054249
InParanoidiQ3SWS9
OMAiAYQSHQD
OrthoDBiEOG091G024X
PhylomeDBiQ3SWS9
TreeFamiTF331900

Family and domain databases

InterProiView protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C
PANTHERiPTHR18935 PTHR18935, 1 hit
PfamiView protein in Pfam
PF16034 JAKMIP_CC3, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SWS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKGRSKGE KPETETDSVQ MANEELRAKL TNIQIEFQQE KSKVGKLRER
60 70 80 90 100
LQEAKLEREQ EQRRHTAYIS ELKAKLHEEK TKELQALREA LIRQHEQEAA
110 120 130 140 150
RTAKIKEGEL QRLQATLNVL RDGAADKVKT ALLADAREEA RRTFDGERQR
160 170 180 190 200
LQQEILELKA ARKQAEEALS NCMQADKAKA ADLRAAYQAH QDEVHRIKRE
210 220 230 240 250
CERDIRRLMD EIKGKERVIL ALEKELGVQA GQTQRLLLQK EALDEQLVQV
260 270 280 290 300
KEAERHHSSP KRELPPGIGD MAELMGGQDQ HMDERDVRRF QLKIAELNSV
310 320 330 340 350
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLHSI
360 370 380 390 400
QRMEEKLKSL TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL
410 420 430 440 450
QVLEQQHVID DLSLERERLL RSKRHRGKSL KPPKKHVVET FFGFDEESVD
460 470 480 490 500
SETLSETSYN TDRTDRTPAT PEEDLDETTT REEADLRFCQ LTREYQALQR
510 520 530 540 550
AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE KLLVEKGQDA
560 570 580 590 600
AWVEEKQVLM RTNQDLLEKI YRLEMEENQL KSEMQDAKDQ NELLEFRVLE
610 620
LEVRDSICCK LSNGADILFE PKLKFV
Length:626
Mass (Da):73,107
Last modified:October 11, 2005 - v1
Checksum:i1EF2D3C42DFA552B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104677 mRNA Translation: AAI04678.1
BC104718 mRNA Translation: AAI04719.1
RefSeqiNP_001029066.1, NM_001033894.1
UniGeneiRn.18970

Genome annotation databases

EnsembliENSRNOT00000006771; ENSRNOP00000006771; ENSRNOG00000004998
GeneIDi305434
KEGGirno:305434

Similar proteinsi

Entry informationi

Entry nameiJKIP1_RAT
AccessioniPrimary (citable) accession number: Q3SWS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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