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Protein

Janus kinase and microtubule-interacting protein 1

Gene

Jakmip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 1
Alternative name(s):
Multiple alpha helices and RNA-linker protein 1
Short name:
Marlin-1
Gene namesi
Name:Jakmip1
Synonyms:Marlin1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1562401. Jakmip1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003230101 – 626Janus kinase and microtubule-interacting protein 1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei382PhosphoserineBy similarity1
Modified residuei470PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SWS9.
PRIDEiQ3SWS9.

PTM databases

iPTMnetiQ3SWS9.
PhosphoSitePlusiQ3SWS9.

Expressioni

Tissue specificityi

Specifically expressed in brain and testis by spermatogonia, spermatocytes, spermatozoa and Sertoli cells (at protein level).2 Publications

Gene expression databases

BgeeiENSRNOG00000004998.
GenevisibleiQ3SWS9. RN.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with JAK1 and TYK2 (By similarity). Forms a complex with GABBR1 and KIF5B/kinesin-1.By similarity2 Publications

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 365Mediates association with microtubulesBy similarityAdd BLAST365
Regioni365 – 626Mediates interaction with TYK2 and GABBR1By similarityAdd BLAST262

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 255Sequence analysisAdd BLAST243
Coiled coili284 – 413Sequence analysisAdd BLAST130
Coiled coili490 – 604Sequence analysisAdd BLAST115

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6X. Eukaryota.
ENOG4110F4A. LUCA.
GeneTreeiENSGT00390000002812.
HOGENOMiHOG000060161.
HOVERGENiHBG054249.
InParanoidiQ3SWS9.
OMAiMVELMGV.
OrthoDBiEOG091G024X.
PhylomeDBiQ3SWS9.
TreeFamiTF331900.

Family and domain databases

InterProiIPR031994. JAKMIP_C.
[Graphical view]
PfamiPF16034. JAKMIP_CC3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKGRSKGE KPETETDSVQ MANEELRAKL TNIQIEFQQE KSKVGKLRER
60 70 80 90 100
LQEAKLEREQ EQRRHTAYIS ELKAKLHEEK TKELQALREA LIRQHEQEAA
110 120 130 140 150
RTAKIKEGEL QRLQATLNVL RDGAADKVKT ALLADAREEA RRTFDGERQR
160 170 180 190 200
LQQEILELKA ARKQAEEALS NCMQADKAKA ADLRAAYQAH QDEVHRIKRE
210 220 230 240 250
CERDIRRLMD EIKGKERVIL ALEKELGVQA GQTQRLLLQK EALDEQLVQV
260 270 280 290 300
KEAERHHSSP KRELPPGIGD MAELMGGQDQ HMDERDVRRF QLKIAELNSV
310 320 330 340 350
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLHSI
360 370 380 390 400
QRMEEKLKSL TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL
410 420 430 440 450
QVLEQQHVID DLSLERERLL RSKRHRGKSL KPPKKHVVET FFGFDEESVD
460 470 480 490 500
SETLSETSYN TDRTDRTPAT PEEDLDETTT REEADLRFCQ LTREYQALQR
510 520 530 540 550
AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE KLLVEKGQDA
560 570 580 590 600
AWVEEKQVLM RTNQDLLEKI YRLEMEENQL KSEMQDAKDQ NELLEFRVLE
610 620
LEVRDSICCK LSNGADILFE PKLKFV
Length:626
Mass (Da):73,107
Last modified:October 11, 2005 - v1
Checksum:i1EF2D3C42DFA552B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104677 mRNA. Translation: AAI04678.1.
BC104718 mRNA. Translation: AAI04719.1.
RefSeqiNP_001029066.1. NM_001033894.1.
UniGeneiRn.18970.

Genome annotation databases

EnsembliENSRNOT00000006771; ENSRNOP00000006771; ENSRNOG00000004998.
GeneIDi305434.
KEGGirno:305434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104677 mRNA. Translation: AAI04678.1.
BC104718 mRNA. Translation: AAI04719.1.
RefSeqiNP_001029066.1. NM_001033894.1.
UniGeneiRn.18970.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3SWS9.
PhosphoSitePlusiQ3SWS9.

Proteomic databases

PaxDbiQ3SWS9.
PRIDEiQ3SWS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006771; ENSRNOP00000006771; ENSRNOG00000004998.
GeneIDi305434.
KEGGirno:305434.

Organism-specific databases

CTDi152789.
RGDi1562401. Jakmip1.

Phylogenomic databases

eggNOGiENOG410II6X. Eukaryota.
ENOG4110F4A. LUCA.
GeneTreeiENSGT00390000002812.
HOGENOMiHOG000060161.
HOVERGENiHBG054249.
InParanoidiQ3SWS9.
OMAiMVELMGV.
OrthoDBiEOG091G024X.
PhylomeDBiQ3SWS9.
TreeFamiTF331900.

Miscellaneous databases

PROiQ3SWS9.

Gene expression databases

BgeeiENSRNOG00000004998.
GenevisibleiQ3SWS9. RN.

Family and domain databases

InterProiIPR031994. JAKMIP_C.
[Graphical view]
PfamiPF16034. JAKMIP_CC3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJKIP1_RAT
AccessioniPrimary (citable) accession number: Q3SWS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.