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Protein

mRNA export factor

Gene

Rae1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:Rae1
Synonyms:Mrnp41
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1311540. Rae1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear envelope Source: GO_Central
  • nuclear pore Source: GO_Central
  • nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368mRNA export factorPRO_0000237587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SWS8.
PRIDEiQ3SWS8.

Expressioni

Gene expression databases

GenevisibleiQ3SWS8. RN.

Interactioni

Subunit structurei

Interacts with NUP98 (By similarity). Interacts with MYCBP2 (PubMed:22357847).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCBP2O755922EBI-6920222,EBI-1043774From a different organism.
rpm-1Q175512EBI-6920222,EBI-6920110From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi263329. 1 interaction.
IntActiQ3SWS8. 2 interactions.
STRINGi10116.ENSRNOP00000029085.

Structurei

3D structure databases

ProteinModelPortaliQ3SWS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 7943WD 1Add
BLAST
Repeati84 – 11431WD 2Add
BLAST
Repeati125 – 15733WD 3Add
BLAST
Repeati168 – 20639WD 4Add
BLAST
Repeati215 – 25541WD 5Add
BLAST
Repeati271 – 30131WD 6Add
BLAST
Repeati310 – 34637WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOGENOMiHOG000208823.
HOVERGENiHBG002942.
InParanoidiQ3SWS8.
KOiK14298.
OMAiKGHEYYN.
OrthoDBiEOG7H792F.
PhylomeDBiQ3SWS8.
TreeFamiTF105481.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFGTTSGF GTGGTSMFGS TTTDNHNPMK DIEVTSSPDD SIGCLSFSPP
60 70 80 90 100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLNSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD
160 170 180 190 200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPVAA CGFNHNGNIF AYASSYDWSK GHEFYNPQKK
360
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):40,919
Last modified:October 11, 2005 - v1
Checksum:i90EE24DCE33D7648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104721 mRNA. Translation: AAI04722.1.
BC105758 mRNA. Translation: AAI05759.1.
RefSeqiNP_001028880.1. NM_001033708.1.
XP_008760741.1. XM_008762519.1.
UniGeneiRn.14600.

Genome annotation databases

EnsembliENSRNOT00000038182; ENSRNOP00000029085; ENSRNOG00000021295.
GeneIDi362281.
KEGGirno:362281.
UCSCiRGD:1311540. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104721 mRNA. Translation: AAI04722.1.
BC105758 mRNA. Translation: AAI05759.1.
RefSeqiNP_001028880.1. NM_001033708.1.
XP_008760741.1. XM_008762519.1.
UniGeneiRn.14600.

3D structure databases

ProteinModelPortaliQ3SWS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263329. 1 interaction.
IntActiQ3SWS8. 2 interactions.
STRINGi10116.ENSRNOP00000029085.

Proteomic databases

PaxDbiQ3SWS8.
PRIDEiQ3SWS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038182; ENSRNOP00000029085; ENSRNOG00000021295.
GeneIDi362281.
KEGGirno:362281.
UCSCiRGD:1311540. rat.

Organism-specific databases

CTDi8480.
RGDi1311540. Rae1.

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOGENOMiHOG000208823.
HOVERGENiHBG002942.
InParanoidiQ3SWS8.
KOiK14298.
OMAiKGHEYYN.
OrthoDBiEOG7H792F.
PhylomeDBiQ3SWS8.
TreeFamiTF105481.

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiQ3SWS8.

Gene expression databases

GenevisibleiQ3SWS8. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate and Thymus.
  2. "RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans."
    Grill B., Chen L., Tulgren E.D., Baker S.T., Bienvenut W., Anderson M., Quadroni M., Jin Y., Garner C.C.
    J. Neurosci. 32:2628-2636(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYCBP2.

Entry informationi

Entry nameiRAE1L_RAT
AccessioniPrimary (citable) accession number: Q3SWS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.