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Q3SWI2

- SYL_NITWN

UniProt

Q3SWI2 - SYL_NITWN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei633 – 6331ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNWIN323098:GJEG-92-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Nwi_0091
    OrganismiNitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
    Taxonomic identifieri323098 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000002531: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 883883Leucine--tRNA ligasePRO_1000009383Add
    BLAST

    Proteomic databases

    PRIDEiQ3SWI2.

    Interactioni

    Protein-protein interaction databases

    STRINGi323098.Nwi_0091.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SWI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi630 – 6345"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3SWI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSERYNARD AEPRWQAEWD RQAIFATKND DPREKYYVLE MFPYPSGRIH    50
    IGHVRNYTLG DVIARYMRAR GYNVLHPMGW DAFGLPAENA AIERKIAPKA 100
    WTYDNIKAMK KQLRSIGLSL DWSREIATCD PAYYKHQQKM FLDFLRAGLA 150
    EREKRKINWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITKFS 200
    QELLDALGTL DRWPDKVRLM QRNWIGRSEG LLIRFALDAT TTPNNESELK 250
    IFTTRPDTLF GARFMAIAPD HPLAQAAAKD NPALAGFIAE CKQRGTAQAE 300
    IDTAEKMGFD TGIRAIHPFD AAWALPVYVA NFILMEYGTG AIFGCPAHDQ 350
    RDLDFVNKYG LGNTPVVCPE GQDPASFVIT DTAYDGDGRM INSRFLDGMS 400
    ADAAKEEVAK RLEGETRGNE PVAERKVNFR LRDWGISRQR YWGCPIPVIH 450
    CPNCDVVPVP EKDLPVTLPE DVTFDRPGNA LDHHPTWKHV DCPKCGGKAT 500
    RETDTMDTFV DSSWYFARFT DPWNDSAPTT REVADRMLPV DQYIGGVEHA 550
    ILHLLYSRFF TRAMKATGHL GMDEPFKGMF TQGMVVHETY RKPDGGWASP 600
    EEVRIEVDGN NRRATLITTG EPVEIGAVEK MSKSKRNTVD PDDIIGSYGA 650
    DTARWFMLSD SPPDRDVIWS EEGVQGAARF MQRLWRLVNE AADAGKAAPQ 700
    DRPATFGSDA LTLRKAAHGA LDRVSTGIER LHFNVCLANI REFANELADA 750
    LARSRSNKSA PARDLAPDLS WSLREAAIIL VQIFSPMMPH LAEECWQRAL 800
    GQTGLVSQAR WPQIEPDLLI EDSITLPVQV NGKKRGEVTV ASDAGNPEIE 850
    AAVLALDAVK QALGGKQARK IIIVPRRIVS VVG 883
    Length:883
    Mass (Da):98,985
    Last modified:October 11, 2005 - v1
    Checksum:i61369988A74A46CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000115 Genomic DNA. Translation: ABA03359.1.
    RefSeqiYP_316711.1. NC_007406.1.

    Genome annotation databases

    EnsemblBacteriaiABA03359; ABA03359; Nwi_0091.
    GeneIDi3675056.
    KEGGinwi:Nwi_0091.
    PATRICi22696497. VBINitWin102302_0104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000115 Genomic DNA. Translation: ABA03359.1 .
    RefSeqi YP_316711.1. NC_007406.1.

    3D structure databases

    ProteinModelPortali Q3SWI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323098.Nwi_0091.

    Proteomic databases

    PRIDEi Q3SWI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA03359 ; ABA03359 ; Nwi_0091 .
    GeneIDi 3675056.
    KEGGi nwi:Nwi_0091.
    PATRICi 22696497. VBINitWin102302_0104.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci NWIN323098:GJEG-92-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
      Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
      Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nb-255 / ATCC 25391.

    Entry informationi

    Entry nameiSYL_NITWN
    AccessioniPrimary (citable) accession number: Q3SWI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3