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Q3SWI2

- SYL_NITWN

UniProt

Q3SWI2 - SYL_NITWN

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Protein

Leucine--tRNA ligase

Gene
leuS, Nwi_0091
Organism
Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNWIN323098:GJEG-92-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Nwi_0091
OrganismiNitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Taxonomic identifieri323098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000002531: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 883883Leucine--tRNA ligaseUniRule annotationPRO_1000009383Add
BLAST

Proteomic databases

PRIDEiQ3SWI2.

Interactioni

Protein-protein interaction databases

STRINGi323098.Nwi_0091.

Structurei

3D structure databases

ProteinModelPortaliQ3SWI2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotationAdd
BLAST
Motifi630 – 6345"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SWI2-1 [UniParc]FASTAAdd to Basket

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MTSERYNARD AEPRWQAEWD RQAIFATKND DPREKYYVLE MFPYPSGRIH    50
IGHVRNYTLG DVIARYMRAR GYNVLHPMGW DAFGLPAENA AIERKIAPKA 100
WTYDNIKAMK KQLRSIGLSL DWSREIATCD PAYYKHQQKM FLDFLRAGLA 150
EREKRKINWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITKFS 200
QELLDALGTL DRWPDKVRLM QRNWIGRSEG LLIRFALDAT TTPNNESELK 250
IFTTRPDTLF GARFMAIAPD HPLAQAAAKD NPALAGFIAE CKQRGTAQAE 300
IDTAEKMGFD TGIRAIHPFD AAWALPVYVA NFILMEYGTG AIFGCPAHDQ 350
RDLDFVNKYG LGNTPVVCPE GQDPASFVIT DTAYDGDGRM INSRFLDGMS 400
ADAAKEEVAK RLEGETRGNE PVAERKVNFR LRDWGISRQR YWGCPIPVIH 450
CPNCDVVPVP EKDLPVTLPE DVTFDRPGNA LDHHPTWKHV DCPKCGGKAT 500
RETDTMDTFV DSSWYFARFT DPWNDSAPTT REVADRMLPV DQYIGGVEHA 550
ILHLLYSRFF TRAMKATGHL GMDEPFKGMF TQGMVVHETY RKPDGGWASP 600
EEVRIEVDGN NRRATLITTG EPVEIGAVEK MSKSKRNTVD PDDIIGSYGA 650
DTARWFMLSD SPPDRDVIWS EEGVQGAARF MQRLWRLVNE AADAGKAAPQ 700
DRPATFGSDA LTLRKAAHGA LDRVSTGIER LHFNVCLANI REFANELADA 750
LARSRSNKSA PARDLAPDLS WSLREAAIIL VQIFSPMMPH LAEECWQRAL 800
GQTGLVSQAR WPQIEPDLLI EDSITLPVQV NGKKRGEVTV ASDAGNPEIE 850
AAVLALDAVK QALGGKQARK IIIVPRRIVS VVG 883
Length:883
Mass (Da):98,985
Last modified:October 11, 2005 - v1
Checksum:i61369988A74A46CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000115 Genomic DNA. Translation: ABA03359.1.
RefSeqiYP_316711.1. NC_007406.1.

Genome annotation databases

EnsemblBacteriaiABA03359; ABA03359; Nwi_0091.
GeneIDi3675056.
KEGGinwi:Nwi_0091.
PATRICi22696497. VBINitWin102302_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000115 Genomic DNA. Translation: ABA03359.1 .
RefSeqi YP_316711.1. NC_007406.1.

3D structure databases

ProteinModelPortali Q3SWI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323098.Nwi_0091.

Proteomic databases

PRIDEi Q3SWI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA03359 ; ABA03359 ; Nwi_0091 .
GeneIDi 3675056.
KEGGi nwi:Nwi_0091.
PATRICi 22696497. VBINitWin102302_0104.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NWIN323098:GJEG-92-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
    Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
    Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nb-255 / ATCC 25391.

Entry informationi

Entry nameiSYL_NITWN
AccessioniPrimary (citable) accession number: Q3SWI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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