ID   COAA_NITWN              Reviewed;         318 AA.
AC   Q3SWF3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Pantothenate kinase;
DE            EC=2.7.1.33;
DE   AltName: Full=Pantothenic acid kinase;
GN   Name=coaA; OrderedLocusNames=Nwi_0120;
OS   Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16517654; DOI=10.1128/AEM.72.3.2050-2063.2006;
RA   Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L.,
RA   Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J.,
RA   Arp D.J., Hickey W.J.;
RT   "Genome sequence of the chemolithoautotrophic nitrite-oxidizing
RT   bacterium Nitrobacter winogradskyi Nb-255.";
RL   Appl. Environ. Microbiol. 72:2050-2063(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
CC       phosphopantothenate.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme
CC       A from pantothenate: step 1/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the prokaryotic pantothenate kinase family.
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DR   EMBL; CP000115; ABA03388.1; -; Genomic_DNA.
DR   RefSeq; YP_316740.1; -.
DR   GeneID; 3676189; -.
DR   GenomeReviews; CP000115_GR; Nwi_0120.
DR   KEGG; nwi:Nwi_0120; -.
DR   NMPDR; fig|323098.3.peg.509; -.
DR   HOGENOM; Q3SWF3; -.
DR   OMA; Q3SWF3; PKVDLIT.
DR   BioCyc; NWIN323098:NWI_0120-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004594; F:pantothenate kinase activity; IEA:HAMAP.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00215; -; 1.
DR   InterPro; IPR004566; PanK_bact.
DR   PANTHER; PTHR10285:SF7; PanK_bact; 1.
DR   PIRSF; PIRSF000545; Pantothenate_kin; 1.
DR   TIGRFAMs; TIGR00554; panK_bact; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    318       Pantothenate kinase.
FT                                /FTId=PRO_1000043236.
FT   NP_BIND      96    103       ATP (Potential).
SQ   SEQUENCE   318 AA;  36222 MW;  BE6FAC8572E05F26 CRC64;
     MDSRADQQQY NPYRVFPRAE WAKLRHDMPM TLAANEIAAL RSMHDRLDLV EVEEIYLPLS
     RLLSIYVAAM QRLFVAQRQF LGIHDRKVPY IIGVAGSVAV GKSTTARVLQ ALLARWSPRP
     KVELVTTDGF LLPNAVLERR GLMQKKGFPE SYDLPMLLSF LSDIKAGRAP VRAPVYSHLT
     YDIVPDSWIE VSHPDILIVE GVNVLQTGPL PRDGRAIPVV SDFFDFSVYL DAEEPVLRDW
     YVTRFLALRD SAFQDPRSYF NRYALLSDDE AIATAIAIWE RTNRANLEDN ILPTRPRANL
     ILKKGADHVV ERVALRRL
//