Q3SWF3 (COAA_NITWN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	Nwi_0120

Organism

Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391) [Complete proteome] [HAMAP]

Taxonomic identifier

323098 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Pantothenate kinase HAMAP MF_00215		PRO_1000043236
Regions
	Nucleotide binding	96 – 103	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3SWF3 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: BE6FAC8572E05F26	FASTA	318	36,222
	10 20 30 40 50 60 MDSRADQQQY NPYRVFPRAE WAKLRHDMPM TLAANEIAAL RSMHDRLDLV EVEEIYLPLS 70 80 90 100 110 120 RLLSIYVAAM QRLFVAQRQF LGIHDRKVPY IIGVAGSVAV GKSTTARVLQ ALLARWSPRP 130 140 150 160 170 180 KVELVTTDGF LLPNAVLERR GLMQKKGFPE SYDLPMLLSF LSDIKAGRAP VRAPVYSHLT 190 200 210 220 230 240 YDIVPDSWIE VSHPDILIVE GVNVLQTGPL PRDGRAIPVV SDFFDFSVYL DAEEPVLRDW 250 260 270 280 290 300 YVTRFLALRD SAFQDPRSYF NRYALLSDDE AIATAIAIWE RTNRANLEDN ILPTRPRANL 310 ILKKGADHVV ERVALRRL

References

[1]

"Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255." Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J. Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed: 16517654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nb-255 / ATCC 25391.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000115 Genomic DNA. Translation: ABA03388.1.
RefSeq	YP_316740.1. NC_007406.1.
3D structure databases
ProteinModelPortal	Q3SWF3.
SMR	Q3SWF3. Positions 7-317.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SWF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3676189.
GenomeReviews	Gene locus Nwi_0120 in contig CP000115_GR.
KEGG	nwi:Nwi_0120.
NMPDR	fig|323098.3.peg.509.
PATRIC	22696557. VBINitWin102302_0134.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q3SWF3.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	NWIN323098:NWI_0120-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_NITWN

Accession

Primary (citable) accession number: Q3SWF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 11, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program