Q3SVF7 (Q3SVF7_NITWN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	Nwi_0467

Organism

Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391) [Complete proteome] [HAMAP] EMBL ABA03734.1

Taxonomic identifier

323098 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length	652 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ABA03734.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	515	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	607	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q3SVF7 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: A553C7FEA227DE5F	FASTA	652	72,404
	10 20 30 40 50 60 MSDKIYDVSA DWARRAWVDD AKYREMYARS IKDPNGFWSE AAQRLDWITP FTKVENTSFE 70 80 90 100 110 120 LGKVSIKWFE DGVLNAAYNC IDRHLEKRGD QTAIIWEGDD PSQSRHITYR ELHDEVCKMA 130 140 150 160 170 180 NILRLRNVKK GDRVTIYLPM IPEAAYAILA CARIGAIHSV VFGGFSPDSI AGRLRDCKSR 190 200 210 220 230 240 VIITSDEGLR GGRTIAMKAN VDAAIEKVNG EVDWVIVVKR TGGNIDMNPT RDVWYHEAAA 250 260 270 280 290 300 VVESECPCEP MNAEDPLFIL YTSGSTGQPK GVLHTTAGYL VFVAMTHQYV FDYHDGDIYW 310 320 330 340 350 360 CTADVGWVTG HSYILYGPLA NGATTMMFEG VPNYPDTSRF WNVIDKHKVN IFYTAPTAIR 370 380 390 400 410 420 ALMQAGDEPV KKTSRASLRL LGSVGEPINP EAWEWYHRVV GDGRCPVVDT WWQTETGGIM 430 440 450 460 470 480 ISALPGAIAQ KPGSATKPFF GIAPEIVDAD GNILEGECSG NLCIARSWPA QVRTVYGDHA 490 500 510 520 530 540 RFEQTYFSSY KGRYFSGDGC RRDADGYYWI TGRVDDVINV SGHRMGTAEV ESSLVAHESV 550 560 570 580 590 600 SEAAVVGYPH NIKGQGIYAY VTLMKGVEPS ESLRKELVAW VRKDIGPIAS PDLIQFAPGL 610 620 630 640 650 PKTRSGKIMR RILRKIAEDE PSSLGDTTTL ADPAVVDDLV RNRQNRKDGA VA

References

[1]

"Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255." Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J. Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed: 16517654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000115 Genomic DNA. Translation: ABA03734.1.
RefSeq	YP_317086.1. NC_007406.1.
3D structure databases
ProteinModelPortal	Q3SVF7.
SMR	Q3SVF7. Positions 8-644.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SVF7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3674868.
GenomeReviews	Gene locus Nwi_0467 in contig CP000115_GR.
KEGG	nwi:Nwi_0467.
NMPDR	fig|323098.3.peg.158.
PATRIC	22697334. VBINitWin102302_0515.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	WNCIERN.
PhylomeDB	Q3SVF7.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	NWIN323098:NWI_0467-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q3SVF7_NITWN

Accession

Primary (citable) accession number: Q3SVF7

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)