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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Nwi_1048
OrganismiNitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Taxonomic identifieri323098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
Proteomesi
  • UP000002531 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalUniRule annotationAdd BLAST21
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Transmembranei102 – 122HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 160HelicalUniRule annotationAdd BLAST19
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei207 – 227HelicalUniRule annotationAdd BLAST21
Transmembranei244 – 264HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21
Transmembranei296 – 316HelicalUniRule annotationAdd BLAST21
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002354591 – 368Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi323098.Nwi_1048.

Structurei

3D structure databases

SMRiQ3STT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3STT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYWLIDLSN TVPGLGIFKP LLNVFRYITF RTGGAVVTGA LFVFLFGPWI
60 70 80 90 100
IDNLRLRQGK GQPIRADGPQ SHLVSKKGTP TMGGLMILSG LVVSTVLWAN
110 120 130 140 150
PLNPYVWIVL AVTLGFGLIG FYDDYLKVTK QTHAGFSGRT RLLLELLIAL
160 170 180 190 200
AACYALTRLG REPFSTALVI PFFKDVALDL GWFFLGFGAF IIVGAGNAVN
210 220 230 240 250
LTDGLDGLAI VPVMIAAASF AMIAYLAGNA VFADYLQINY IAGAGELAVL
260 270 280 290 300
CGAVLGAGLG FLWFNAPPAS IFMGDTGSLA LGGMLGSIAV AVKHEIVLAV
310 320 330 340 350
IGGLFVLEAV SVIVQVASFK LTGKRIFKMA PIHHHFEQLG WTEPQIVIRF
360
WIISVMLALA GLSTLKLR
Length:368
Mass (Da):39,451
Last modified:October 11, 2005 - v1
Checksum:i7731CCF73312F0DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000115 Genomic DNA. Translation: ABA04310.1.
RefSeqiWP_011314344.1. NC_007406.1.

Genome annotation databases

EnsemblBacteriaiABA04310; ABA04310; Nwi_1048.
KEGGinwi:Nwi_1048.

Similar proteinsi

Entry informationi

Entry nameiMRAY_NITWN
AccessioniPrimary (citable) accession number: Q3STT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2005
Last modified: June 7, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families