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Q3ST46

- GCSP_NITWN

UniProt

Q3ST46 - GCSP_NITWN

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Nwi_1284
Organism
Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNWIN323098:GJEG-1307-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Nwi_1284
OrganismiNitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Taxonomic identifieri323098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000002531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei699 – 6991N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi323098.Nwi_1284.

Structurei

3D structure databases

ProteinModelPortaliQ3ST46.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ST46-1 [UniParc]FASTAAdd to Basket

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MIAREEPATT FARRHIGPSS RDIAAMLETV GAKSLEALMN EALPPSIRQK    50
TPLDLGEGFS ETEVLTHMQA LAAQNQPLTS LIGQGYSGTI LPAVIQRNIL 100
ENPAWYTAYT PYQPEISQGR LEALFNFQTM ICDLTGLDVA NASLLDEATA 150
AAEAMALAER ASSVKTKAFF VDHEVHPQTL AVLRTRAEPL GWTLVTGDPL 200
HDLDKADVFG AVLQYPGTSG VVRDLRPAIA AIKAKGGLAV VAADLLALTL 250
LTSPGVLGAD IAIGSAQRFG VPMGYGGPHA AYMAVCNALK RLLPGRLVGL 300
SVDSRGTPAY RLALQTREQH IRREKATSNI CTAQVLLAVI SSMYAVYHGP 350
EGLAQIARTV HRHTATLAAG LTRLGFAPLN STAFDTLTVN AGERQSEIVK 400
RASSQGINLR INADGTLGIA LDELTIEETV EALWRAFGAT WSYADVEAHA 450
PDLLPADLKR KTAYLTHPVF HEHRSETELL RYMRKLSDRD LALDRAMIPL 500
GSCTMKLNAT TEMIPLTWAA FANLHPFAPP EQAEGYFTLF ENFEEWLLDI 550
TGYDAISLQP NSGAQGEYAG LLAIRGYHAA RGESHRTVCL IPSSAHGTNP 600
ASANMAGMDV VVVACDARGD VDVDDLRTKS TQHADRLAAI MITYPSTHGV 650
FEERIREICD IVHGHGGQVY LDGANMNAQV GLSRPGDYGA DVSHLNLHKT 700
FCIPHGGGGP GMGPIGVKAH LAPFLPGHPA IDDATPSAVG PVSAAPFGSA 750
SILTISYIYI LMMGSEGLKR ATEVAILNAN YIAQRLDPHF PVLYRNVKGR 800
VAHECIIDPR ALKAKTGVTV DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT 850
ESESKAELDR FCDAMIAIRQ EIAEIEAGRW KVEASPLRHA PHTAHDIADD 900
AWSRPYSRAQ GCFPSGSSRS DKYWCPVGRV DNAYGDRNLV CSCPPVEDYA 950
QAAE 954
Length:954
Mass (Da):102,794
Last modified:October 11, 2005 - v1
Checksum:i24D9EE73A28C9B9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000115 Genomic DNA. Translation: ABA04545.1.
RefSeqiWP_011314571.1. NC_007406.1.
YP_317897.1. NC_007406.1.

Genome annotation databases

EnsemblBacteriaiABA04545; ABA04545; Nwi_1284.
GeneIDi3675080.
KEGGinwi:Nwi_1284.
PATRICi22699210. VBINitWin102302_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000115 Genomic DNA. Translation: ABA04545.1 .
RefSeqi WP_011314571.1. NC_007406.1.
YP_317897.1. NC_007406.1.

3D structure databases

ProteinModelPortali Q3ST46.
ModBasei Search...

Protein-protein interaction databases

STRINGi 323098.Nwi_1284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA04545 ; ABA04545 ; Nwi_1284 .
GeneIDi 3675080.
KEGGi nwi:Nwi_1284.
PATRICi 22699210. VBINitWin102302_1439.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NWIN323098:GJEG-1307-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
    Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
    Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nb-255 / ATCC 25391.

Entry informationi

Entry nameiGCSP_NITWN
AccessioniPrimary (citable) accession number: Q3ST46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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