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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciNWIN323098:G1G55-1311-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Nwi_1284
OrganismiNitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Taxonomic identifieri323098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002271091 – 954Glycine dehydrogenase (decarboxylating)Add BLAST954

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei699N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ3ST46

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi323098.Nwi_1284

Structurei

3D structure databases

ProteinModelPortaliQ3ST46
SMRiQ3ST46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ST46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAREEPATT FARRHIGPSS RDIAAMLETV GAKSLEALMN EALPPSIRQK
60 70 80 90 100
TPLDLGEGFS ETEVLTHMQA LAAQNQPLTS LIGQGYSGTI LPAVIQRNIL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALFNFQTM ICDLTGLDVA NASLLDEATA
160 170 180 190 200
AAEAMALAER ASSVKTKAFF VDHEVHPQTL AVLRTRAEPL GWTLVTGDPL
210 220 230 240 250
HDLDKADVFG AVLQYPGTSG VVRDLRPAIA AIKAKGGLAV VAADLLALTL
260 270 280 290 300
LTSPGVLGAD IAIGSAQRFG VPMGYGGPHA AYMAVCNALK RLLPGRLVGL
310 320 330 340 350
SVDSRGTPAY RLALQTREQH IRREKATSNI CTAQVLLAVI SSMYAVYHGP
360 370 380 390 400
EGLAQIARTV HRHTATLAAG LTRLGFAPLN STAFDTLTVN AGERQSEIVK
410 420 430 440 450
RASSQGINLR INADGTLGIA LDELTIEETV EALWRAFGAT WSYADVEAHA
460 470 480 490 500
PDLLPADLKR KTAYLTHPVF HEHRSETELL RYMRKLSDRD LALDRAMIPL
510 520 530 540 550
GSCTMKLNAT TEMIPLTWAA FANLHPFAPP EQAEGYFTLF ENFEEWLLDI
560 570 580 590 600
TGYDAISLQP NSGAQGEYAG LLAIRGYHAA RGESHRTVCL IPSSAHGTNP
610 620 630 640 650
ASANMAGMDV VVVACDARGD VDVDDLRTKS TQHADRLAAI MITYPSTHGV
660 670 680 690 700
FEERIREICD IVHGHGGQVY LDGANMNAQV GLSRPGDYGA DVSHLNLHKT
710 720 730 740 750
FCIPHGGGGP GMGPIGVKAH LAPFLPGHPA IDDATPSAVG PVSAAPFGSA
760 770 780 790 800
SILTISYIYI LMMGSEGLKR ATEVAILNAN YIAQRLDPHF PVLYRNVKGR
810 820 830 840 850
VAHECIIDPR ALKAKTGVTV DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT
860 870 880 890 900
ESESKAELDR FCDAMIAIRQ EIAEIEAGRW KVEASPLRHA PHTAHDIADD
910 920 930 940 950
AWSRPYSRAQ GCFPSGSSRS DKYWCPVGRV DNAYGDRNLV CSCPPVEDYA

QAAE
Length:954
Mass (Da):102,794
Last modified:October 11, 2005 - v1
Checksum:i24D9EE73A28C9B9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000115 Genomic DNA Translation: ABA04545.1
RefSeqiWP_011314571.1, NC_007406.1

Genome annotation databases

EnsemblBacteriaiABA04545; ABA04545; Nwi_1284
KEGGinwi:Nwi_1284

Similar proteinsi

Entry informationi

Entry nameiGCSP_NITWN
AccessioniPrimary (citable) accession number: Q3ST46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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