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Q3ST46 (GCSP_NITWN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Nwi_1284
OrganismNitrobacter winogradskyi (strain Nb-255 / ATCC 25391) [Complete proteome] [HAMAP]
Taxonomic identifier323098 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227109

Amino acid modifications

Modified residue6991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ST46 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 24D9EE73A28C9B9A

FASTA954102,794
        10         20         30         40         50         60 
MIAREEPATT FARRHIGPSS RDIAAMLETV GAKSLEALMN EALPPSIRQK TPLDLGEGFS 

        70         80         90        100        110        120 
ETEVLTHMQA LAAQNQPLTS LIGQGYSGTI LPAVIQRNIL ENPAWYTAYT PYQPEISQGR 

       130        140        150        160        170        180 
LEALFNFQTM ICDLTGLDVA NASLLDEATA AAEAMALAER ASSVKTKAFF VDHEVHPQTL 

       190        200        210        220        230        240 
AVLRTRAEPL GWTLVTGDPL HDLDKADVFG AVLQYPGTSG VVRDLRPAIA AIKAKGGLAV 

       250        260        270        280        290        300 
VAADLLALTL LTSPGVLGAD IAIGSAQRFG VPMGYGGPHA AYMAVCNALK RLLPGRLVGL 

       310        320        330        340        350        360 
SVDSRGTPAY RLALQTREQH IRREKATSNI CTAQVLLAVI SSMYAVYHGP EGLAQIARTV 

       370        380        390        400        410        420 
HRHTATLAAG LTRLGFAPLN STAFDTLTVN AGERQSEIVK RASSQGINLR INADGTLGIA 

       430        440        450        460        470        480 
LDELTIEETV EALWRAFGAT WSYADVEAHA PDLLPADLKR KTAYLTHPVF HEHRSETELL 

       490        500        510        520        530        540 
RYMRKLSDRD LALDRAMIPL GSCTMKLNAT TEMIPLTWAA FANLHPFAPP EQAEGYFTLF 

       550        560        570        580        590        600 
ENFEEWLLDI TGYDAISLQP NSGAQGEYAG LLAIRGYHAA RGESHRTVCL IPSSAHGTNP 

       610        620        630        640        650        660 
ASANMAGMDV VVVACDARGD VDVDDLRTKS TQHADRLAAI MITYPSTHGV FEERIREICD 

       670        680        690        700        710        720 
IVHGHGGQVY LDGANMNAQV GLSRPGDYGA DVSHLNLHKT FCIPHGGGGP GMGPIGVKAH 

       730        740        750        760        770        780 
LAPFLPGHPA IDDATPSAVG PVSAAPFGSA SILTISYIYI LMMGSEGLKR ATEVAILNAN 

       790        800        810        820        830        840 
YIAQRLDPHF PVLYRNVKGR VAHECIIDPR ALKAKTGVTV DDIAKRLIDY GFHAPTMSFP 

       850        860        870        880        890        900 
VPGTLMIEPT ESESKAELDR FCDAMIAIRQ EIAEIEAGRW KVEASPLRHA PHTAHDIADD 

       910        920        930        940        950 
AWSRPYSRAQ GCFPSGSSRS DKYWCPVGRV DNAYGDRNLV CSCPPVEDYA QAAE 

« Hide

References

[1]"Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nb-255 / ATCC 25391.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000115 Genomic DNA. Translation: ABA04545.1.
RefSeqYP_317897.1. NC_007406.1.

3D structure databases

ProteinModelPortalQ3ST46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING323098.Nwi_1284.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA04545; ABA04545; Nwi_1284.
GeneID3675080.
KEGGnwi:Nwi_1284.
PATRIC22699210. VBINitWin102302_1439.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycNWIN323098:GJEG-1307-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_NITWN
AccessionPrimary (citable) accession number: Q3ST46
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families