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Q3ST46

- GCSP_NITWN

UniProt

Q3ST46 - GCSP_NITWN

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciNWIN323098:GJEG-1307-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Nwi_1284
    OrganismiNitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
    Taxonomic identifieri323098 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000002531: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000227109Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei699 – 6991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi323098.Nwi_1284.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ST46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3ST46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIAREEPATT FARRHIGPSS RDIAAMLETV GAKSLEALMN EALPPSIRQK    50
    TPLDLGEGFS ETEVLTHMQA LAAQNQPLTS LIGQGYSGTI LPAVIQRNIL 100
    ENPAWYTAYT PYQPEISQGR LEALFNFQTM ICDLTGLDVA NASLLDEATA 150
    AAEAMALAER ASSVKTKAFF VDHEVHPQTL AVLRTRAEPL GWTLVTGDPL 200
    HDLDKADVFG AVLQYPGTSG VVRDLRPAIA AIKAKGGLAV VAADLLALTL 250
    LTSPGVLGAD IAIGSAQRFG VPMGYGGPHA AYMAVCNALK RLLPGRLVGL 300
    SVDSRGTPAY RLALQTREQH IRREKATSNI CTAQVLLAVI SSMYAVYHGP 350
    EGLAQIARTV HRHTATLAAG LTRLGFAPLN STAFDTLTVN AGERQSEIVK 400
    RASSQGINLR INADGTLGIA LDELTIEETV EALWRAFGAT WSYADVEAHA 450
    PDLLPADLKR KTAYLTHPVF HEHRSETELL RYMRKLSDRD LALDRAMIPL 500
    GSCTMKLNAT TEMIPLTWAA FANLHPFAPP EQAEGYFTLF ENFEEWLLDI 550
    TGYDAISLQP NSGAQGEYAG LLAIRGYHAA RGESHRTVCL IPSSAHGTNP 600
    ASANMAGMDV VVVACDARGD VDVDDLRTKS TQHADRLAAI MITYPSTHGV 650
    FEERIREICD IVHGHGGQVY LDGANMNAQV GLSRPGDYGA DVSHLNLHKT 700
    FCIPHGGGGP GMGPIGVKAH LAPFLPGHPA IDDATPSAVG PVSAAPFGSA 750
    SILTISYIYI LMMGSEGLKR ATEVAILNAN YIAQRLDPHF PVLYRNVKGR 800
    VAHECIIDPR ALKAKTGVTV DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT 850
    ESESKAELDR FCDAMIAIRQ EIAEIEAGRW KVEASPLRHA PHTAHDIADD 900
    AWSRPYSRAQ GCFPSGSSRS DKYWCPVGRV DNAYGDRNLV CSCPPVEDYA 950
    QAAE 954
    Length:954
    Mass (Da):102,794
    Last modified:October 11, 2005 - v1
    Checksum:i24D9EE73A28C9B9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000115 Genomic DNA. Translation: ABA04545.1.
    RefSeqiWP_011314571.1. NC_007406.1.
    YP_317897.1. NC_007406.1.

    Genome annotation databases

    EnsemblBacteriaiABA04545; ABA04545; Nwi_1284.
    GeneIDi3675080.
    KEGGinwi:Nwi_1284.
    PATRICi22699210. VBINitWin102302_1439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000115 Genomic DNA. Translation: ABA04545.1 .
    RefSeqi WP_011314571.1. NC_007406.1.
    YP_317897.1. NC_007406.1.

    3D structure databases

    ProteinModelPortali Q3ST46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323098.Nwi_1284.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA04545 ; ABA04545 ; Nwi_1284 .
    GeneIDi 3675080.
    KEGGi nwi:Nwi_1284.
    PATRICi 22699210. VBINitWin102302_1439.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci NWIN323098:GJEG-1307-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
      Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
      Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nb-255 / ATCC 25391.

    Entry informationi

    Entry nameiGCSP_NITWN
    AccessioniPrimary (citable) accession number: Q3ST46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3