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Q3ST46

- GCSP_NITWN

UniProt

Q3ST46 - GCSP_NITWN

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNWIN323098:GJEG-1307-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Nwi_1284
OrganismiNitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Taxonomic identifieri323098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000002531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000227109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei699 – 6991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi323098.Nwi_1284.

Structurei

3D structure databases

ProteinModelPortaliQ3ST46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ST46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIAREEPATT FARRHIGPSS RDIAAMLETV GAKSLEALMN EALPPSIRQK
60 70 80 90 100
TPLDLGEGFS ETEVLTHMQA LAAQNQPLTS LIGQGYSGTI LPAVIQRNIL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALFNFQTM ICDLTGLDVA NASLLDEATA
160 170 180 190 200
AAEAMALAER ASSVKTKAFF VDHEVHPQTL AVLRTRAEPL GWTLVTGDPL
210 220 230 240 250
HDLDKADVFG AVLQYPGTSG VVRDLRPAIA AIKAKGGLAV VAADLLALTL
260 270 280 290 300
LTSPGVLGAD IAIGSAQRFG VPMGYGGPHA AYMAVCNALK RLLPGRLVGL
310 320 330 340 350
SVDSRGTPAY RLALQTREQH IRREKATSNI CTAQVLLAVI SSMYAVYHGP
360 370 380 390 400
EGLAQIARTV HRHTATLAAG LTRLGFAPLN STAFDTLTVN AGERQSEIVK
410 420 430 440 450
RASSQGINLR INADGTLGIA LDELTIEETV EALWRAFGAT WSYADVEAHA
460 470 480 490 500
PDLLPADLKR KTAYLTHPVF HEHRSETELL RYMRKLSDRD LALDRAMIPL
510 520 530 540 550
GSCTMKLNAT TEMIPLTWAA FANLHPFAPP EQAEGYFTLF ENFEEWLLDI
560 570 580 590 600
TGYDAISLQP NSGAQGEYAG LLAIRGYHAA RGESHRTVCL IPSSAHGTNP
610 620 630 640 650
ASANMAGMDV VVVACDARGD VDVDDLRTKS TQHADRLAAI MITYPSTHGV
660 670 680 690 700
FEERIREICD IVHGHGGQVY LDGANMNAQV GLSRPGDYGA DVSHLNLHKT
710 720 730 740 750
FCIPHGGGGP GMGPIGVKAH LAPFLPGHPA IDDATPSAVG PVSAAPFGSA
760 770 780 790 800
SILTISYIYI LMMGSEGLKR ATEVAILNAN YIAQRLDPHF PVLYRNVKGR
810 820 830 840 850
VAHECIIDPR ALKAKTGVTV DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT
860 870 880 890 900
ESESKAELDR FCDAMIAIRQ EIAEIEAGRW KVEASPLRHA PHTAHDIADD
910 920 930 940 950
AWSRPYSRAQ GCFPSGSSRS DKYWCPVGRV DNAYGDRNLV CSCPPVEDYA

QAAE
Length:954
Mass (Da):102,794
Last modified:October 11, 2005 - v1
Checksum:i24D9EE73A28C9B9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000115 Genomic DNA. Translation: ABA04545.1.
RefSeqiYP_317897.1. NC_007406.1.

Genome annotation databases

EnsemblBacteriaiABA04545; ABA04545; Nwi_1284.
GeneIDi3675080.
KEGGinwi:Nwi_1284.
PATRICi22699210. VBINitWin102302_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000115 Genomic DNA. Translation: ABA04545.1 .
RefSeqi YP_317897.1. NC_007406.1.

3D structure databases

ProteinModelPortali Q3ST46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323098.Nwi_1284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA04545 ; ABA04545 ; Nwi_1284 .
GeneIDi 3675080.
KEGGi nwi:Nwi_1284.
PATRICi 22699210. VBINitWin102302_1439.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NWIN323098:GJEG-1307-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
    Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
    Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nb-255 / ATCC 25391.

Entry informationi

Entry nameiGCSP_NITWN
AccessioniPrimary (citable) accession number: Q3ST46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3