ID   Q3SRU0_NITWN            Unreviewed;       753 AA.
AC   Q3SRU0;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ABA05001.1};
GN   OrderedLocusNames=Nwi_1740 {ECO:0000313|EMBL:ABA05001.1};
OS   Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 /
OS   NCIMB 11846 / Nb-255).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Nitrobacteraceae; Nitrobacter.
OX   NCBI_TaxID=323098 {ECO:0000313|EMBL:ABA05001.1, ECO:0000313|Proteomes:UP000002531};
RN   [1] {ECO:0000313|EMBL:ABA05001.1, ECO:0000313|Proteomes:UP000002531}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255
RC   {ECO:0000313|Proteomes:UP000002531};
RX   PubMed=16517654; DOI=10.1128/AEM.72.3.2050-2063.2006;
RA   Starkenburg S.R., Chain P.S., Sayavedra-Soto L.A., Hauser L., Land M.L.,
RA   Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J.,
RA   Hickey W.J.;
RT   "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium
RT   Nitrobacter winogradskyi Nb-255.";
RL   Appl. Environ. Microbiol. 72:2050-2063(2006).
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DR   EMBL; CP000115; ABA05001.1; -; Genomic_DNA.
DR   RefSeq; WP_011314997.1; NC_007406.1.
DR   AlphaFoldDB; Q3SRU0; -.
DR   STRING; 323098.Nwi_1740; -.
DR   KEGG; nwi:Nwi_1740; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_5; -.
DR   OrthoDB; 9789782at2; -.
DR   Proteomes; UP000002531; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002531};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        386..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          504..642
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   753 AA;  81084 MW;  8C932D4CDB416346 CRC64;
     MKAATRLRNT LRVRAMLAWA RLRRLTRNKN LRAVGAAVVT LVLLASLRAY DPRIVTELKE
     RTFDTYQRLK PRAYTDLPVR IVDIDEASIS EYGQWPWPRT RLAALTRRLA DLGAGVVAYD
     VIFSEPDRTT PSRLANDLKD SGAPDLDQTL KLLANLPDHD QAFADAIENA GVVFGFAATG
     AVNDKRPPVR AGVAFVGVNP ANVLAPFGGT VSSLPILNQK AAGIGGINLS SHDRGGIVRR
     VPMLFSDGVS IYPSLAIEAL RVAQNQKSII VRGTGSSGDS DTGSAALIDM RVGAFKLPLT
     SNGESWVYFS RDRPQRYVSV KDILDPAKEA TVKPLVDGAI VLVGASAAGL MDSRTTPLGG
     SVPGVSVQAQ VIEQILAQDF IERPDWAKGL EIVLTLLFGA LVAGLVLMFG ARFSFYAGVV
     GFVAGLAGSW IAFSHFRLLI DPIFPSLAAL TVYIAVERVL HVASDREKKF VRQAFGQYLA
     PELLTQLENS PQEMRLGGAS RDISVMFMDV RGFTPISEAL TATELVDFIN TLLAPLSDAI
     QDELGTIDKY IGDSIMAFWN APADVPDHAT RACQAALKMR EALTALNDAD VFGFSARGFT
     DPRVRIGVGI NAGLACVGNM GSQRRFNYSA MGDVVNVAAR IESASKTLDV DLLVSEDVAR
     RVRGIALLEA GEILLKGKSR PTKIYAIVGD DSVAASPEFA EWKARHGALL AAIKAGEGFE
     ATAALARCRE LAGEDMQGFY HRLAEQIVPI HTM
//