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Q3SRI5

- LPXB_NITWN

UniProt

Q3SRI5 - LPXB_NITWN

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciNWIN323098:GJEG-1881-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Nwi_1846
OrganismiNitrobacter winogradskyi (strain Nb-255 / ATCC 25391)
Taxonomic identifieri323098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000002531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Lipid-A-disaccharide synthasePRO_0000255202Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323098.Nwi_1846.

Structurei

3D structure databases

ProteinModelPortaliQ3SRI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SRI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDEASANPS RKIFLIATEE SGDRLGSSLM KALRRRLGCS VRFEGVGGQT
60 70 80 90 100
MAREGLVSLF PIEELSIMGF TAVVKQLPMI VRRIRGTADA VIAAAPDVLV
110 120 130 140 150
IIDSPDFTHR VARRVRARCR GLPIVDYVSP SVWAWRSGRA RAMRSYVDHV
160 170 180 190 200
LALLPFEPEA YRRLGGPPCT YVGHPLLEQI GVLRPDAQER QRRDADPPTL
210 220 230 240 250
LVLPGSRRSE IRHHLSVFGE TIGMLQQSIP EIEVVLPTTP HLVDEITPAV
260 270 280 290 300
ATWPRRPRVV IGEDDKRAAF RVARAALAKS GTVTLELALA GVPMVAAYKA
310 320 330 340 350
GSVEAWIARR VIRVSSVILA NLVIRENVIP EFLQEDCVPG KLAPALQEIL
360 370 380 390
TDSPMRRRQL KAFDGLNTIM ATGQRSPSEL AADIVIEAMR ESRARM
Length:396
Mass (Da):43,640
Last modified:October 11, 2005 - v1
Checksum:iBBDE4D4CFCE7CAD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000115 Genomic DNA. Translation: ABA05106.1.
RefSeqiWP_011315102.1. NC_007406.1.
YP_318458.1. NC_007406.1.

Genome annotation databases

EnsemblBacteriaiABA05106; ABA05106; Nwi_1846.
GeneIDi3674817.
KEGGinwi:Nwi_1846.
PATRICi22700502. VBINitWin102302_2072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000115 Genomic DNA. Translation: ABA05106.1 .
RefSeqi WP_011315102.1. NC_007406.1.
YP_318458.1. NC_007406.1.

3D structure databases

ProteinModelPortali Q3SRI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323098.Nwi_1846.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA05106 ; ABA05106 ; Nwi_1846 .
GeneIDi 3674817.
KEGGi nwi:Nwi_1846.
PATRICi 22700502. VBINitWin102302_2072.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci NWIN323098:GJEG-1881-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
    Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
    Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nb-255 / ATCC 25391.

Entry informationi

Entry nameiLPXB_NITWN
AccessioniPrimary (citable) accession number: Q3SRI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3