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Q3SQC1 (Q3SQC1_NITWN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH1 HAMAP MF_00191
Ordered Locus Names:Nwi_2266
OrganismNitrobacter winogradskyi (strain Nb-255 / ATCC 25391) [Complete proteome] [HAMAP] EMBL ABA05520.1
Taxonomic identifier323098 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
Q3SQC1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 615A71BF3F0B226C

FASTA31433,649
        10         20         30         40         50         60 
MTDPRPIEVL LAQPRGFCAG VVRAIETVER ALEKYGPPVY VRHEIVHNKY VVESLKNKGA 

        70         80         90        100        110        120 
IFVEDLSEVP PKAVTVFSAH GVAQSVEEEA AARGLPVLNA TCPLVTKVHN QGKRYTSKGR 

       130        140        150        160        170        180 
TLILIGHAGH PEVEGTMGQV PGPVLLVQNV DDVAALTLPA DTPVAYITQT TLSVDDTKDI 

       190        200        210        220        230        240 
IIALQQRFTD IQGPDTRDIC YATQNRQSAV RDLSKLVDVI LVVGAANSSN SNRLREIGTE 

       250        260        270        280        290        300 
VGVASYLIAD GSELNAEWLE GAKAVGVTAG ASAPEVLVDD VIEALKRIRP VAVSVLPGRE 

       310 
ENIEFRLPSE LTSA

« Hide

References

[1]"Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed: 16517654] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000115 Genomic DNA. Translation: ABA05520.1.
RefSeqYP_318872.1. NC_007406.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ3SQC1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3675171.
GenomeReviewsGene locus Nwi_2266 in contig CP000115_GR.
KEGGnwi:Nwi_2266.
NMPDRfig|323098.3.peg.1242.
PATRIC22701470. VBINitWin102302_2547.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAHNQGKRY.
PhylomeDBQ3SQC1.
ProtClustDBPRK01045.

Enzyme and pathway databases

BioCycNWIN323098:NWI_2266-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ3SQC1_NITWN
AccessionPrimary (citable) accession number: Q3SQC1
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info