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Q3SPB7 (Q3SPB7_NITWN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333
Ordered Locus Names:Nwi_2621
OrganismNitrobacter winogradskyi (strain Nb-255 / ATCC 25391) [Complete proteome] [HAMAP] EMBL ABA05874.1
Taxonomic identifier323098 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region73 – 8210Important for dimerization By similarity HAMAP MF_00333
Region133 – 1353Substrate binding By similarity HAMAP MF_00333
Region265 – 30036Important for dimerization By similarity HAMAP MF_00333
Region283 – 2886Substrate binding By similarity HAMAP MF_00333

Sites

Active site1311Proton donor By similarity HAMAP MF_00333
Binding site1171Substrate By similarity HAMAP MF_00333
Site2001Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
Q3SPB7 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 40F83A5B2C281026

FASTA30033,871
        10         20         30         40         50         60 
MEATRLEDRT LEDRKARARS WFEQLRDDIC SAFEKLEDDA PASLYPGSAG RFVRTPWERT 

        70         80         90        100        110        120 
DHTGKPGGGG VMSMMHGRLF EKVGVHCSTV HGEFAPEFRA QIPGAADDPN FWASGISLIA 

       130        140        150        160        170        180 
HMRNPHIPAV HMNTRFVVTT KAWFGGGGDL TPVLMRRRTQ EDPDSVAFHA AMKAACDAHA 

       190        200        210        220        230        240 
AIAPYDKYKT WCDEYFHLPH RKEARGIGGI FYDWHDSGDW NADLAFTQDV GRALLKVYPE 

       250        260        270        280        290        300 
LVRRNFSTPW TAADREEQLI RRGRYAEFNL LYDRGTIFGL KTGGNVESIL SSMPPEVKWP

« Hide

References

[1]"Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255."
Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J.
Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed: 16517654] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000115 Genomic DNA. Translation: ABA05874.1.
RefSeqYP_319226.1. NC_007406.1.

3D structure databases

ProteinModelPortalQ3SPB7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3SPB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3674431.
GenomeReviewsGene locus Nwi_2621 in contig CP000115_GR.
KEGGnwi:Nwi_2621.
NMPDRfig|323098.3.peg.2583.
PATRIC22702278. VBINitWin102302_2947.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAVKAYLLD.
PhylomeDBQ3SPB7.
ProtClustDBPRK05330.

Enzyme and pathway databases

BioCycNWIN323098:NWI_2621-MONOMER.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ3SPB7_NITWN
AccessionPrimary (citable) accession number: Q3SPB7
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info