Q3SP50 (KHSE_NITWN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Nwi_2688

Organism

Nitrobacter winogradskyi (strain Nb-255 / ATCC 25391) [Complete proteome] [HAMAP]

Taxonomic identifier

323098 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_0000300796

Sequences

	Sequence		Length	Mass (Da)
	Q3SP50 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 07DF1E2435B0FE5E	FASTA	326	35,859
	10 20 30 40 50 60 MAVYTDVAAE ELADFLKAYD IGELLSYKGI AEGVENSNYL LHTTSGSFFL TLYEKRVAID 70 80 90 100 110 120 DLPFFLGLMG HLATHGIVCP QPVRTRNGET LGSLAGRPAA IIDFLEGVWP RKPNVAHCAA 130 140 150 160 170 180 VGAALAKLHL AGRDFSMRRA NALSVWSWRP LFEQAGACAD TVQPGLHDFL KAELDHLEAR 190 200 210 220 230 240 WPQELPGGVI HADLFPDNVL FLGDRLSGLI DFYFACHDFF AYDVAICLNA WCFEPDHAFN 250 260 270 280 290 300 VTKARALLGA YHRERALSEA EQAALPLLAR GAALRFLLTR LVDFLNVPAG ALVKPKDPLE 310 320 YVRKLRFQQR VGGVRDYGVA ILGPVA

References

[1]

"Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255." Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L., Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J., Arp D.J., Hickey W.J. Appl. Environ. Microbiol. 72:2050-2063(2006) [PubMed: 16517654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nb-255 / ATCC 25391.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000115 Genomic DNA. Translation: ABA05941.1.
RefSeq	YP_319293.1. NC_007406.1.
3D structure databases
ProteinModelPortal	Q3SP50.
SMR	Q3SP50. Positions 5-320.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SP50.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3675547.
GenomeReviews	Gene locus Nwi_2688 in contig CP000115_GR.
KEGG	nwi:Nwi_2688.
NMPDR	fig|323098.3.peg.2291.
PATRIC	22702432. VBINitWin102302_3024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	NWIN323098:NWI_2688-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_NITWN

Accession

Primary (citable) accession number: Q3SP50

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 11, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program