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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTDEN292415:G1G56-175-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Tbd_0173
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesThiobacillaceaeThiobacillus
Proteomesi
  • UP000008291 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000457101 – 483Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi292415.Tbd_0173

Structurei

3D structure databases

ProteinModelPortaliQ3SMC1
SMRiQ3SMC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG091H03O6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SMC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIFDHSRPG RTAAAQLPAT GGDLGDLPAE LRRKDAPALP EVSELDVVRH
60 70 80 90 100
YTRLSQKNFS IDTQFYPLGS CTMKYNPRAC NSLAMLPQFL ARHPASPDET
110 120 130 140 150
GQGFLASMFE LQEMLKDVTG MAGVSMAPMA GAHGEFAGVA MIRAYHDAKG
160 170 180 190 200
DAARREIIVP DAAHGTNPAT ATMCGYTVKE IPTDATGAVD LAALKAAVGP
210 220 230 240 250
QTAGLMLTNP STLGVFEKTI AEIQKIVHDA GGLLYYDGAN LNAILGKVRP
260 270 280 290 300
GDMGFDVIHM NLHKTFSTPH GGGGPGAGPV GVSGRLLPFM PIPLVLNDNG
310 320 330 340 350
FYRLATEADL PQSIGRMSAN MGNAGVLMRA YVYARLLGRE GMHRVAEYAT
360 370 380 390 400
LNANYLMAKL REAGFDLAYP TRRASHEFIV TLKKLKDATG VSAMDFAKRL
410 420 430 440 450
LDYGYHAPTT YFPLLVPECL LIEPTETESR ETLDGFVDAM KTIKHEAETN
460 470 480
PDLVKGAPYT LPVRRLDDVK AARELDLAYK PAA
Length:483
Mass (Da):52,035
Last modified:October 11, 2005 - v1
Checksum:i51A9184CFF18E37B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA Translation: AAZ96126.1
RefSeqiWP_011310686.1, NC_007404.1

Genome annotation databases

EnsemblBacteriaiAAZ96126; AAZ96126; Tbd_0173
KEGGitbd:Tbd_0173

Entry informationi

Entry nameiGCSPB_THIDA
AccessioniPrimary (citable) accession number: Q3SMC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health