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Q3SMB8

- GCSPA_THIDA

UniProt

Q3SMB8 - GCSPA_THIDA

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciTDEN292415:GHWG-179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Tbd_0176
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaHydrogenophilalesHydrogenophilaceaeThiobacillus
ProteomesiUP000008291: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045685Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi292415.Tbd_0176.

Structurei

3D structure databases

ProteinModelPortaliQ3SMB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SMB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFIPHTEED VSAMLGAIGA ASIEDLFDEI PPALKTGKLK DVPDGLPEMA
60 70 80 90 100
VARLMQERAS QDGFWSNFIG AGVYEHHIPA AIWQITTRGE FYSAYTPYQA
110 120 130 140 150
EASQGTLQLI YEYQTMMTRL TGLDVSNASL YDGASALAEA VLMAVRSHKS
160 170 180 190 200
SRRVLVPKTV HPVYRSVVVT TVRNQGIDLV ELEYDPATGK TVLPSEPGAF
210 220 230 240 250
AGLVIPQPNF FGVLEDVHTM TDWTHANGGL AIALVNPTTL AVLEAPGKWG
260 270 280 290 300
TKGADIAVGE GQPLGAPMAS GGPYFGFMCC RQDFVRQMPG RIVGRTVDLD
310 320 330 340 350
GKPGFALTLQ AREQHIRRSK ATSNICTNQG LVVTAATQYM ALLGPQGLAK
360 370 380 390 400
VAAASHANTV ALAEKLGAIP GVARAFASPC FHEVVLKLDD GTLKGTSAKD
410 420 430 440 450
VLRALRAQGI LGGLDISGWY PELGQAILVC VTETKTGADL DHYAQHLERI
460
LSKRREAPPC AYKN
Length:464
Mass (Da):49,680
Last modified:October 11, 2005 - v1
Checksum:iEEE4D40F3662AA9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000116 Genomic DNA. Translation: AAZ96129.1.
RefSeqiWP_011310689.1. NC_007404.1.
YP_313934.1. NC_007404.1.

Genome annotation databases

EnsemblBacteriaiAAZ96129; AAZ96129; Tbd_0176.
GeneIDi3673622.
KEGGitbd:Tbd_0176.
PATRICi23966495. VBIThiDen82923_0179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000116 Genomic DNA. Translation: AAZ96129.1 .
RefSeqi WP_011310689.1. NC_007404.1.
YP_313934.1. NC_007404.1.

3D structure databases

ProteinModelPortali Q3SMB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292415.Tbd_0176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ96129 ; AAZ96129 ; Tbd_0176 .
GeneIDi 3673622.
KEGGi tbd:Tbd_0176.
PATRICi 23966495. VBIThiDen82923_0179.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci TDEN292415:GHWG-179-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
    Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
    J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25259.

Entry informationi

Entry nameiGCSPA_THIDA
AccessioniPrimary (citable) accession number: Q3SMB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3