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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciTDEN292415:G1G56-178-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Tbd_0176
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesThiobacillaceaeThiobacillus
Proteomesi
  • UP000008291 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456851 – 464Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST464

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi292415.Tbd_0176

Structurei

3D structure databases

ProteinModelPortaliQ3SMB8
SMRiQ3SMB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SMB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIPHTEED VSAMLGAIGA ASIEDLFDEI PPALKTGKLK DVPDGLPEMA
60 70 80 90 100
VARLMQERAS QDGFWSNFIG AGVYEHHIPA AIWQITTRGE FYSAYTPYQA
110 120 130 140 150
EASQGTLQLI YEYQTMMTRL TGLDVSNASL YDGASALAEA VLMAVRSHKS
160 170 180 190 200
SRRVLVPKTV HPVYRSVVVT TVRNQGIDLV ELEYDPATGK TVLPSEPGAF
210 220 230 240 250
AGLVIPQPNF FGVLEDVHTM TDWTHANGGL AIALVNPTTL AVLEAPGKWG
260 270 280 290 300
TKGADIAVGE GQPLGAPMAS GGPYFGFMCC RQDFVRQMPG RIVGRTVDLD
310 320 330 340 350
GKPGFALTLQ AREQHIRRSK ATSNICTNQG LVVTAATQYM ALLGPQGLAK
360 370 380 390 400
VAAASHANTV ALAEKLGAIP GVARAFASPC FHEVVLKLDD GTLKGTSAKD
410 420 430 440 450
VLRALRAQGI LGGLDISGWY PELGQAILVC VTETKTGADL DHYAQHLERI
460
LSKRREAPPC AYKN
Length:464
Mass (Da):49,680
Last modified:October 11, 2005 - v1
Checksum:iEEE4D40F3662AA9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA Translation: AAZ96129.1
RefSeqiWP_011310689.1, NC_007404.1

Genome annotation databases

EnsemblBacteriaiAAZ96129; AAZ96129; Tbd_0176
KEGGitbd:Tbd_0176

Similar proteinsi

Entry informationi

Entry nameiGCSPA_THIDA
AccessioniPrimary (citable) accession number: Q3SMB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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