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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi486MagnesiumUniRule annotation1
Metal bindingi492MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Tbd_0693
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesThiobacillaceaeThiobacillus
Proteomesi
  • UP000008291 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003299181 – 706Polyribonucleotide nucleotidyltransferaseAdd BLAST706

Interactioni

Protein-protein interaction databases

STRINGi292415.Tbd_0693.

Structurei

3D structure databases

ProteinModelPortaliQ3SKX5.
SMRiQ3SKX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini552 – 611KHUniRule annotationAdd BLAST60
Domaini621 – 689S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SKX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIKKTFTY GRHQVTLETG EIARQASGAV VVNMDDTMVL VTVVAKNEVK
60 70 80 90 100
PGQDFFPLTV DYQEKTYAAG RIPGGFLKRE SRPSEGETLI SRLIDRPIRP
110 120 130 140 150
LFPEGFFNEV QIIATVMSSN PEVSADIPAL IGASAALSLS GLPFDGPVGA
160 170 180 190 200
ARVGFINGEY VLNPTNAELK DSALDLVVAG TESAVLMVES EAMELPEDIM
210 220 230 240 250
LGAVVFGHTQ MQAAINAINE LADEAGADAW DWAPPAEDTA MVDRLKALAE
260 270 280 290 300
DGLQQAYNIK QKRARMAAVD EVRSKAFAEL ITADMDTVAA NHVKDAFHRL
310 320 330 340 350
EAGVVRNRIL SGQPRIDGRD TRTVRPITIR TGVLPRAHGS ALFTRGETQA
360 370 380 390 400
LVVTTLGTGR DEQTIDALEG SYSDRFMLHY NMPPYATGET GRVGSPKRRE
410 420 430 440 450
IGHGRLAKRA LLAVLPSKEE FGYTMRVVSE ITESNGSSSM ASVCGGCLSL
460 470 480 490 500
MDAGAPLKAH VAGIAMGLIK EGNRFAVLTD ILGDEDHLGD MDFKVAGTEN
510 520 530 540 550
GVTALQMDIK ITGITKEIMQ AALTQAKEGR MHILGIMKAS VSETHEMSAY
560 570 580 590 600
APRIIAMKIN PEKIRDVIGK GGAVIRALTE ETGTQIDIQE DGSVKIACTS
610 620 630 640 650
MEAGELAKKR IEEITAEVEV GKVYEGPVIK LLDFGAIVNV LPGRDGLLHI
660 670 680 690 700
SQIAHERVNT IGDYLKEGQV VRVKILEADE KGRLRLSMKA LLEAPAPTSG

GEEHAS
Length:706
Mass (Da):75,876
Last modified:October 11, 2005 - v1
Checksum:iB70F3E74A4B956A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA. Translation: AAZ96646.1.
RefSeqiWP_011311205.1. NC_007404.1.

Genome annotation databases

EnsemblBacteriaiAAZ96646; AAZ96646; Tbd_0693.
KEGGitbd:Tbd_0693.

Similar proteinsi

Entry informationi

Entry nameiPNP_THIDA
AccessioniPrimary (citable) accession number: Q3SKX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families