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Protein

UvrABC system protein C

Gene

uvrC

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein C
Short name:
Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene namesi
Name:uvrC
Ordered Locus Names:Tbd_0701
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesThiobacillaceaeThiobacillus
Proteomesi
  • UP000008291 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002649711 – 598UvrABC system protein CAdd BLAST598

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.

Protein-protein interaction databases

STRINGi292415.Tbd_0701.

Structurei

3D structure databases

ProteinModelPortaliQ3SKW8.
SMRiQ3SKW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 91GIY-YIGAdd BLAST79
Domaini200 – 235UVRAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279961.
KOiK03703.
OMAiLFPIRQC.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiView protein in InterPro
IPR000305. GIY-YIG_endonuc.
IPR035901. GIY-YIG_endonuc_sf.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
PfamiView protein in Pfam
PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiView protein in PROSITE
PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SKW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDKEFLAS LPTLPGVYRM VDAAGAVLYV GKAKDLRKRV GSYFLKTDQS
60 70 80 90 100
PRIRLMLKSV DHIDTTVTRT EAEALLLENN LIKGLKPRFN ILFRDDKSYP
110 120 130 140 150
YLLLTGHGYP RLAYFRGAPK KRDQAFGPYP NSYAVRESIQ LLQKVFQLRT
160 170 180 190 200
CEDTVFGNRS RPCLLHQIKR CSAPCVSLVS AETYARDVAE AMLLLKGEAT
210 220 230 240 250
ALTEEITAQM NAAAENLDFE TAAYLRDRLR MLATVREKQF VDTTGSEADA
260 270 280 290 300
DVVAVAEVGG VIAVNLTMIR GGRHLGDRSF FPQHGEGAAL GEALEAFVAQ
310 320 330 340 350
HYLDHPIPAR ILVSEAIDSA ALQTLLSEQA GKKVTLQHRV TGERRVWIAM
360 370 380 390 400
AQANARLSAE RRSADRANQS QRLAALRDTL ELPTLNRIEC FDISHTMGEA
410 420 430 440 450
TIASCVVYEG DDLKKSDYRR YNIEGITPGD DYAAMHAALI KRFHRTVEEN
460 470 480 490 500
GVLPDLLLID GGKGQVAMAV EALAELGIDD VLLLGVAKGE SRKPGLETLI
510 520 530 540 550
FADGRELKLA RDHPGFHLIQ QVRDEAHRFA ITGHRAKRGK ARVQSTLEDI
560 570 580 590
AGIGPKRRKQ LLEHFGGLQG VRNAGVDALA SVNGISRELA EIIYNALH
Length:598
Mass (Da):65,968
Last modified:October 11, 2005 - v1
Checksum:iEA029C994C113025
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA. Translation: AAZ96654.1.

Genome annotation databases

EnsemblBacteriaiAAZ96654; AAZ96654; Tbd_0701.
KEGGitbd:Tbd_0701.

Similar proteinsi

Entry informationi

Entry nameiUVRC_THIDA
AccessioniPrimary (citable) accession number: Q3SKW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families