Q3SKP4 (Q3SKP4_THIDA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide deformylase 2 HAMAP MF_00163
Short name=PDF 2 HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163

Alternative name(s):
Polypeptide deformylase 2 HAMAP MF_00163

Gene names

Name:	def2 HAMAP MF_00163
Ordered Locus Names:	Tbd_0780

Organism

Thiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP] EMBL AAZ96733.1

Taxonomic identifier

292415 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163
Catalytic activity	Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163 SAAS SAAS000181
Cofactor	Binds 1 Fe2+ ion By similarity. HAMAP MF_00163
Sequence similarities	Belongs to the polypeptide deformylase family. HAMAP MF_00163

Ontologies

Keywords
Biological process	Protein biosynthesis HAMAP MF_00163 SAAS SAAS000181
Ligand	Iron HAMAP MF_00163 Metal-binding HAMAP MF_00163 SAAS SAAS000181
Molecular function	Hydrolase SAAS SAAS000181 HAMAP MF_00163 EMBL AAZ96733.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro peptide deformylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	143	1	By similarity HAMAP MF_00163
	Metal binding	100	1	Iron By similarity HAMAP MF_00163
	Metal binding	142	1	Iron By similarity HAMAP MF_00163
	Metal binding	146	1	Iron By similarity HAMAP MF_00163

Sequences

	Sequence		Length	Mass (Da)
	Q3SKP4 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: E1B5FEB78BC93011	FASTA	177	19,344
	10 20 30 40 50 60 MAVREVLKMG DPRLLAPARA VERFATAELA QLVADMHDTM RALNGAGLAA PQIGVSLQVV 70 80 90 100 110 120 IFEVNANPRY PDAAEVPLTV LVNPVVTPLS DATEEGWEGC LSVPGMRGLV PRHGEIHYRG 130 140 150 160 170 FDAAGRALER RVSGFHARVV QHEVDHLNGI LYPMRIPDLR NFGFTDTLFP GQTLQDD

References

[1]

"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans." Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P. J. Bacteriol. 188:1473-1488(2006) [PubMed: 16452431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000116 Genomic DNA. Translation: AAZ96733.1.
RefSeq	YP_314538.1. NC_007404.1.
3D structure databases
ProteinModelPortal	Q3SKP4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SKP4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3673974.
GenomeReviews	Gene locus Tbd_0780 in contig CP000116_GR.
KEGG	tbd:Tbd_0780.
NMPDR	fig|292415.3.peg.44.
PATRIC	23967729. VBIThiDen82923_0779.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0242.
HOGENOM	HBG665227.
OMA	HNERYPD.
ProtClustDB	PRK00150.
Enzyme and pathway databases
BioCyc	TDEN292415:TBD_0780-MONOMER.
Family and domain databases
HAMAP	MF_00163. Pep_deformylase. [Tree]
InterPro	IPR000181. Fmet_deformylase. IPR023635. Peptide_deformylase. [Graphical view]
Gene3D	G3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KO	K01462.
PANTHER	PTHR10458. Fmet_deformylase. 1 hit.
Pfam	PF01327. Pep_deformylase. 1 hit. [Graphical view]
PIRSF	PIRSF004749. Pep_def. 1 hit.
PRINTS	PR01576. PDEFORMYLASE.
SUPFAM	SSF56420. Fmet_deformylase. 1 hit.
TIGRFAMs	TIGR00079. Pept_deformyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q3SKP4_THIDA

Accession

Primary (citable) accession number: Q3SKP4

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)