Reviewed, UniProtKB/Swiss-Prot Q3SK85 (HIS81_THIDA)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	Tbd_0952

Organism

Thiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]

Taxonomic identifier

292415 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153471
Amino acid modifications
	Modified residue	233	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SK85-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: A3457C4415E77AA1	FASTA	384	40,437
	10 20 30 40 50 60 MSGCDSICAA TAPPHVRAIA PYQPGKPISE LARELGLAEA DIVKLASNEN PLGPSPFALA 70 80 90 100 110 120 AAQDALLDMA LYPDGAGYAL KAKLSARLGV DAAQIVLGNG SNDVLDMVAR AYLAPGTSAV 130 140 150 160 170 180 YAQYAFAVYP IATHTVGAHG IAVAARDFGH DLERMRAAIR DDTRVVWIAN PNNPTGTFLP 190 200 210 220 230 240 WNEIEAFLET VPPRVLVVLD EAYGEYLAPA SRCDTAAWVV RFPNLLISRT FSKAYGLAGL 250 260 270 280 290 300 RVGYGIGHAD VVDLLNRVRH PFNVNASALA AAEAALDDDA FLARSYALNA AGMQQLLGGL 310 320 330 340 350 360 AALDIETVPS KGNFVLARVG DAARINTELL KRGVIVRPVA AYGLPEFLRV SVGLAGQNAR 370 380 FLDALGEVLA AAPGRHPDSR KALP

References

[1]

"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans." Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P. J. Bacteriol. 188:1473-1488(2006) [PubMed: 16452431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000116 Genomic DNA. Translation: AAZ96905.1.
RefSeq	YP_314710.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3672744.
GenomeReviews	Gene locus Tbd_0952 in contig CP000116_GR.
KEGG	tbd:Tbd_0952.
NMPDR	fig|292415.3.peg.542.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3SK85.
OMA	Q3SK85. KGYIVRS.
Enzyme and pathway databases
BioCyc	TDEN292415:TBD_0952-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_THIDA

Accession

Primary (citable) accession number: Q3SK85

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)