Reviewed, UniProtKB/Swiss-Prot Q3SI68 (HIS82_THIDA)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	Tbd_1712

Organism

Thiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]

Taxonomic identifier

292415 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000153472
Amino acid modifications
	Modified residue	215	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SI68-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 2B183CEAFDE2C561	FASTA	357	38,963
	10 20 30 40 50 60 MSRTSTSRYW SAVVGALTPY VPGEQPKLAN LVKLNTNENP YGPSPRVLEA LRGEVGDTLR 70 80 90 100 110 120 LYPDPNSDRL RAAIAAYHAV SPDQVFVGNG SDEVLAHTFL ALLKHERPVF FPDITYSFYP 130 140 150 160 170 180 VYCGLYGIAH RAIPLDDAFE IRVDDYLAPK GGVIFPNPNA PTGRLLALGE IERLLAANRD 190 200 210 220 230 240 SVVVIDEAYV DFGGDSAVPL VARHPQLLVT RTLSKSHALA GLRVGYAVGQ APLIEALNRV 250 260 270 280 290 300 KDSFNSYPLD RFAQAGALAS IEDRAYFESI CARVIATRTR LVDAMESLGF EVLPSAANFI 310 320 330 340 350 FARHPAHDGE ALAARLRERS IIVRHFKNPA RIAPFLRITV GTDAQCDALV DALKALC

References

[1]

"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans." Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P. J. Bacteriol. 188:1473-1488(2006) [PubMed: 16452431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000116 Genomic DNA. Translation: AAZ97665.1.
RefSeq	YP_315470.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SI68.
Genome annotation databases
GeneID	3671295.
GenomeReviews	Gene locus Tbd_1712 in contig CP000116_GR.
KEGG	tbd:Tbd_1712.
NMPDR	fig|292415.3.peg.1809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3SI68.
OMA	DEQFQIR.
Enzyme and pathway databases
BioCyc	TDEN292415:TBD_1712-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_THIDA

Accession

Primary (citable) accession number: Q3SI68

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	October 11, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)